Zobrazeno 1 - 3
of 3
pro vyhledávání: '"William CK Pomerantz"'
Autor:
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, Silvia Toledo Ramos, David D Thomas, William CK Pomerantz, Tanya S Freedman, Nicholas M Levinson
Publikováno v:
eLife, Vol 13 (2024)
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why activation rather than inhibition occurs remains unclear. Using
Externí odkaz:
https://doaj.org/article/908aea3f4eb7430b8ef82e94417a536d
Autor:
Mladen Koravovic, Anand Mayasundari, Gordana Tasic, Fatemeh Keramatnia, Timothy R. Stachowski, Huarui Cui, Sergio C. Chai, Barbara Jonchere, Lei Yang, Yong Li, Xiang Fu, Ryan Hiltenbrand, Leena Paul, Vibhor Mishra, Jeffery M. Klco, Martine F. Roussel, William CK. Pomerantz, Marcus Fischer, Zoran Rankovic, Vladimir Savic
Publikováno v:
European Journal of Medicinal Chemistry
An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic amides. This effort led to the discovery of potent BET inhibitors displaying overall improved profiles when compared to JQ1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5648b26b4c7d2361e3341b7c58a3cd9
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4513
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4513
Autor:
Rasmussen, Damien M., Semonis, Manny M., Greene, Joseph T., Muretta, Joseph M., Thompson, Andrew R., Ramos, Silvia Toledo, Thomas, David D., Pomerantz, William C. K., Freedman, Tanya S., Levinson, Nicholas M.
Publikováno v:
eLife; 5/14/2024, p1-22, 22p