Zobrazeno 1 - 10
of 11
pro vyhledávání: '"William C. Zinkand"'
Autor:
Andre I. Salama, William C. Zinkand, Jitendra Patel, P.A. DeFeo, Carolann Thompson, Helen Hargrove
Publikováno v:
European Journal of Pharmacology. 212:129-136
Quisqualate is a potent neurotoxin in cortical cultures of the rat. Unlike N-methyl-D-aspartate (NMDA), the toxicity of quisqualate is due to overstimulation of a membrane receptor after the agonist has been removed. This receptor appears to be the 2
Publikováno v:
Molecular and Chemical Neuropathology. 16:1-10
Ibotenic acid (Ibo) has been shown to have agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites in several systems. Both of these receptor sites have been implicated in excitotoxici
Autor:
Andre I. Salama, D. LaMonte, Thomas J. Mangano, Jitendra Patel, P. J. Warwick, William C. Zinkand, R. J. Powel, Richard A. Keith, M. Britt, Linda M. Pullan, Robert J. Stumpo, M. J. Chapdelaine
Publikováno v:
Journal of Neurochemistry. 55:1346-1351
HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enan
Publikováno v:
NeuroReport. 5:148-150
In primary cultures of rat cerebral cortex, N-methyl-D-aspartate causes widespread neurotoxicity. Inhibitors of the nitric oxide generating the enzyme nitric oxide synthase has been shown to attenuate the effects of N-methyl-D-aspartate in a number o
Autor:
Jitendra Patel, William C. Zinkand
Publikováno v:
The Metabotropic Glutamate Receptors ISBN: 9781617370069
Glutamate is believed to be the key mediator in neurodegenerative processes associated with stroke, epilepsy, and a broad spectrum of neurodegenerative disorders, including, Huntington’ s disease and Alzheimer disease (Choi, 1988; Beal, 1993). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ac53b03fcd459fd1f8653ca28302a1
https://doi.org/10.1007/978-1-4757-2298-7_9
https://doi.org/10.1007/978-1-4757-2298-7_9
Publikováno v:
Annals of the New York Academy of Sciences. 648
Autor:
William C. Zinkand, Andre I. Salama, Thomas J. Mangano, Richard A. Keith, Jitendra Patel, Andrea B. Klika
Publikováno v:
Journal of neurochemistry. 55(1)
Based on radioligand binding and electrophysiological studies, quinoxalinediones such as 6,7-dinitroquinoxaline-2,3-dione (DNQX) have been shown to be potent competitive antagonists at the quisqualate and kainate subtypes of the glutamate receptor. I
Publikováno v:
Journal of neurochemistry. 54(3)
Current evidence indicates that glutamate acting via the N-methyl-d-aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a variety of neurological disorders. In this report the role of glycine
Publikováno v:
Biophysical Journal. 51:388a-439a
Publikováno v:
Journal of General Physiology. 92:431-447
The voltage-dependent gating of single, batrachotoxin-activated Na channels from rat brain was studied in planar lipid bilayers composed of negatively charged or neutral phospholipids. The relationship between the probability of finding the Na channe