Zobrazeno 1 - 5
of 5
pro vyhledávání: '"William C. T. Unrath"'
Autor:
Arnold L. Smith, Allan Weber, Kevin L. Nelson, William C. T. Unrath, William N. Howald, Toni Kline, Alice L. Erwin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2820-2829
The p -nitroaromatic antibiotic chloramphenicol has been used extensively to treat life-threatening infections due to Haemophilus influenzae and Neisseria meningitidis ; its mechanism of action is the inhibition of protein synthesis. We found that du
Autor:
Arnold L. Smith, Alice L. Erwin, Kevin L. Nelson, Leonard W. Mayer, Claudio Tavares Sacchi, Sara A. Sandstedt, Cynthia R. Pleatman, Mary Jordan Theodore, William C. T. Unrath, Janet R. Gilsdorf, Paul J. Bonthuis, Jennifer L. Geelhood, Elizabeth A. Mothershed, Mathew Diggle
Publikováno v:
Journal of bacteriology. 190(4)
The gram-negative bacterium Haemophilus influenzae is a human-restricted commensal of the nasopharynx that can also be associated with disease. The majority of H. influenzae respiratory isolates lack the genes for capsule production and are nontypeab
Autor:
Derrick W. Crook, Jennifer L. Geelhood, Monica M. Farley, Richard F. Jacobs, Arnold L. Smith, Kevin L. Nelson, William C. T. Unrath, José Campos, Paul J. Bonthuis, Gregory Morlin, Miriam Golomb, Sarah W. Satola, Frederick W. Henderson, Kathrin Mühlemann, Alice L. Erwin, Loek van Alphen, Tendai Mhlanga-Mutangadura
Publikováno v:
Infection and immunity. 73(9)
The ability of unencapsulated (nontypeable) Haemophilus influenzae (NTHi) to cause systemic disease in healthy children has been recognized only in the past decade. To determine the extent of similarity among invasive nontypeable isolates, we compare
Autor:
William C. T. Unrath, Marcella R. Bothwell, Jason L. Furrer, Dayle A. Daines, Natalie Melrose, Arnold L. Smith, Michael A. Apicella, Justin Jarisch, Kevin L. Nelson, Laura L Greiner
Publikováno v:
Microbial pathogenesis. 39(3)
To gain insight into the role of luxSHi in disease pathogenesis, we inactivated that gene in several non-typeable Haemophilus influenzae isolates with an antibiotic resistance cassette. Gene inactivation was confirmed by PCR and by Southern blot anal
Autor:
Derek K. Ho, Alice L. Erwin, Arnold L. Smith, Simon Allen, Paul J. Bonthius, William C. T. Unrath, Michael E. Watson, Michael A. Apicella, Kevin L. Nelson, Justin Jarisch, David L. Tsao, Bradford W. Gibson
Publikováno v:
Infection and Immunity. 74:7047-7047
We are investigating a nontypeable Haemophilus influenzae (NTHI) strain, R2866, isolated from a child with meningitis. R2866 is unusually resistant to killing by normal human serum. The serum 50% inhibitory concentration (IC 50 ) for this strain is 1