Zobrazeno 1 - 10
of 11
pro vyhledávání: '"William C. Randall"'
Publikováno v:
Metabolism. 44:1527-1531
Production of unusual phosphorylated metabolites in the lens is one of several changes caused by hyperglycemia. Sorbitol 3-phosphate (Sor-3P) and fructose 3-phosphate (Fru-3P) are two such compounds identified in the diabetic lens, and galactitol 2-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1442fd057b7ca9425314327b051074
https://doi.org/10.1016/0026-0495(95)90069-1
https://doi.org/10.1016/0026-0495(95)90069-1
Autor:
Richard S. Alexander, William C. Randall, Graham M. Smith, James P. Springer, Brian M. McKeever, David W. Christianson, Charles N. Habecker, John J. Baldwin, Gerald S. Ponticello
Publikováno v:
Protein Science. 3:118-125
The 3-dimensional structure of human carbonic anhydrase II (HCAII; EC 4.2.1.1) complexed with 3 structurally related inhibitors, 1a, 1b, and 1c, has been determined by X-ray crystallographic methods. The 3 inhibitors (1a = C8H12N2O4S3) vary only in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::111801c085a16909f1a3035d0a460b1f
https://doi.org/10.1002/pro.5560030115
https://doi.org/10.1002/pro.5560030115
Autor:
Francis Kappler, Alan Siegel, Rosalind Stevens, Benjamin S. Szwergold, Truman R. Brown, Scott K. Howell, Sundeep Lal, William C. Randall, Paul J. Beisswenger
Summary To address the role of 3-deoxyglucosone (3DG) and the activity of its major degradative pathways in diabetic nephropathy and retinopathy we have measured 3DG and its degradation products [3-deoxyfructose (3DF) and 3-deoxy-2-keto-gluconic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae951b6f8e0042f016599d8bd4bcfb0f
https://doi.org/10.1533/9781845698447.7.298
https://doi.org/10.1533/9781845698447.7.298
Autor:
Francis Kappler, Bangying Su, Sundeep Lal, William C Randall, Michael A Walker, Anne Taylor, Benjamin S Szwergold, Truman R Brown, Shirin Djafroudi, Holger Kayser, Helmut Erbersdobler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b7e051c65d77f74bfeeb22fa85f67a3
https://doi.org/10.1533/9781845698447.8.415a
https://doi.org/10.1533/9781845698447.8.415a
Autor:
Truman R. Brown, Francis Kappler, Sundeep Lal, Paul J. Beisswenger, William C. Randall, Benjamin S. Szwergold, Michael Walker
3-deoxyglucosone (3DG), a reactive dicarbonyl sugar involved in nonenzymatic glycation of proteins is found in elevated concentrations in diabetic patients and has been implicated in the pathogenesis of diabetic complications. In this study, we provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b91d9391efbecb1f44975f9d046593cc
https://doi.org/10.1533/9781845698447.7.291
https://doi.org/10.1533/9781845698447.7.291
Autor:
Anne Taylor, William C. Randall, Benjamin S. Szwergold, Truman R. Brown, Francis Kappler, Sundeep Lal, Michael Walker
Publikováno v:
Metabolism: clinical and experimental. 46(11)
Previous studies have suggested that polyol-pathway and nonenzymatic glycation may be involved in the development of cardiac myopathy, a well-known manifestation of diabetes. Although the exact etiology of this complication is not fully understood, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d527df02ffebe2781b30abea88236df7
https://pubmed.ncbi.nlm.nih.gov/9361695
https://pubmed.ncbi.nlm.nih.gov/9361695
Autor:
Francis Kappler, Anne Taylor, Truman R. Brown, Benjamin S. Szwergold, Kevin J. Wells-Knecht, John W. Baynes, William C. Randall, Sundeep Lal
Publikováno v:
Archives of biochemistry and biophysics. 318(1)
Fructose-S-phosphate and sorbitol-3-phosphate are produced in diabetic rat lenses by a 3-phosphokinase. While sorbitol-3-phosphate appears to be an inert polyol phosphate, fructose-3-phosphate is a potent cross-linking agent and a potential in vivo s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b856d30a59662f7ecd208ff95f3963
https://pubmed.ncbi.nlm.nih.gov/7726561
https://pubmed.ncbi.nlm.nih.gov/7726561
Autor:
Steven M. Pitzenberger, Robert J. Gould, Patricia K. Lumma, Daniel F. Veber, Victor M. Garsky, Roger M. Freidinger, William C. Randall, Paul A. Friedman
Publikováno v:
Proceedings of the National Academy of Sciences. 86:4022-4026
Echistatin, a polypeptide from the venom of the saw-scaled viper, Echis carinatus, containing 49 amino acids and 4 cystine bridges was synthesized by solid-phase methodology in 4% yield. In the final step, air oxidation of the octahydroderivative was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800b76a6fdcac739c829e0d749ae43d4
https://doi.org/10.1073/pnas.86.11.4022
https://doi.org/10.1073/pnas.86.11.4022
Autor:
Thomas F. Lyon, William C. Randall
Publikováno v:
Life sciences. 26(14)
Under the conditions employed in a standard displacement assay of [3H]WB-4101 from calf neocortical membrane homogenates (0.22 nM total [3H]WB-4101), 70–80% of this radioligand is bound to a high affinity receptor site and 20–30% to a second, low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63256c7ca27eac134fc9894b279b5bf9
https://pubmed.ncbi.nlm.nih.gov/6104761
https://pubmed.ncbi.nlm.nih.gov/6104761
Autor:
Richard Saperstein, Roger M. Freidinger, D. F. Veber, Byron H. Arison, William C. Randall, D. S. Perlow
Publikováno v:
International journal of peptide and protein research. 23(2)
A model for the bioactive conformation of the highly active cyclic hexapeptide somatostatin analog cyclo-(Pro-Phe-d-Trp-Lys-Thr-Phe) has been proposed. As a test of this model, several compounds containing lactam and N-Me amino acid conformational mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbd0e44bb38c3c63c50aa948333382f
https://pubmed.ncbi.nlm.nih.gov/6142021
https://pubmed.ncbi.nlm.nih.gov/6142021