Výsledky vyhledávání - "William C. Powell"

Metallographic in situ hybridization

Autor: James Pettay, Richard D. Powell, William C. Powell, Raymond R. Tubbs, Patrick C. Roche, James F. Hainfeld, Thomas M. Grogan

Publikováno v: Human Pathology. 38:1145-1159

Metallographic methods, in which a target is visualized using a probe or antibody that deposits metal selectively at its binding site, offers many advantages for bright-field in situ hybridization (ISH) detection as well as for other labeling and det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b2f55c47128ec77542afe650e067c1
https://doi.org/10.1016/j.humpath.2007.05.004

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A New Rabbit Monoclonal Antibody (4B5) for the Immunohistochemical (IHC) Determination of the HER2 Status in Breast Cancer: Comparison With CB11, Fluorescence In Situ Hybridization (FISH), and Interlaboratory Reproducibility

Autor: David J. Dabbs, Katherine M. Scott, Shannon Tarr, Thomas M. Grogan, Raymond R. Tubbs, Richard W. Brown, David G. Hicks, Raymond B. Nagle, William C. Powell, Patrick C. Roche, Tristin Williams, Sarah M. Short, Simas Laniauskas, Nichole Prescott, James Pettay

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 15:94-102

The 2 methodologies in current clinical use to assess HER2 status in breast cancer are: fluorescence in situ hybridization (FISH) (gene amplification) and immunohistochemistry (protein over-expression). A consistent finding has been that 3% to 15% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20c4818ea8e419b3fabbaf36812eefa5
https://doi.org/10.1097/pai.0b013e31802ced25

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A Rat Monoclonal Antibody That Recognizes Pro- And Active MMP-7 Indicates Polarized Expression In Vivo

Autor: William C. Powell, John R. Couchman, Howard C. Crawford, Barbara Fingleton, Lynn M. Matrisian

Publikováno v: Hybridoma. 26:22-27

Matrix metalloproteinases (MMPs) are a family of enzymes named for their ability to degrade proteins of the extracellular matrix. Here we describe the characterization of a rat monoclonal antibody specifically recognizing one member of this enzyme fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9670aae72effb90398162a101ee916af
https://doi.org/10.1089/hyb.2006.028

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Suppression of Prostate Carcinoma Cell Invasion by Expression of Antisense L-Plastin Gene

Autor: Nandini Rudra-Ganguly, Jianping Zheng, William C. Powell, Pradip Roy-Burman

Publikováno v: The American Journal of Pathology. 155:115-122

Based on the finding that gene expression for the actin-bundling protein L-plastin is inducible by androgen and that L-plastin is overexpressed in malignant epithelium of the prostate, we examined the functional consequences of L-plastin down-regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780964b06f45c7f1dcdb23c5b337995e
https://doi.org/10.1016/s0002-9440(10)65106-1

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Matrilysin Expression in the Involuting Rat Ventral Prostate

Autor: Raymond B. Nagle, Joan M. Mitchen, Lynn M. Matrisian, William C. Powell, Frederick E. Domann, G. Tim Bowden

Publikováno v: The Prostate. 29:159-168

Matrilysin (PUMP-1) is a member of the matrix metalloproteinase (MMP) family of extracellular matrix degrading enzymes that has been found to be overexpressed in human prostate cancer. The rat ventral prostate (RVP) following castration has been used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcc4bceb5d720235ed70a1244b43c394
https://doi.org/10.1002/1097-0045(199609)29:3<159::aid-pros2990290304>3.0.co

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Automation of manual components and image quantification of direct dual label fluorescence in situ hybridization (FISH) for HER2 gene amplification: A feasibility study

Autor: Eric Swain, James Pettay, Thomas M. Grogan, David G. Hicks, Raymond R. Tubbs, William C. Powell, Patrick C. Roche

Publikováno v: Applied immunohistochemistrymolecular morphology : AIMM. 14(4)

Determination of HER2 status by fluorescence in situ hybridization (FISH) in breast carcinoma correlates well with response to targeted therapy and prognosis. However, manual time consuming methods and quantification aspects of the procedure may be c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f6ac8526021c16b14924417ff75bed
https://pubmed.ncbi.nlm.nih.gov/17122642

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High-resolution immunophenotyping of subcellular compartments in tissue microarrays by enzyme metallography

Autor: James F. Hainfeld, William C. Powell, Patrick C. Roche, James Pettay, Thomas M. Grogan, David G. Hicks, Raymond R. Tubbs, Richard D. Powell

Publikováno v: Applied immunohistochemistrymolecular morphology : AIMM. 13(4)

Ultrasensitive bright field in situ hybridization assays using enzyme metallography (EnzMet) have been developed and validated, but little is known regarding the applicability of EnzMet for immunophenotypic detection of protein via IHC. Superior reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d096e2eb5278bf8f1f4b579d2944f3c4
https://pubmed.ncbi.nlm.nih.gov/16280669

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Genetically defined mouse models that mimic natural aspects of human prostate cancer development

Autor: Pradip Roy-Burman, Michael B. Cohen, William C. Powell, J Hagenkord, Hong Wu

Publikováno v: Endocrine-related cancer. 11(2)

This review is focused on mouse models for prostate cancer that have been designed on the basis of genetic alterations that are frequently found in human prostate cancer. It begins with an analysis of the similarities and differences in the gross and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845835aee9b3d31f4c25e9773ad8a247
https://pubmed.ncbi.nlm.nih.gov/15163300

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Mouse strains for prostate tumorigenesis based on genes altered in human prostate cancer

Autor: Pradip Roy-Burman, Michael B. Cohen, William C. Powell, G. J. Miller, Robert D. Cardiff

Publikováno v: Current drug targets. 4(3)

Animal models of prostate cancer have been limited in number and in relevance to the human disease. With the advancement of transgenic and knockout technologies, combined with tissue specific promoters and tissue-specific gene ablation, a new generat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20ace0269247f27082b66f83dd53d0a
https://pubmed.ncbi.nlm.nih.gov/12643476

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