Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William C. Kieper"'
Autor:
John P. Vasilakos, Jacqueline Bjornton-Severson, Mark A. Tomai, John A. Hanten, Christie L Riter, Emily Waller, William C. Kieper, Sefik S. Alkan, Kevin S. Gorski, Jeffrey S. Miller, Keith B. Gorden
Publikováno v:
International Immunology. 18:1115-1126
NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -
Autor:
Esteban Celis, Richard B. Kennedy, Anita H. Undale, Larry R. Pease, Matthew S. Block, William C. Kieper
Publikováno v:
The Journal of Immunology. 174:3967-3977
Under optimal Ag stimulation, CTL become functional effector and memory T cells. Professional APCs (pAPC) are considered essential for the activation of CTL, due to their unique capacity to provide costimulation and present exogenous Ags through MHC
Autor:
Joon Youb Lee, Wolfgang Dummer, Charles D. Surh, William C. Kieper, Hao Shen, John J. Cebra, Chris Ramsey, J. Theodore Burghardt, Han-Qing Jiang, Amy E. Troy
Publikováno v:
The Journal of Immunology. 174:3158-3163
Homeostatic proliferation of naive T cells transferred to T cell-deficient syngeneic mice is driven by low-affinity self-MHC/peptide ligands and the cytokine IL-7. In addition to homeostatic proliferation, a subset of naive T cells undergoes massive
Autor:
Joyce T. Tan, Stephane Sidobre, Laurent Gapin, Jennifer L. Matsuda, Charles D. Surh, William C. Kieper, Mitchell Kronenberg, Rhodri Ceredig
Publikováno v:
Nature Immunology. 3:966-974
CD1d-reactive natural killer T (NKT) cells with an invariant V alpha 14 rearrangement (V alpha 14i) are a distinct subset of T lymphocytes that likely have important immune-regulatory functions. Little is known regarding the factors responsible for t
Autor:
Kristin A. Hogquist, Thomas A. Neubert, Yun Lu, William C. Kieper, Kenneth L. Johnson, Stephen C. Jameson, Stephen Naylor, Fabio R. Santori, Stanislav Vukmanovic, Stuart M. Brown
Publikováno v:
Immunity. 17(2):131-142
Although it is clear that positive selection of T cells involves recognition of specific self-peptide/MHC complexes, the nature of these self-ligands and their relationship to the cognate antigen are controversial. Here we used two complementary stra
Publikováno v:
The Journal of Experimental Medicine
The overall size and composition of the pool of naive and memory T cells are tightly regulated by homeostatic mechanisms. Recent work has shown that homeostasis of naive T cells is controlled by two factors, self-major histocompatibility complex (MHC
Autor:
Laurent Gapin, Joyce T. Tan, Brea Bondi-Boyd, Jonathan Sprent, Charles D. Surh, William C. Kieper, Rhodri Ceredig
Publikováno v:
The Journal of Experimental Medicine
Transgenic (TG) mice expressing a high copy number of interleukin (IL)-7 cDNA under the control of the major histocomaptability complex (MHC) class II promoter display a 10–20-fold increase in total T cell numbers. Here, we show that the increase i
Publikováno v:
The Journal of Immunology. 166:5515-5521
The size of the T lymphocyte pool is maintained by regulation of T cell production, proliferation, and survival. Under the pressure of a T lymphopenic environment, mature naive T cells begin to proliferate in the absence of Ag, a process called homeo
Publikováno v:
Nature Immunology. 1:426-432
The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cel
Autor:
Kristin A. Hogquist, Stephen Naylor, William C. Kieper, Maureen A. McGargill, Andy J. Tomlinson, Marilyn C. Hart, Stephen C. Jameson
Publikováno v:
Immunity. 6:389-399
In the thymus, positive and negative selection shape the T cell repertoire. It has previously been shown that positive selection, like negative selection, is the result of the interaction of the TCR with self-peptides bound to MHC. However, little is