Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William C. Kershaw"'
Publikováno v:
Journal of Toxicology and Environmental Health. 35:51-62
The purpose of this study was to determine if Zn pretreatment could protect rat primary hepatocyte cultures from the cytotoxicity of five metals that have little or no affinity for metallothionein (MT). Hepatocytes were grown in monolayer cultures fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abba8a8cfaa078e7c0f2da13b8408f22
https://doi.org/10.1080/15287399209531593
https://doi.org/10.1080/15287399209531593
Publikováno v:
Toxicology and Applied Pharmacology. 107:27-34
Metallothionein (MT), a low-molecular-weight, cysteine-rich, metal-binding protein, has been implicated in the detoxification of Cd. However, whether MT protects against the cellular toxicity of other metals has not been examined thoroughly. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0eb23316928111edfffe29e074054d4
https://doi.org/10.1016/0041-008x(91)90327-b
https://doi.org/10.1016/0041-008x(91)90327-b
Ethanol decreases cadmium hepatotoxicity in rats: Possible role of hepatic metallothionein induction
Publikováno v:
Toxicology and Applied Pharmacology. 106:448-455
The present investigation examines the possibility that Cd and ethanol have a significant toxicological interaction. This examination was warranted as exposure to either chemical is known to compromise human health. Inasmuch as both chemicals affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7d83ed55432085c29f3c025a3d4ff4
https://doi.org/10.1016/0041-008x(90)90339-v
https://doi.org/10.1016/0041-008x(90)90339-v
Publikováno v:
Toxicology and Applied Pharmacology. 104:267-275
The purpose of this study was to quantitate hepatic metallothionein-I (MT-I) and metallothionein-II (MT-II) in adult mice pretreated with various dosages of selected inorganic and organic compounds and in nonchemically treated neonatal mice. Male CF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78aea8b094a2faa2dd580240621a51de
https://doi.org/10.1016/0041-008x(90)90301-a
https://doi.org/10.1016/0041-008x(90)90301-a
Autor:
Curtis D. Klaassen, Supratim Choudhuri, William C. Kershaw, Lois D. Lehman-McKeeman, James M. McKim
Publikováno v:
Environmental Health Perspectives
Degradation of metallothionein (MT) from rat liver was examined. Degradation of apo-MT by liver homogenate was greater than that by cytosol. At pH 5.5, degradation by homogenate was more than that at pH 7.2. These findings suggest that proteases that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bae4e85ed375dcccc62c7bf6617af9
https://pubmed.ncbi.nlm.nih.gov/7843089
https://pubmed.ncbi.nlm.nih.gov/7843089
Autor:
William C. Kershaw, Curtis D. Klaassen
Publikováno v:
Advances in Chemistry ISBN: 9780841225176
Environmental Epidemiology: Effects of Environmental Chemicals on Human Health
Environmental Epidemiology: Effects of Environmental Chemicals on Human Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::934a69efbc19988a98ed84e0b82df7ae
https://doi.org/10.1021/ba-1994-0241.ch005
https://doi.org/10.1021/ba-1994-0241.ch005
Autor:
WILLIAM M. DRAPER, Vernon N. Houk, Gary H. Spivey, MaryFran Sowers, George Maldonado, Curtis D. Klaassen, William C. Kershaw, Arthur L. Craigmill, Scott Wetzlich, Barbara S. Shane, Michael C. Cimino, Angela E. Auletta, Marilyn F. Vine, Larry L. Needham, James A. Bond, Leslie Recio, Roger O. McClellan, John L. Wong, Bo Yuan, Peide Zhang, Carlo H. Tamburro, Elizabeth A. Grossman, Caroline S. Freeman, Michael H. Dong, Paul J. Papanek, John H. Ross, Kimberley A. Woloshin, Robert D. Stephens, Richard A. Kreutzer, David J. Hewitt, Ralph R. Cook, Sandra L. Tirey, Nanette W. Spadacene, Mary A. Woodbury, Raymond Richard Neutra