Výsledky vyhledávání - "William C. Groutas"

Akademický článek

Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

Autor: Yunjeong Kim, Emma Pool, Eunji Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Johnson, Scott Lovell, William C. Groutas, Kyeong-Ok Chang

Publikováno v: Microbiology Spectrum, Vol 12, Iss 4 (2024)

ABSTRACTFoot-and-mouth disease (FMD) is one of the most devastating diseases of livestock which can cause significant economic losses, especially when introduced to FMD-free countries. FMD virus (FMDV) belongs to the family Picornaviridae and is anti

Externí odkaz: https://doaj.org/article/7ad3fe15365b43abbcf77691f2b8c7d8

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Akademický článek

Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

Autor: Pengfei Li, Yunjeong Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Meyerholz, David K. Johnson, Scott Lovell, William C. Groutas, Stanley Perlman, Kyeong-Ok Chang

Publikováno v: mBio, Vol 15, Iss 2 (2024)

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic betacoronaviruses that continue to have a significant impact on public health. Timely development and intro

Externí odkaz: https://doaj.org/article/f79fb18ff28149f79f0191d924e8bd47

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Akademický článek

Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus

Autor: Krishani Dinali Perera, David Johnson, Scott Lovell, William C. Groutas, Kyeong-Ok Chang, Yunjeong Kim

Publikováno v: Microbiology Spectrum, Vol 10, Iss 4 (2022)

ABSTRACT Rabbit hemorrhagic disease (RHD) and European brown hare syndrome (EBHS) are highly contagious diseases caused by lagoviruses in the Caliciviridae family. These infectious diseases are associated with high mortality and a serious threat to d

Externí odkaz: https://doaj.org/article/388663d01779490a9d8a793ddc26e063

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Akademický článek

Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors

Autor: Kyeong-Ok Chang, Yunjeong Kim, Scott Lovell, Athri D. Rathnayake, William C. Groutas

Publikováno v: Viruses, Vol 11, Iss 2, p 197 (2019)

Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; consequently, host proteases have

Externí odkaz: https://doaj.org/article/02cb6503cdf6444e9d8063d68374e0c9

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Answers to Questions 491-500

Autor: William C. Groutas, Athri D. Rathnayake