Zobrazeno 1 - 10
of 20
pro vyhledávání: '"William C. Drewe"'
Autor:
Sarentha Chetty, Tom Armstrong, Shalu Sharma Kharkwal, William C. Drewe, Cristina I. De Matteis, Dimitrios Evangelopoulos, Sanjib Bhakta, Neil R. Thomas
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 361 (2021)
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This is a prodrug requiring activation by
Externí odkaz:
https://doaj.org/article/0a04b1c8e4eb420481d6dc6e82ba0b62
Autor:
François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella-Gutierrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Guney, Jan A. Kors, Miguel Angel Mayer, Manuel Pastor, Janet Piñero, Juan Manuel Ramírez-Anguita, Francesco Ronzano, Philip Rowell, Josep Saüch-Pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik van Mulligen, Ferran Sanz
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 237 (2021)
eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by usi
Externí odkaz:
https://doaj.org/article/6d356b4a5992408987f2d8a0131d3981
Autor:
Francois Pognan, Phil Drew, Nicolas Bosc, Tima Camara, Jan A. Kors, Katharine Briggs, Sirarat Sarntivijai, Manuel Pastor, William C Drewe, Thomas Steger-Hartmann, Erik M. van Mulligen, Carlos Díaz, Jordi Quintana
Publikováno v:
Altex, 38(2), 187-197. Springer International Publishing AG
ALTEX
ALTEX
Pre-competitive data sharing can offer the pharmaceutical industry significant benefits in terms of reducing the time and costs involved in getting a new drug to market through more informed testing strategies and knowledge gained by pooling data. If
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61c505267ac8b6fa0b42d47100c81a2
https://pure.eur.nl/en/publications/4b47b5e2-cf7d-45f0-830a-ba1cdcccfc95
https://pure.eur.nl/en/publications/4b47b5e2-cf7d-45f0-830a-ba1cdcccfc95
Autor:
Shalu Sharma Kharkwal, Tom Armstrong, Dimitrios Evangelopoulos, William C. Drewe, Sarentha Chetty, Cristina I. De Matteis, Neil R. Thomas, Sanjib Bhakta
Publikováno v:
Pharmaceuticals
Volume 14
Issue 4
Pharmaceuticals, Vol 14, Iss 361, p 361 (2021)
Volume 14
Issue 4
Pharmaceuticals, Vol 14, Iss 361, p 361 (2021)
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This is a prodrug requiring activation by
Autor:
Joel P. Bercu, Zhanna Sobol, John Nicolette, Patricia Parris, William C. Drewe, Krista L. Dobo
Publikováno v:
International journal of toxicology. 40(3)
A workshop entitled “Deriving Compound-Specific Exposure Limits for Chemicals Used in Pharmaceutical Synthesis” was held at the 2018 Genetic Toxicology Association annual meeting. The objectives of the workshop were to provide an educational foru
Autor:
Rachael E. Tennant, Richard V. Williams, Masamitsu Honma, Alex Cayley, Kenichi Masumura, Susanne A. Stalford, Sebastien J. Guesne, Steven J. Canipa, William C. Drewe, Takeshi Morita
Publikováno v:
Mutagenesis. 34:111-121
As part of the hazard and risk assessment of chemicals in man, it is important to assess the ability of a chemical to induce mutations in vivo. Because of the commonalities in the molecular initiating event, mutagenicity in vitro can correlate well t
Publikováno v:
Contact Dermatitis. 76:312-314
Autor:
Lilia Fisk, Valerie J. Gillet, William C. Drewe, Mukesh Patel, Jonathan D. Vessey, Steven J. Canipa, Laurence Coquin, Richard Sherhod, Jeffrey Plante
Publikováno v:
Toxicology Research. 4:46-56
Emerging pattern mining techniques have been applied to datasets of Ames mutagens. The discovered patterns give rise to clusters of compounds from large and biased datasets which are used to develop new structural alerts for mutagenicity in the Derek
Publikováno v:
Contact dermatitis. 76(5)
Autor:
Philip Bardelang, Mei Li, Lyudmila Turyanska, Tracey D. Bradshaw, Stephen Mann, Michael W. Fay, Neil R. Thomas, Amalia Patanè, William C. Drewe
Publikováno v:
J. Mater. Chem.. 22:660-665
We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigeni