Zobrazeno 1 - 10
of 289
pro vyhledávání: '"William C Little"'
Autor:
Michael L Smith, Delphine Gourdon, William C Little, Kristopher E Kubow, R Andresen Eguiluz, Sheila Luna-Morris, Viola Vogel
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e268 (2007)
Whether mechanically unfolded fibronectin (Fn) is present within native extracellular matrix fibrils is controversial. Fn extensibility under the influence of cell traction forces has been proposed to originate either from the force-induced lengtheni
Externí odkaz:
https://doaj.org/article/d2164a8d190b4b5fa0ec61180a046a93
Autor:
Daisuke Kamimura, Sartaj Hans, Takeki Suzuki, Ervin R. Fox, Michael E. Hall, Solomon K. Musani, Michael R. McMullan, William C. Little
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 10 (2016)
BackgroundTime to peak velocity (TPV) is an echocardiographic variable that can be easily measured and reflects a late peaking murmur, a classic physical finding suggesting severe aortic stenosis (AS). The aim of this study was to investigate the use
Externí odkaz:
https://doaj.org/article/5bc908dbc8ae42c29fb7337025702dfa
Autor:
Atsushi Morimoto, Nobuyuki Ohte, Hiroshi Hasegawa, Tiankai Li, David M. Herrington, William C. Little, Heng-Jie Cheng, Wei-Min Li, Che Ping Cheng
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:545-553
In heart failure (HF), the impaired left ventricular (LV) arterial coupling and diastolic dysfunction present at rest are exacerbated during exercise. C-type natriuretic peptide (CNP) is elevated in HF; however, its functional effects are unclear. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f0255310ead57174e1b4ccd6df2bc6
https://doi.org/10.1124/jpet.115.231696
https://doi.org/10.1124/jpet.115.231696
Autor:
Shin-ichi Momomura, Martin R. Cowie, Gregg C. Fonarow, Kerry L. Lee, Tracy L. Bergemann, Cecilia Linde, Anne B. Curtis, Francisco Levya, Christopher M. Manrodt, William C. Little, Anthony Tang
Publikováno v:
International Journal of Cardiology. 202:349-355
Background The benefits of CRT for symptomatic heart failure (HF) patients with a wide QRS and reduced left ventricular ejection fraction (LVEF ≤35%), are well established .Post-hoc subgroup analyses suggest that CRT benefit may extend to patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaab60244ccb029c193d11b7e217e69
Autor:
Vijay Swarup, Michael R. Zile, Rolf Wachter, Didier Klug, Fred A. Weaver, William C. Little, Seth J. Wilks, Marcel Halbach, William T. Abraham, Jochen Müller-Ehmsen, Hannes Reuter, Anique Ducharme, Michele Senni, Christian Butter, Jill E. Schafer
In a randomized trial, baroreflex activation therapy (BAT) improved exercise capacity, quality of life and NT-proBNP in patients with heart failure with reduced ejection fraction (HFrEF). In view of different mechanisms underlying HFrEF, we performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3e9ad30bb837b0068e54ee3d829db5
http://hdl.handle.net/10281/372682
http://hdl.handle.net/10281/372682
Autor:
Rolf Wachter, Jill E. Schafer, Jochen Müller-Ehmsen, Eric G. Lovett, Vijay Swarup, Fred A. Weaver, William T. Abraham, Didier Klug, Anique Ducharme, Marcel Halbach, Michael R. Zile, Michele Senni, Christian Butter, William C. Little
Publikováno v:
JACC: Heart Failure. 3:487-496
Objectives: The objective of this clinical trial was to assess the safety and efficacy of carotid BAT in advanced HF. Background: Increased sympathetic and decreased parasympathetic activity contribute to heart failure (HF) symptoms and disease progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef1ea212600d7266262924dd90a0713
https://doi.org/10.1016/j.jchf.2015.02.006
https://doi.org/10.1016/j.jchf.2015.02.006
Publikováno v:
Journal of Cardiovascular Translational Research. 8:54-58
The diastolic intraventricular ring vortex formation and pinch-off process may provide clinically useful insights into diastolic function in health and disease. The vortex ring formation time (FT) concept, based on hydrodynamic experiments dealing wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0ca88170b6ea06db614b456dbf97d6
https://doi.org/10.1007/s12265-015-9607-7
https://doi.org/10.1007/s12265-015-9607-7
Autor:
William C. Little, Barry A. Borlaug
Publikováno v:
Circulation: Heart Failure. 8:233-235
Heart failure (HF) occurs when the cardiac output is unable to meet the body’s needs without an elevated filling pressure.1,2 Thus, exercise intolerance is an important symptomatic manifestation of HF, including patients with HF and a preserved eje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3828d4c6c7eb8497537f7afc22491ac7
https://doi.org/10.1161/circheartfailure.114.001966
https://doi.org/10.1161/circheartfailure.114.001966
Autor:
Hiroshi Hasegawa, Qing-Hua Han, Heng-Jie Cheng, Atsushi Morimoto, Satoshi Masutani, Che Ping Cheng, William C. Little
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H923-H930
In heart failure (HF), the impaired left ventricular (LV) arterial coupling and diastolic dysfunction present at rest are exacerbated during exercise. We have previously shown that in HF at rest stimulation of β3-adrenergic receptors by endogenous c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce65c60431ebcdb870104a59d6e98792
https://doi.org/10.1152/ajpheart.00371.2012
https://doi.org/10.1152/ajpheart.00371.2012
Autor:
William C. Little, Sangeeta Mandapaka, Timothy M. Morgan, Charaslak Charoenpanichkit, W. Gregory Hundley, Craig A. Hamilton, Erica Dall'Armellina
OBJECTIVES: The purpose of this study was to determine whether dobutamine-induced abnormal stress changes in left ventricular stroke volume (LVSV) and aortic stiffness predict future pulmonary edema. BACKGROUND: Increased aortic stiffness that decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3a8c1932e9ca9f6dfe773c77ba9696
https://ora.ox.ac.uk/objects/uuid:49198a0b-8f69-4f0e-8047-95d82b2bae8f
https://ora.ox.ac.uk/objects/uuid:49198a0b-8f69-4f0e-8047-95d82b2bae8f