Zobrazeno 1 - 10
of 32
pro vyhledávání: '"William C L Stewart"'
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232300 (2020)
In linear regression, a residual measures how far a subject's observation is from expectation; in survival analysis, a subject's Martingale or deviance residual is sometimes interpreted similarly. Here we consider ways in which a linear regression-li
Externí odkaz:
https://doaj.org/article/04697df9db1a4613abbb5dbcda0eeb73
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234910 (2020)
Aging in mammals is the gradual decline of an organism's physical, mental, and physiological capacity. Aging leads to increased risk for disease and eventually to death. Here, we show that Brd2 haploinsufficiency (Brd2+/-) extends lifespan and increa
Externí odkaz:
https://doaj.org/article/bfc24dbe204a4db791e5e53d0e6cee8c
Autor:
William C L Stewart, Jane eCerise
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
When studying the genetics of inherited diseases, researchers often collect data on affected families, unrelated cases, and healthy controls. However, the joint analysis of such heterogeneous data is difficult, and the simpler analysis of homogeneous
Externí odkaz:
https://doaj.org/article/f708018813cd4a6fac3c66ddbe850f02
BioNetGMMFit: estimating parameters of a BioNetGen model from time-stamped snapshots of single cells
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Mechanistic models are commonly employed to describe signaling and gene regulatory kinetics in single cells and cell populations. Recent advances in single-cell technologies have produced multidimensional datasets where snapshots of copy num
Externí odkaz:
https://doaj.org/article/b035828b037b46c8b533329d18eb43e5
Autor:
Ryan L Subaran, William C. L. Stewart
Publikováno v:
Human Mutation. 41:2078-2086
As whole-genome data become available for increasing numbers of individuals across diverse populations, the list of genomic variants of unknown significance (VOUS) continues to grow. One powerful tool in VOUS interpretation is determining whether an
Autor:
Irina A. Buhimschi, William C. L. Stewart, Mark A. Klebanoff, Komla M Gnona, Ben Kelly, Peter White, Leif D. Nelin
Publikováno v:
Pediatric Research. 88:653-660
Preterm birth is the leading cause of mortality and morbidity in young children, with over a million deaths per year worldwide arising from neonatal complications (NCs). NCs are moderately heritable although the genetic causes are largely unknown. Th
Autor:
Komla M Gnona, William C L Stewart
Publikováno v:
American journal of epidemiology. 191(8)
The Wald test is routinely used in case-control studies to test for association between a covariate and disease. However, when the evidence for association is high, the Wald test tends to inflate small P values as a result of the Hauck-Donner effect
Autor:
Don Hayes, Dmitry Tumin, William C. L. Stewart, Rebecca Miller, Joseph D. Tobias, Susan S. Li
Publikováno v:
Chest. 156:64-70
Background The lung allocation score (LAS) prioritizes lung transplant (LTx) candidates with poor transplant-free survival and expected survival benefit from LTx. Although patients with the highest LAS have the shortest waiting time, mortality benefi
Publikováno v:
BMC Proceedings, Vol 12, Iss S9, Pp 163-167 (2018)
Because of the limited information from the GAW20 samples when only case-control or trio data are considered, we propose eLBL, an extension of the Logistic Bayesian LASSO (least absolute shrinkage and selection operator) methodology so that both type
Autor:
William C L, Stewart, Komla M, Gnona, Peter, White, Ben, Kelly, Mark, Klebanoff, Irina A, Buhimschi, Leif D, Nelin
Publikováno v:
Pediatric research. 88(4)
Preterm birth is the leading cause of mortality and morbidity in young children, with over a million deaths per year worldwide arising from neonatal complications (NCs). NCs are moderately heritable although the genetic causes are largely unknown. Th