Zobrazeno 1 - 10
of 58
pro vyhledávání: '"William C L Stewart"'
BioNetGMMFit: estimating parameters of a BioNetGen model from time-stamped snapshots of single cells
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Mechanistic models are commonly employed to describe signaling and gene regulatory kinetics in single cells and cell populations. Recent advances in single-cell technologies have produced multidimensional datasets where snapshots of copy num
Externí odkaz:
https://doaj.org/article/b035828b037b46c8b533329d18eb43e5
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232300 (2020)
In linear regression, a residual measures how far a subject's observation is from expectation; in survival analysis, a subject's Martingale or deviance residual is sometimes interpreted similarly. Here we consider ways in which a linear regression-li
Externí odkaz:
https://doaj.org/article/04697df9db1a4613abbb5dbcda0eeb73
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234910 (2020)
Aging in mammals is the gradual decline of an organism's physical, mental, and physiological capacity. Aging leads to increased risk for disease and eventually to death. Here, we show that Brd2 haploinsufficiency (Brd2+/-) extends lifespan and increa
Externí odkaz:
https://doaj.org/article/bfc24dbe204a4db791e5e53d0e6cee8c
Publikováno v:
BMC Proceedings, Vol 12, Iss S9, Pp 163-167 (2018)
Abstract Because of the limited information from the GAW20 samples when only case-control or trio data are considered, we propose eLBL, an extension of the Logistic Bayesian LASSO (least absolute shrinkage and selection operator) methodology so that
Externí odkaz:
https://doaj.org/article/61105b84225b4a71b2e899f16f2879eb
Publikováno v:
Royal Society Open Science, Vol 5, Iss 11 (2018)
Otitis media (OM) is a common polymicrobial infection of the middle ear in children under the age of 15 years. A widely used experimental strategy to analyse roles of specific phenotypes of bacterial pathogens of OM is to study changes in co-infectio
Externí odkaz:
https://doaj.org/article/48eeb41e3bfc481bae6f9068c1bf39e1
Autor:
Meng Wang, William C. L. Stewart
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
The efficient analysis of hybrid designs [e.g., affected families, controls, and (optionally) independent cases] is attractive because it should have increased power to detect associations between genetic variants and disease. However, the computatio
Externí odkaz:
https://doaj.org/article/81a128390d374b239d45d339be1fbcdb
Autor:
Ryan L Subaran, William C. L. Stewart
Publikováno v:
Human Mutation. 41:2078-2086
As whole-genome data become available for increasing numbers of individuals across diverse populations, the list of genomic variants of unknown significance (VOUS) continues to grow. One powerful tool in VOUS interpretation is determining whether an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4e6c86a2dd48d061af9a5489294e2b
https://doi.org/10.1002/humu.24123
https://doi.org/10.1002/humu.24123
Autor:
Irina A. Buhimschi, William C. L. Stewart, Mark A. Klebanoff, Komla M Gnona, Ben Kelly, Peter White, Leif D. Nelin
Publikováno v:
Pediatric Research. 88:653-660
Preterm birth is the leading cause of mortality and morbidity in young children, with over a million deaths per year worldwide arising from neonatal complications (NCs). NCs are moderately heritable although the genetic causes are largely unknown. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::188f39155a45f0767d88cce9917687ba
https://doi.org/10.1038/s41390-020-0796-7
https://doi.org/10.1038/s41390-020-0796-7
Autor:
Komla M Gnona, William C L Stewart
Publikováno v:
American journal of epidemiology. 191(8)
The Wald test is routinely used in case-control studies to test for association between a covariate and disease. However, when the evidence for association is high, the Wald test tends to inflate small P values as a result of the Hauck-Donner effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0211de3b5e4d69b68bf6487d11e0c1
https://pubmed.ncbi.nlm.nih.gov/35355063
https://pubmed.ncbi.nlm.nih.gov/35355063
Autor:
Don Hayes, Dmitry Tumin, William C. L. Stewart, Rebecca Miller, Joseph D. Tobias, Susan S. Li
Publikováno v:
Chest. 156:64-70
Background The lung allocation score (LAS) prioritizes lung transplant (LTx) candidates with poor transplant-free survival and expected survival benefit from LTx. Although patients with the highest LAS have the shortest waiting time, mortality benefi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be3e6cb79ae626e856b6cf2346c8063
https://doi.org/10.1016/j.chest.2019.01.008
https://doi.org/10.1016/j.chest.2019.01.008