Zobrazeno 1 - 10
of 12
pro vyhledávání: '"William C Knight"'
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 4, Pp 867-874 (2022)
Neurodegenerative diseases are a class of chronic and complex disorders featuring progressive loss of neurons in distinct brain areas. The mechanisms responsible for the disease progression in neurodegeneration are not fully illustrated. In this obse
Externí odkaz:
https://doaj.org/article/757108dff61f4c69818f57330e75fe22
Autor:
Jinbin Xu, Huifangjie L. Farsad, Yiran Hou, Kia Barclay, Ben Anthony Lopez, Shinnosuke Yamada, Ibrahim Olabayode Saliu, Yiming Shi, William C. Knight, Randall J. Bateman, Tammie L. S. Benzinger, Jason J. Yi, Qingyun Li, Ting Wang, Joel S. Perlmutter, John C. Morris, Guoyan Zhao
Publikováno v:
Nat Aging
The commonalities and differences in cell-type-specific pathways that lead to Alzheimer disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single-nucleus transcriptome comparison of control, AD and PD striata. We describe th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053a1e2b202f80a699b9c2f7588794f2
https://doi.org/10.1038/s43587-023-00363-8
https://doi.org/10.1038/s43587-023-00363-8
Autor:
Huifangjie Li, William C. Knight, Pengfei Yang, Yingqiu Guo, Joel S. Perlmutter, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, Jinbin Xu
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6047 (2020)
We found interactions between dopamine and oxidative damage in the striatum involved in advanced neurodegeneration, which probably change the microglial phenotype. We observed possible microglia dystrophy in the striatum of neurodegenerative brains.
Externí odkaz:
https://doaj.org/article/76ef6ee4e0df4736a04f742003a30091
Autor:
Pengfei Yang, Joel S. Perlmutter, Jinbin Xu, William C Knight, Huifangjie Li, John C. Morris, Yingqiu Guo, Tammie L.S. Benzinger
Publikováno v:
Annals of Clinical and Translational Neurology
Objective Dopamine D2‐like receptors – mainly dopamine D2 receptors (D2R) and dopamine D3 receptors (D3R) – are believed to be greatly involved in the pathology of Parkinson disease (PD) progression. However, these receptors have not been preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db86aad0e9f72d30eb6d0d01f48c5384
https://doi.org/10.1002/acn3.51274
https://doi.org/10.1002/acn3.51274
Autor:
Jinbin Xu, Joel S. Perlmutter, Yingqiu Guo, William C Knight, Pengfei Yang, John C. Morris, Tammie L.S. Benzinger, Huifangjie Li
Publikováno v:
Journal of Neurochemistry
The striatum with a number of dopamine containing neurons, receiving projections from the substantia nigra and ventral tegmental area; plays a critical role in neurodegenerative diseases of motor and memory function. Additionally, oxidative damage to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1993db1aea4eb8685e267215a40341a9
http://europepmc.org/articles/PMC6981021
http://europepmc.org/articles/PMC6981021
Autor:
John C. Morris, Randall J. Bateman, Pengfei Yang, Huifangjie Li, Jinbin Xu, Yingqiu Guo, Tammie L.S. Benzinger, Joel S. Perlmutter, William C Knight
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 17
International Journal of Molecular Sciences, Vol 21, Iss 6047, p 6047 (2020)
Volume 21
Issue 17
International Journal of Molecular Sciences, Vol 21, Iss 6047, p 6047 (2020)
We found interactions between dopamine and oxidative damage in the striatum involved in advanced neurodegeneration, which probably change the microglial phenotype. We observed possible microglia dystrophy in the striatum of neurodegenerative brains.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5ae25aa0e36a4e74f7c31972546e6c
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 4, Pp 867-874 (2022)
Neural Regeneration Research
Neural Regeneration Research
Neurodegenerative diseases are a class of chronic and complex disorders featuring progressive loss of neurons in distinct brain areas. The mechanisms responsible for the disease progression in neurodegeneration are not fully illustrated. In this obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c985e3f85b5f706019206ba1baa8b
https://doi.org/10.4103/1673-5374.322463
https://doi.org/10.4103/1673-5374.322463
Publikováno v:
Parkinsonism & Related Disorders. 79:e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df6db974371ac3a583ce165e3d353b2
https://doi.org/10.1016/j.parkreldis.2020.06.046
https://doi.org/10.1016/j.parkreldis.2020.06.046
Autor:
Nikolaos Biris, Agostinho G. Rocha, James W. Janetka, Justin M. Alberti, Andrzej M. Krezel, Jeanne M. Rumsey, Evripidis Gavathiotis, Richard N. Kitsis, Antonietta Franco, Emmanouil Zacharioudakis, Daria Mochly-Rosen, Robert H. Baloh, Raymond R. Townsend, William C Knight, Gerald W. Dorn
An innovative approach for a rare disease Charcot-Marie-Tooth disease type 2A (CMT2A) is a rare, inherited neurodegenerative condition. Affected individuals develop severe progressive muscle weakness, motor deficits, and peripheral neuropathy. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2996cb59aa8784525e3e6ebeb02263bb
https://europepmc.org/articles/PMC6109362/
https://europepmc.org/articles/PMC6109362/
Autor:
Thomas Klein, James R. Sowers, Javad Habibi, Ravi Nistala, Vincent G. DeMarco, Adam Whaley-Connell, Tamara S. Hancock, Melvin R. Hayden, Alex Meuth, William C Knight, Annayya R. Aroor
Publikováno v:
Obesity. 22:2172-2179
Objective Obesity-related glomerulopathy is characterized initially by glomerular hyperfiltration with hypertrophy and then development of proteinuria. Putative mechanisms include endothelial dysfunction and filtration barrier injury due to oxidant s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0aaf12e1070143d3f5473785c8ba4d
https://doi.org/10.1002/oby.20833
https://doi.org/10.1002/oby.20833