Zobrazeno 1 - 10
of 164
pro vyhledávání: '"William C Eward"'
Autor:
Mark M. Cullen, Alexander L. Lazarides, Patricia D. Pittman, Etienne M. Flamant, Kathryn L. Stoeber, Kai Stoeber, Julia D. Visguass, Brian E. Brigman, Richard F. Riedel, Diana M. Cardona, Jason A. Somarelli, William C. Eward
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Purpose Loddo et al. (Br J Cancer 100:959–70, 2009) established the prognostic significance of cell cycle markers and "Cell-Cycle Phenotypes" in breast carcinoma. This study aims to 1) identify prognostic cell-cycle markers in sarcoma, and
Externí odkaz:
https://doaj.org/article/e9aecc8e88cd43fd9bfc3864124d0eae
Autor:
Kevin A. Wu, Devika Shenoy, Elizabeth Sachs, Jason A. Somarelli, Christian Pean, Malcolm DeBaun, Brian E. Brigman, Julia D. Visgauss, William C. Eward
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Orthopedic procedures often require removing bone or pathological tissue, with traditional methods involving instruments like curettes and rongeurs. However, these methods can be time-consuming and lead to increased blood loss. To
Externí odkaz:
https://doaj.org/article/022972d015e44269a5207e5016901d96
Autor:
Jeffrey K Mito, Richard F Riedel, Leslie Dodd, Guy Lahat, Alexander J Lazar, Rebecca D Dodd, Lars Stangenberg, William C Eward, Francis J Hornicek, Sam S Yoon, Brian E Brigman, Tyler Jacks, Dina Lev, Sayan Mukherjee, David G Kirsch
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8075 (2009)
Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model
Externí odkaz:
https://doaj.org/article/fc952ffe86de48899cb910a834bd347e
Autor:
Alexander L. Lazarides, Bijan Abar, Bruce Leckey, John T. Martin, Evelyna G. Kliassov, Brian E. Brigman, William C. Eward, Diana M. Cardona, Julia D. Visgauss
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Cartilaginous neoplasms can be challenging to grade; there is a need to create an evidence-based rubric for grading. The goal of this study was to identify histopathologic features of chondrosarcoma that were associated with 5-yea
Externí odkaz:
https://doaj.org/article/c43626c4778343658417837e35baa1e6
Autor:
Mark M. Cullen, Warren Floyd, Bobby Dow, Beatrice Schleupner, Brian E. Brigman, Julia D. Visgauss, Diana M. Cardona, Jason A. Somarelli, William C. Eward
Publikováno v:
Sarcoma, Vol 2024 (2024)
Purpose. Recently, the association between ATRX and a more aggressive sarcoma phenotype has been shown. We performed a retrospective study of sarcomas from an individual institution to evaluate ATRX as a prognosticator in soft tissue sarcoma. Experim
Externí odkaz:
https://doaj.org/article/44de99e458b647a394329419d9930cfa
Autor:
Warren Floyd, Matthew Pierpoint, Chang Su, Rutulkumar Patel, Lixia Luo, Katherine Deland, Amy J. Wisdom, Daniel Zhu, Yan Ma, Suzanne Bartholf DeWitt, Nerissa T. Williams, Alexander L. Lazarides, Jason A. Somarelli, David L. Corcoran, William C. Eward, Diana M. Cardona, David G. Kirsch
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially frequent in soft tissue sarcomas. However, the role of ATRX in tumor development and response to cancer therapies remains poorly understood. Here, we develop
Externí odkaz:
https://doaj.org/article/cf22b262f28e4e4f8995c26c529b117e
Autor:
Rachel Karasik, Nancy E. Lauer, Anne-Elisabeth Baker, Niki E. Lisi, Jason A. Somarelli, William C. Eward, Kathinka Fürst, Meagan M. Dunphy-Daly
Publikováno v:
Frontiers in Marine Science, Vol 9 (2023)
Plastic heterogeneously affects social systems – notably human health and local and global economies. Here we discuss illustrative examples of the benefits and burdens of each stage of the plastic lifecycle (e.g., macroplastic production, consumpti
Externí odkaz:
https://doaj.org/article/2e78c5abb3964237b0d91f129d630d87
Autor:
Zoie Diana, Rachel Karasik, Greg B. Merrill, Margaret Morrison, Kimberly A. Corcoran, Daniel Vermeer, Evan Hepler-Smith, Nishad Jayasundara, Jeremy Pare, John Virdin, William C. Eward, Jason A. Somarelli, Meagan M. Dunphy-Daly, Daniel Rittschof
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/37e45fd83b8344729440cfa2f5c66b93
Autor:
Suzanne Bartholf DeWitt, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E.J. Martz, Maryam Zand, Vardhman Kumar, Maya U. Sheth, Warren Floyd, Jacob V. Spruance, Nathan Hawkey, Shyni Varghese, Jianhua Ruan, David G. Kirsch, Jason A. Somarelli, Ben Alman, William C. Eward
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phe
Externí odkaz:
https://doaj.org/article/f0b8ac4838164adeb418e251226c29eb
Autor:
Tyler A. Allen, Mark M. Cullen, Nathan Hawkey, Hiroyuki Mochizuki, Lan Nguyen, Elyse Schechter, Luke Borst, Jeffrey A. Yoder, Jennifer A. Freedman, Steven R. Patierno, Ke Cheng, William C. Eward, Jason A. Somarelli
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Metastasis is a multistep process in which cells must detach, migrate/invade local structures, intravasate, circulate, extravasate, and colonize. A full understanding of the complexity of this process has been limited by the lack of ability to study
Externí odkaz:
https://doaj.org/article/529bbd20dab947d0902ce121f8d74ea4