Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore

Autor: Bram Prevo, Dhanya K. Cheerambathur, William C. Earnshaw, Arshad Desai

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Multiple microtubule-directed activities concentrate on mitotic chromosomes to ensure their faithful segregation. These include couplers and dynamics regulators localized at the kinetochore, the microtubule interface built on centromeric chr

Externí odkaz: https://doaj.org/article/9194aac344124d20b7a3b93d51bd888c

Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

Autor: Daniel G Booth, Masatoshi Takagi, Luis Sanchez-Pulido, Elizabeth Petfalski, Giulia Vargiu, Kumiko Samejima, Naoko Imamoto, Chris P Ponting, David Tollervey, William C Earnshaw, Paola Vagnarelli

Publikováno v: eLife, Vol 3 (2014)

When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment coating the chromosome periphery. At present nothing is known about the function of this poor

Externí odkaz: https://doaj.org/article/b63768057a194e75bbe34fafe5bca9fa

The chromosomal passenger complex activates Polo kinase at centromeres.

Autor: Mar Carmena, Xavier Pinson, Melpi Platani, Zeina Salloum, Zhenjie Xu, Anthony Clark, Fiona Macisaac, Hiromi Ogawa, Ulrike Eggert, David M Glover, Vincent Archambault, William C Earnshaw

Publikováno v: PLoS Biology, Vol 10, Iss 1, p e1001250 (2012)

The coordinated activities at centromeres of two key cell cycle kinases, Polo and Aurora B, are critical for ensuring that the two sister kinetochores of each chromosome are attached to microtubules from opposite spindle poles prior to chromosome seg

Externí odkaz: https://doaj.org/article/d44a914551df4c03a4a1351d1a6845ce

Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli

Autor: Mikhail Liskovykh, Nikolai S. Petrov, Vladimir N. Noskov, Hiroshi Masumoto, William C. Earnshaw, David Schlessinger, Svetlana A. Shabalina, Vladimir Larionov, Natalay Kouprina

Publikováno v: Liskovykh, M, Petrov, N S, Noskov, V N, Masumoto, H, Earnshaw, W C, Schlessinger, D, Shabalina, S A, Larionov, V & Kouprina, N 2023, ' Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli ', Cellular and Molecular Life Sciences, vol. 80, no. 5, 121 . https://doi.org/10.1007/s00018-023-04770-3

Although they are organelles without a limiting membrane, nucleoli have an exclusive structure, built upon the rDNA-rich acrocentric short arms of five human chromosomes (nucleolar organizer regions or NORs). This has raised the question: what are th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c6d0a17bc08a5f209032b9cf607d0c
https://hdl.handle.net/20.500.11820/bf60b92a-f13e-4419-90da-6aaf6adb3a3a

Supplementary Data from Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

Autor: Natalay Kouprina, Vladimir Larionov, William C. Earnshaw, Yves Pommier, Marie-Paule Teulade-Fichou, Hiroshi Masumoto, Mitsuo Oshimura, Jung-Hyun Kim, Emma Peat, Mikhail Liskovykh, Mar Carmena, Hee-Sheung Lee

14 Supplementary Figures and 2 Supplementary Tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6369effd13b0cd3a51d724d4b82293
https://doi.org/10.1158/0008-5472.22420032