Zobrazeno 1 - 10
of 12
pro vyhledávání: '"William C, Gunther"'
Publikováno v:
Environmental and Molecular Mutagenesis. 59:312-321
2-Hydroxypyridine-N-oxide (HOPO) is a useful coupling reagent for synthesis of active pharmaceutical ingredients. It has been reported to be weakly mutagenic in the Ames assay (Ding W et al. []: J Chromatogr A 1386:47-52). According to the ICH M7 gui
Publikováno v:
Environmental and Molecular Mutagenesis.
2-Hydroxypyridine N-oxide (HOPO) is an important coupling reagent used in pharmaceutical synthesis. Our laboratory previously reported HOPO as equivocal in the Ames assay following extensive testing of multiple lots of material. Given the lack of rep
Publikováno v:
Environmental and molecular mutagenesis. 59(4)
2-Hydroxypyridine-N-oxide (HOPO) is a useful coupling reagent for synthesis of active pharmaceutical ingredients. It has been reported to be weakly mutagenic in the Ames assay (Ding W et al. []: J Chromatogr A 1386:47-52). According to the ICH M7 gui
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 91
The ICH M7 Guideline requires low level control of mutagenic impurities in pharmaceutical products to minimize cancer risk in patients (ICHM7, 2014). Bacterial mutagenicity (Ames) data is generally used to determine mutagenic and possible carcinogeni
Autor:
Susan D. O'Lone, Maria Engel, Ronald D. Fiedler, Maik Schuler, Kelley E. Sanok, Krista L. Dobo, Catherine J. Thiffeault, Stephanie L. Coffing, Donna A. Dickinson, William C. Gunther, Thomas J. Shutsky
Publikováno v:
Environmental and Molecular Mutagenesis. 55:492-499
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Autor:
Zoryana Cammerer, Maik Schuler, Ronald D. Fiedler, Stephanie L. Coffing, Catherine J. Thiffeault, Krista L. Dobo, Thomas J. Shutsky, William C. Gunther
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 725:13-21
In recent years, experimental evidence has accumulated that supports the existence of sublinear dose–response relationships at low doses of DNA reactive mutagens. However, creating the in vivo data necessary to allow for a more detailed dose–resp
Autor:
William C. Gunther, Ann Schuermans, John Nicolette, Fabrice Nesslany, Ronald D. Fiedler, Stephen D. Dertinger, Céline Defrain, Laura Custer, Thomas J. Shutsky, Catherine J. Thiffeault, Robert H. Heflich, Paul Sonders, Amanda Giddings, Ljubica Krsmanovic, Javed A. Bhalli, Eleanor C. Wilde, Anthony M. Lynch, James T. MacGregor, Kevin Sweder, Osamu Tajima, Takafumi Kimoto, Andrew Henwood, Jing Shi, Terry Van Doninck, Souk Phonethepswath, Carol Gleason, Bas-jan M. van der Leede, Hans-Werner Vohr, Daniel J. Roberts, Pamela Weller, Azeddine Elhajouji, Yoshie Hiwata, Leon F. Stankowski, Joel Murray, Julia Kenny, Kentaro Tanaka
Publikováno v:
Environmental and Molecular Mutagenesis. 52:690-698
A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Four
Autor:
Susan D. O'Lone, Krista L. Dobo, William C. Gunther, Richard A. Spellman, Maik Schuler, Paula A. Muehlbauer, Claudia J. Wiersch, Kelley E. Sanok
Publikováno v:
Environmental and Molecular Mutagenesis. 49:318-327
Previously, this laboratory reported on the development of a flow cytometry-based method that automates the assessment of the mitotic index (MI) and numerical chromosome changes in chemically treated cultures of human lymphocytes [Muehlbauer PA and S
Autor:
Stephanie L. Coffing, Krista L. Dobo, William C. Gunther, Joel I. Ackerman, Michelle O. Kenyon, Stephen D. Dertinger, Kay Criswell
Publikováno v:
Mutagenesis. 30(3)
The Pig-a assay has rapidly gained international interest as a useful tool for assessing the mutagenic potential of compounds in vivo. Although a large number of compounds, including both mutagens and non-mutagens, have been tested in the rat Pig-a a
Autor:
William C, Gunther, Stephanie L, Coffing, Donna A, Dickinson, Maria E, Engel, Ronald D, Fiedler, Susan D, O'Lone, Kelley E, Sanok, Catherine J, Thiffeault, Thomas J, Shutsky, Maik J, Schuler, Krista L, Dobo
Publikováno v:
Environmental and molecular mutagenesis. 55(6)
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12