Zobrazeno 1 - 10
of 61
pro vyhledávání: '"William C, Griffin"'
Autor:
Jacqueline S. Womersley, Clémence Obellianne, Audrey E. Padula, Marcelo F. Lopez, William C. Griffin, Lauren E. Ball, Stefano Berto, Kathleen A. Grant, Danyelle M. Townsend, Joachim D. Uys, Patrick J. Mulholland
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117514- (2024)
Alcohol use disorder (AUD) is the most prevalent substance use disorder but there is incomplete knowledge of the underlying molecular etiology. Here, we examined the cytosolic proteome from the nucleus accumbens core (NAcC) of ethanol drinking rhesus
Externí odkaz:
https://doaj.org/article/065fd24f7c074ee98ae105b126d2ddbc
Publikováno v:
Alcohol. 106:44-54
Examining neural circuits underlying persistent, heavy drinking provides insight into the neurobiological mechanisms driving alcohol use disorder. Facilitated by its connectivity with other parts of the brain such as the nucleus accumbens (NAc), the
Autor:
Harold L. Haun, Christina L. Lebonville, Matthew G. Solomon, William C. Griffin, Marcelo F. Lopez, Howard C. Becker
Publikováno v:
Biol Psychiatry
While there is high comorbidity of stress-related disorders and alcohol use disorder, few effective treatments are available and elucidating underlying neurobiological mechanisms has been hampered by a general lack of reliable animal models. Here, we
Publikováno v:
Neuropsychopharmacology
Preclinical and clinical evidence suggests that exogenous administration of oxytocin (OT) may hold promise as a therapeutic strategy for reducing heavy alcohol drinking. However, it remains unknown whether these effects are mediated by stimulation of
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Repeated cycles of chronic intermittent ethanol (CIE) exposure increase voluntary consumption of ethanol in mice. Previous work has shown that extracellular glutamate in the nucleus accumbens (NAc) is significantly elevated in ethanol dependent mice
Externí odkaz:
https://doaj.org/article/c341935ec8e74ffc9af3b57c275310c4
Autor:
Harold L. Haun, Rachel I. Anderson, Howard C. Becker, William C. Griffin, Thomas L. Kash, Marcelo F. Lopez, Daniel W. Bloodgood, Dipanwita Pati, Kristen M. Boyt
Publikováno v:
Neuropsychopharmacology
Although previous research has demonstrated a role for kappa opioid receptor-mediated signaling in escalated alcohol consumption associated with dependence and stress exposure, involvement of the dynorphin/kappa opioid receptor (DYN/KOR) system in bi
Autor:
Katharina E. Koch, Christina E. May, Anne C.K. Olsen, Harold L. Haun, Lauryn N. Luderman, William C. Griffin
Publikováno v:
Alcohol
Mixing alcohol (ethanol) with caffeinated beverages continues to be a common and risky practice. Energy drinks are one type of caffeinated beverage that may be especially problematic when used as mixers, due to their relatively high caffeine content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812d953fd9ba290d540a89aa15dbc264
https://europepmc.org/articles/PMC8206008/
https://europepmc.org/articles/PMC8206008/
Autor:
Lori A. Knackstedt, William C. Griffin, Patrick J. Mulholland, Howard C. Becker, Harold L. Haun, Vorani Ramachandra
Publikováno v:
Alcohol
Repeated cycles of chronic intermittent ethanol (CIE) exposure increase voluntary consumption of alcohol (ethanol) in mice. Previous reports from our laboratory show that CIE increases extracellular glutamate in the nucleus accumbens (NAc) and that m
Publikováno v:
Neuropharmacology
Binge drinking is the most common pattern of excessive alcohol consumption and is a significant contributor to the development of Alcohol Use Disorder and dependence. Previous studies demonstrated involvement of kappa opioid receptors (KOR) in binge-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dce6c0a69cda3ba1044ed2d4c0d3c2b
https://europepmc.org/articles/PMC7080606/
https://europepmc.org/articles/PMC7080606/
Autor:
William C. Griffin, Courtney E. King, Jacqueline F. McGinty, Malcolm M. Kates, Howard C. Becker, Lauryn N. Luderman
Publikováno v:
Alcoholism: Clinical and Experimental Research. 41:955-964
Background Excessive ethanol consumption remains an important health concern and effective treatments are lacking. The central oxytocin system has emerged as a potentially important therapeutic target for alcohol and drug addiction. These studies tes