Zobrazeno 1 - 10
of 22
pro vyhledávání: '"William Burgan"'
Autor:
Debanjan Goswami, De Chen, Yue Yang, Prabhakar R Gudla, John Columbus, Karen Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell, William Burgan, Vanessa Wall, Dominic Esposito, Dhirendra K Simanshu, Felice C Lightstone, Dwight V Nissley, Frank McCormick, Thomas Turbyville
Publikováno v:
eLife, Vol 9 (2020)
The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-dom
Externí odkaz:
https://doaj.org/article/c798200b000d4c1ab8ba16fab0ce9c68
Autor:
Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1889-1902 (2018)
Summary: KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3′ kinase, and RalGDS families, but many additional direct and indirect effectors have been
Externí odkaz:
https://doaj.org/article/b9acf930ce7f49cbbf8886d56ca37592
Autor:
Frank McCormick, Dwight V. Nissley, Serguei V. Kozlov, Theresa M. Guerin, Ming Yi, William Burgan, Pavan P. Adiseshaiah, Debanjan Goswami, Suman Mukhopadhyay
Metabolic Pathway Enrichment in PDAC Patients Treated with Gemcitabine (Data Pooled from TCGA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a53c39d6003072e7883ee7a58d93261
https://doi.org/10.1158/0008-5472.22424965.v1
https://doi.org/10.1158/0008-5472.22424965.v1
Autor:
Frank McCormick, Dwight V. Nissley, Serguei V. Kozlov, Theresa M. Guerin, Ming Yi, William Burgan, Pavan P. Adiseshaiah, Debanjan Goswami, Suman Mukhopadhyay
Effects of glutamine deprivation on cell viability and NRF2 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534a06a0ecd399641f2b287bd0c89795
https://doi.org/10.1158/0008-5472.22424977
https://doi.org/10.1158/0008-5472.22424977
Autor:
Frank McCormick, Dwight V. Nissley, Serguei V. Kozlov, Theresa M. Guerin, Ming Yi, William Burgan, Pavan P. Adiseshaiah, Debanjan Goswami, Suman Mukhopadhyay
Pancreatic cancer is a disease with limited therapeutic options. Resistance to chemotherapies poses a significant clinical challenge for patients with pancreatic cancer and contributes to a high rate of recurrence. Oncogenic KRAS, a critical driver o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f74becc83f778771668a06ebea7d9c0
https://doi.org/10.1158/0008-5472.c.6511915.v1
https://doi.org/10.1158/0008-5472.c.6511915.v1
Autor:
Frank McCormick, Dwight V. Nissley, Serguei V. Kozlov, Theresa M. Guerin, Ming Yi, William Burgan, Pavan P. Adiseshaiah, Debanjan Goswami, Suman Mukhopadhyay
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf169457049e279238fb75e71e964fc
https://doi.org/10.1158/0008-5472.22425001.v1
https://doi.org/10.1158/0008-5472.22425001.v1
Autor:
Hannah Price, Stacey Stauffer, Katie Powell, Andrew Baker, Andrew Perciaccante, Edjay Ralph Hernandez, Patience Odeniyide, Christine Pratilas, William Burgan, Lisa Jenkins, Kent L. Rossman, Marielle Yohe
Publikováno v:
Molecular Cancer Research. 21:B038-B038
Directly targeting RAS is a desirable approach for treating RAS-mutated tumors because direct RAS inhibitors block all RAS effector pathways simultaneously. Recently, several groups have developed agents that directly target KRAS by covalently modify
Autor:
Caroline J. DeHart, Robert A. D'Ippolito, Kanika Sharma, Nicole Fer, Brian Smith, Mackenzie Meyer, Scott Eury, Abigail Neish, Katie Powell, Vanessa Wall, William Burgan, Dominic Esposito, Anna E. Maciag, Frank McCormick, Dwight V. Nissley
Publikováno v:
Molecular Cancer Research. 21:A016-A016
The RAS family of GTPases (HRAS, KRAS4A, KRAS4B, NRAS) provide a formidable challenge to standard proteomic workflows. Linking key N-terminal mutations (e.g., G12C, G13D) with C-terminal post-translational modifications (PTMs) on a given RAS isoform
Autor:
Lick Pui Lai, Nicole Fer, William Burgan, Vanessa E. Wall, Bingfang Xu, Daniel Soppet, Dominic Esposito, Dwight V. Nissley, Frank McCormick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 5
RAF inhibitors unexpectedly induce ERK signaling in normal and tumor cells with elevated RAS activity. Paradoxical activation is believed to be RAS dependent. In this study, we showed that LY3009120, a pan-RAF inhibitor, can unexpectedly cause parado
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(10 Pt 1)
Current strategies for tumor cell radiosensitization focus on a target-based approach. However, the radioresponse of a tumor cell is influenced by a wide variety of signaling molecules existing in a number of different survival pathways. Therefore, i