Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice

Autor: William Britton, Chi-Hsiu Liu, Zhongjie Fu, Shuo Huang, Ann Hellström, Bertan Cakir, Saswata Talukdar, Ye Sun, Mark Puder, Steve S Cho, Lois E.H. Smith, Yohei Tomita

Publikováno v: Angiogenesis

To examine whether free fatty acid receptor 4 (FFAR4) activation can protect against choroidal neovascularization (CNV), which is a common cause of blindness, and to elucidate the mechanism underlying the inhibition, we used the mouse model of laser-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332a012d96fd0dc472cf30395342b0d6
https://doi.org/10.1007/s10456-020-09717-x

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Autor: Yohei Tomita, Ye Sun, Chuck T. Chen, William Britton, Xi He, Chi-Hsiu Liu, Zhongjie Fu, Shuo Huang, Steve S Cho, Jian Xing Ma, Jing Chen, Zhongxiao Wang

Publikováno v: Science Advances

Wnt signaling pathway suppresses vascular endothelium transcytosis in the BRB through activating MFSD2A.
Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss. We investigated the role of Wnt signaling in maintaining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9c7a5bd2a9903128935287736846cd
https://doi.org/10.1126/sciadv.aba7457

MicroRNAs in Vascular Eye Diseases

Autor: Chi-Hsiu Liu, William Britton, Shuo Huang, Jing Chen

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 2, p 649 (2020)
International Journal of Molecular Sciences

Since the discovery of the first microRNA (miRNA) decades ago, studies of miRNA biology have expanded in many biomedical research fields, including eye research. The critical roles of miRNAs in normal development and diseases have made miRNAs useful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6ed3ca2d0e73413f3cd122ff3aff63
https://www.mdpi.com/1422-0067/21/2/649

Targeting Neurovascular Interaction in Retinal Disorders

Autor: Ye Sun, David A. Antonetti, Zhongxiao Wang, Chi-Hsiu Liu, Timothy S. Kern, Ann Hellström, Yohei Tomita, William Britton, Steve S Cho, Lois E.H. Smith, Zhongjie Fu, Shuo Huang, Bertan Cakir

Publikováno v: International journal of molecular sciences, vol 21, iss 4
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1503 (2020)
International Journal of Molecular Sciences

The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b836dee46b888f74e5df8b05ac0f4ac
https://doi.org/10.3390/ijms21041503

Wire-Interwoven Nitinol Stent Outcome in the Superficial Femoral and Proximal Popliteal Arteries: Twelve-Month Results of the SUPERB Trial

Autor: Lawrence, Garcia, Michael R, Jaff, Christopher, Metzger, Gino, Sedillo, Ashish, Pershad, Frank, Zidar, Raghotham, Patlola, Robert G, Wilkins, Andrey, Espinoza, Ayman, Iskander, George S, Khammar, Yazan, Khatib, Robert, Beasley, Satyaprakash, Makam, Richard, Kovach, Suraj, Kamat, Luis R, Leon, William Britton, Eaves, Jeffrey J, Popma, Laura, Mauri, Dennis, Donohoe, Carol C, Base, Kenneth, Rosenfield

Publikováno v: Circulation. Cardiovascular interventions. 8(5)

Background— Stent-based therapy in the superficial femoral and popliteal arteries in patients with peripheral artery disease i s compromised by restenosis and risk of stent fracture or distortion. A novel self-expanding nitinol stent was developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485db238dd2173aeefb690a7099dbe2f
https://pubmed.ncbi.nlm.nih.gov/26019141