Zobrazeno 1 - 10
of 203
pro vyhledávání: '"William Borkowsky"'
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
During the COVID-19 pandemic, children have had markedly different clinical presentations and outcomes compared to adults. In the acute phase of infection, younger children are relatively spared the severe consequences reported in adults. Yet, they a
Externí odkaz:
https://doaj.org/article/d2c3078978124ae1b51daed1ab66efc1
Autor:
Bret McCarty, Mussa Mwamzuka, Fatma Marshed, Matthew Generoso, Patricia Alvarez, Tiina Ilmet, Adam Kravietz, Aabid Ahmed, William Borkowsky, Derya Unutmaz, Alka Khaitan
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundT follicular helper (Tfh) cells are crucial for B cell differentiation and antigen-specific antibody production. Dysregulation of Tfh-mediated B cell help weakens B cell responses in HIV infection. Moreover, Tfh cells in the lymph node and
Externí odkaz:
https://doaj.org/article/aa3a2a5ce1b045bd82beef10213a5d6c
Autor:
Patricia Alvarez, Mussa Mwamzuka, Fatma Marshed, Adam Kravietz, Tiina Ilmet, Aabid Ahmed, William Borkowsky, Alka Khaitan
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190332 (2017)
BACKGROUND:HIV disease progresses more rapidly in children than adults with mortality rates exceeding 50% by 2 years of age without antiretroviral therapy (ART) in sub-Saharan Africa. Recent World Health Organization (WHO) guidelines recommend univer
Externí odkaz:
https://doaj.org/article/c524139e621748b3b32906e774545c7c
Autor:
Charlotte V Hobbs, Erin E Gabriel, Portia Kamthunzi, Gerald Tegha, Jean Tauzie, Elizabeth Petzold, Linda Barlow-Mosha, Benjamin H Chi, Yonghua Li, Tiina Ilmet, Brian Kirmse, Jillian Neal, Sunil Parikh, Nagamah Deygoo, Patrick Jean Philippe, Lynne Mofenson, William Prescott, Jingyang Chen, Philippa Musoke, Paul Palumbo, Patrick E Duffy, William Borkowsky, P1068s Study Team
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0165140 (2016)
BackgroundHIV and malaria geographically overlap. HIV protease inhibitors kill malaria parasites in vitro and in vivo, but further evaluation in clinical studies is needed.MethodsThirty-one children from Malawi aged 4-62 months were followed every 3
Externí odkaz:
https://doaj.org/article/9be34cfbe7584fb29c4482637349c2b8
Autor:
Alka Khaitan, Max Kilberg, Adam Kravietz, Tiina Ilmet, Cihan Tastan, Mussa Mwamzuka, Fatma Marshed, Mengling Liu, Aabid Ahmed, William Borkowsky, Derya Unutmaz
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161786 (2016)
Mucosal-associated invariant T cells (MAIT) are innate T cells restricted by major histocompatibility related molecule 1 (MR1) presenting riboflavin metabolite ligands derived from microbes. Specificity to riboflavin metabolites confers MAIT cells a
Externí odkaz:
https://doaj.org/article/4e154a96b93548d2aa3ff93ab6bae6cf
Autor:
Charlotte V Hobbs, Saurabh Dixit, Scott R Penzak, Tejram Sahu, Sachy Orr-Gonzalez, Lynn Lambert, Katie Zeleski, Jingyang Chen, Jillian Neal, William Borkowsky, Yimin Wu, Patrick E Duffy
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115506 (2014)
Plasmodium vivax malaria causes significant morbidity and mortality worldwide, and only one drug is in clinical use that can kill the hypnozoites that cause P. vivax relapses. HIV and P. vivax malaria geographically overlap in many areas of the world
Externí odkaz:
https://doaj.org/article/48ba693b91e1481ca63e8d467bb740a9
Autor:
Charlotte V Hobbs, Jillian Neal, Solomon Conteh, Liam Donnelly, Jingyang Chen, Kennan Marsh, Lynn Lambert, Sachy Orr-Gonzalez, Jessica Hinderer, Sara Healy, William Borkowsky, Scott R Penzak, Sumana Chakravarty, Stephen L Hoffman, Patrick E Duffy
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e100138 (2014)
We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relev
Externí odkaz:
https://doaj.org/article/353182e7d7cc4458a8f133409bc2339a
Autor:
Michael D Weiden, Satomi Hoshino, David N Levy, Yonghua Li, Rajnish Kumar, Sean A Burke, Rodney Dawson, Catarina E Hioe, William Borkowsky, William N Rom, Yoshihiko Hoshino
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108476 (2014)
While exploring the effects of aerosol IFN-γ treatment in HIV-1/tuberculosis co-infected patients, we observed A to G mutations in HIV-1 envelope sequences derived from bronchoalveolar lavage (BAL) of aerosol IFN-γ-treated patients and induction of
Externí odkaz:
https://doaj.org/article/4fb004f7ba614f2fae400c761c402fce
Autor:
Brian, Kirmse, Charlotte, Hobbs, Lisa, Aaron, Grace, Montepiedra, Marshall, Summar, Paige L, Williams, Caitlin J, Smith, Russell, Van Dyke, Chunli, Yu, Kelli K, Ryckman, William, Borkowsky, Anai, Cuadra
Publikováno v:
The Pediatric infectious disease journal. 41(8)
Mitochondrial toxicity resulting in myopathy and lactic acidosis has been described in antiretroviral (ARV)-exposed patients. We hypothesized that myopathy in HIV-infected, ARV-treated children would be associated with metabolic (acylcarnitines) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f8eb9e8790ad6104ecd890b1a277e7
https://pubmed.ncbi.nlm.nih.gov/35622436
https://pubmed.ncbi.nlm.nih.gov/35622436
Autor:
Tatiana Voza, William Borkowsky, Jillian Neal, Jean Langhorne, Solomon Conteh, Patrick E. Duffy, Charlotte V. Hobbs, Tejram Sahu
Publikováno v:
The American Journal of Tropical Medicine and Hygiene
HIV and malaria geographically overlap. Trimethoprim–sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a90929e65df96525214185c27e0c632
http://europepmc.org/articles/PMC7866335
http://europepmc.org/articles/PMC7866335