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pro vyhledávání: '"William Bialek"'
Autor:
William Bialek
Publikováno v:
SciPost Physics Lecture Notes, p 84 (2024)
Theoretical physicists have been fascinated by the phenomena of life for more than a century. As we engage with more realistic descriptions of living systems, however, things get complicated. After reviewing different reactions to this complexity, I
Externí odkaz:
https://doaj.org/article/50431d0cd6e048efa777c23a09934de7
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 1, p e1003408 (2014)
Maximum entropy models are the least structured probability distributions that exactly reproduce a chosen set of statistics measured in an interacting network. Here we use this principle to construct probabilistic models which describe the correlated
Externí odkaz:
https://doaj.org/article/4fcc5451a95f4710bbe8a0154b12ba8c
Autor:
Kanaka Rajan, William Bialek
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e71959 (2013)
The concept of feature selectivity in sensory signal processing can be formalized as dimensionality reduction: in a stimulus space of very high dimensions, neurons respond only to variations within some smaller, relevant subspace. But if neural respo
Externí odkaz:
https://doaj.org/article/e234e62eb0064ff0b56fb70bd306a6e7
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13914 (2010)
Organisms move through the world by changing their shape, and here we explore the mapping from shape space to movements in the nematode Caenorhabditis elegans as it crawls on an agar plate. We characterize the statistics of the trajectories through t
Externí odkaz:
https://doaj.org/article/319d751b7bb84e43979564dc71acce68
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2774 (2008)
Gene expression levels fluctuate even under constant external conditions. Much emphasis has usually been placed on the components of this noise that are due to randomness in transcription and translation. Here we focus on the role of noise associated
Externí odkaz:
https://doaj.org/article/29c389296e704f1db9154d853aa54e2c
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 4, p e1000028 (2008)
A major challenge in analyzing animal behavior is to discover some underlying simplicity in complex motor actions. Here, we show that the space of shapes adopted by the nematode Caenorhabditis elegans is low dimensional, with just four dimensions acc
Externí odkaz:
https://doaj.org/article/70faf61652e6476a97e09c672ec5a81e
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 3, p e1000025 (2008)
Sensory information about the outside world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant
Externí odkaz:
https://doaj.org/article/8158acb37fd24dd9bbeb6d8dfb853c2b
Autor:
Tatyana Sharpee, William Bialek
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e646 (2007)
We consider here how to separate multidimensional signals into two categories, such that the binary decision transmits the maximum possible information about those signals. Our motivation comes from the nervous system, where neurons process multidime
Externí odkaz:
https://doaj.org/article/aba5574ea78148058cdd22579ab2383d
Autor:
William Bialek
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(18)
SignificanceHow do we characterize animal behavior? Psychophysics started with human behavior in the laboratory, and focused on simple contexts, such as the decision among just a few alternative actions in response to sensory inputs. In contrast, eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa8b42df5cafd0ec2e13e9bac534016
https://pubmed.ncbi.nlm.nih.gov/36264834
https://pubmed.ncbi.nlm.nih.gov/36264834
Living systems are fundamentally irreversible, breaking detailed balance and establishing an arrow of time. But how does the evident arrow of time for a whole system arise from the interactions among its multiple elements? We show that the local evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7f1083d9dd457281e1f388fbd6e9f9
http://arxiv.org/abs/2203.01916
http://arxiv.org/abs/2203.01916
