Zobrazeno 1 - 6
of 6
pro vyhledávání: '"William B. Peeples"'
Publikováno v:
Nat Rev Mol Cell Biol
Biomolecular condensates are found throughout eukaryotic cells, in the nucleus, cytoplasm and on various membranes. They are also found across the biological spectrum, organizing molecules that act in processes ranging from RNA metabolism to signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2361e03f5277cd25c83f0b198f44a367
https://doi.org/10.1038/s41580-020-00303-z
https://doi.org/10.1038/s41580-020-00303-z
Autor:
William B. Peeples, Michael K. Rosen
Publikováno v:
Nature chemical biology. 17(6)
Biomolecular condensates concentrate macromolecules into discrete cellular foci without an encapsulating membrane. Condensates are often presumed to increase enzymatic reaction rates through increased concentrations of enzymes and substrates (mass ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39af990ca9de4088e4d2a60bf8e01097
https://pubmed.ncbi.nlm.nih.gov/34035520
https://pubmed.ncbi.nlm.nih.gov/34035520
Autor:
Daniel J. Saltzberg, Seung Joong Kim, William B. Peeples, Rustam Ali, Michael M. Soniat, Jenny Jiou, Yuan Lin, Andrej Sali, Nicolas L. Fawzi, Michael K. Rosen, Yuh Min Chook, Ho Yee Joyce Fung, Takuya Yoshizawa, Rudolf Oldenbourg, Jordan M. Baumhardt, Kathleen A. Burke
Publikováno v:
Cell, vol 173, iss 3
Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37b68163c846ed834bc6d8d66f139be
https://escholarship.org/uc/item/721888cp
https://escholarship.org/uc/item/721888cp
Autor:
Richard M. Walsh, Phillip G. Gross, William B. Peeples, Zachary A. Wood, Joseph E. Sanchez, Russell W. Goetze
Publikováno v:
Biochemistry. 54:3360-3369
Ketopantoate reductase (KPR) catalyzes the NADPH-dependent production of pantoate, an essential precursor in the biosynthesis of coenzyme A. Previous structural studies have been limited to Escherichia coli KPR, a monomeric enzyme that follows a sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69336f4679bfed0f35d7404cd846f756
https://doi.org/10.1021/acs.biochem.5b00174
https://doi.org/10.1021/acs.biochem.5b00174
Autor:
Jae-Min Lim, Zachary A. Wood, Richard M. Walsh, William B. Peeples, Lance Wells, Samuel J. Polizzi
Publikováno v:
Biochemistry. 51:8844-8855
Proteoglycans act as receptors for growth factors and are essential for cell proliferation, migration and adhesion.1–3 Disrupting proteoglycan biosynthesis can attenuate tumor growth and progression; thus controlling proteoglycan biosynthesis is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0f5ded54792ff136bee7b55246c4cd
https://doi.org/10.1021/bi301135b
https://doi.org/10.1021/bi301135b
Autor:
Roy Parker, William B. Peeples, Michael K. Rosen, Salman F. Banani, Yuan Lin, Allyson M. Rice, Saumya Jain
Publikováno v:
Cell. 166(3)
Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-separated liquids organized by multivalent interactions among proteins and RNA molecules. Although many components of various cellular bodies are known, general prin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012927da153ef8d280d652aede7dfa50
https://pubmed.ncbi.nlm.nih.gov/27374333
https://pubmed.ncbi.nlm.nih.gov/27374333