Zobrazeno 1 - 10
of 73
pro vyhledávání: '"William B. Mair"'
Autor:
Carlos A. Vergani-Junior, Raíssa De P. Moro, Silas Pinto, Evandro A. De-Souza, Henrique Camara, Deisi L. Braga, Guilherme Tonon-da-Silva, Thiago L. Knittel, Gabriel P. Ruiz, Raissa G. Ludwig, Katlin B. Massirer, William B. Mair, Marcelo A. Mori
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investiga
Externí odkaz:
https://doaj.org/article/3b0b37fbeb1a4553a647cd8257d8d1b5
Autor:
Klement Stojanovski, Ioana Gheorghe, Peter Lenart, Anne Lanjuin, William B. Mair, Benjamin D. Towbin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Even slight imbalance between the growth rate of different organs can accumulate to a large deviation from their appropriate size during development. Here, we use live imaging of the pharynx of C. elegans to ask if and how organ size scaling
Externí odkaz:
https://doaj.org/article/e6717014b02749d18f8741ca8020ab56
Autor:
Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.
Externí odkaz:
https://doaj.org/article/0b2d369bb38048e0accd70b4ceb4ae16
Autor:
Carlos G. Silva-García, Anne Lanjuin, Caroline Heintz, Sneha Dutta, Nicole M. Clark, William B. Mair
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2195-2198 (2019)
We have generated a single-copy knock-in loci for defined gene expression (SKI LODGE) system to insert any DNA by CRISPR/Cas9 at defined safe harbors in the Caenorhabditis elegans genome. Utilizing a single crRNA guide, which also acts as a Co-CRISPR
Externí odkaz:
https://doaj.org/article/01b6160a30a14edd9b392a8265bba243
Autor:
William B. Mair
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 86-87 (2020)
I helped organized an online seminar series for 1500 people with no planning. Here are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future.
Externí odkaz:
https://doaj.org/article/0030dce3a5f0463fbc031ec9f1febe29
Autor:
Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, Matthew S. Gill
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1695-1705 (2016)
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a library of bioactive l
Externí odkaz:
https://doaj.org/article/bcf733c1a23e4a328fb0ad6cb05baf2a
Autor:
Katharina Papsdorf, Jason W. Miklas, Amir Hosseini, Matias Cabruja, Christopher S. Morrow, Marzia Savini, Yong Yu, Carlos G. Silva-García, Nicole R. Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J. Dixon, Michael P. Snyder, Meng C. Wang, William B. Mair, Anne Brunet
Publikováno v:
Nature Cell Biology. 25:672-684
Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an organelle network involving lipid droplets and peroxisomes is critical for
Autor:
Marzia Savini, Andrew Folick, Yi-Tang Lee, Feng Jin, André Cuevas, Matthew C. Tillman, Jonathon D. Duffy, Qian Zhao, Isaiah A. Neve, Pei-Wen Hu, Yong Yu, Qinghao Zhang, Youqiong Ye, William B. Mair, Jin Wang, Leng Han, Eric A. Ortlund, Meng C. Wang
Publikováno v:
Nature cell biology, vol 24, iss 6
Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in ageing-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively co
Autor:
Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G Silva-García, Heather J Weir, Chia-Lin Lee, Caroline C Escoubas, Emina Tabakovic, William B Mair
Publikováno v:
eLife, Vol 8 (2019)
Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that
Externí odkaz:
https://doaj.org/article/75f6972b9e4a42e6978e901cc13f3d20
Autor:
Laura E. Wester, Anne Lanjuin, Emanuel H.W. Bruckisch, Maria C. Perez-Matos, Peter G. Stine, Caroline Heintz, Martin S. Denzel, William B. Mair
Publikováno v:
Cell Rep Methods
Here, we introduce a single-copy knockin translating ribosome immunoprecipitation (SKI TRIP) toolkit, a collection of Caenorhabditis elegans strains engineered by CRISPR in which tissue-specific expression of FLAG-tagged ribosomal subunit protein RPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a426d2278e05a3c826cc19af3f87d
https://europepmc.org/articles/PMC10088236/
https://europepmc.org/articles/PMC10088236/