Zobrazeno 1 - 10
of 14
pro vyhledávání: '"William B. Mahony"'
Publikováno v:
Biochemical Pharmacology. 46:725-729
The mechanism of membrane permeation of several 2′,3′-dideoxynucleosides was investigated at 37° with human erythrocytes using an “inhibitor-stop” assay. Transport (per 5 μL cells) via the nucleoside and nucleobase carriers was assessed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21fd406bb30d3f05f761fffc617a826
https://doi.org/10.1016/0006-2952(93)90560-j
https://doi.org/10.1016/0006-2952(93)90560-j
Publikováno v:
Biochemical Pharmacology. 42:147-152
The mechanism of transport of desciclovir (DCV)--a structural analogue and prodrug of acyclovir (ACV) which provides an improved oral bioavailability of ACV--was investigated in human erythrocytes with a "papaverine-stop" assay. DCV influx was noncon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673684216682c063c653420b860a2c8e
https://doi.org/10.1016/0006-2952(91)90693-y
https://doi.org/10.1016/0006-2952(91)90693-y
Publikováno v:
Biochemical Pharmacology. 41:263-271
The membrane permeation of ganciclovir (DHPG)--a structural analogue of acyclovir (ACV) with activity against cytomegalovirus--was investigated in human erythrocytes at 37 degrees with an "inhibitor-stop" assay. DHPG influx was nonconcentrative, occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b022869de899ec16c288c9d3707accf
https://doi.org/10.1016/0006-2952(91)90485-n
https://doi.org/10.1016/0006-2952(91)90485-n
Publikováno v:
Biochemical pharmacology. 68(9)
Abacavir, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol, is a novel purine carbocyclic nucleoside analogue that has been approved by the FDA for the treatment of HIV (as Ziagen trade mark [abacavir sulfate]). Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51760126b6a29915ab4dc692c801362
https://pubmed.ncbi.nlm.nih.gov/15450945
https://pubmed.ncbi.nlm.nih.gov/15450945
Autor:
Geoffrey J. Yuen, Nancy F. Thompson, H. Wayne Hutman, Yu Lou, Thurman Allsup, Victoria R. Otto, William B. Mahony
Publikováno v:
Journal of clinical pharmacology. 41(3)
A single-center, open-label, three-way crossover study was conducted in 24 healthy subjects to assess (1) the bioequivalence of a combined abacavir 300 mg/lamivudine 150 mg/zidovudine 300 mg (A/L/Z) combination tablet relative to the separate brand-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de2ddd065d2906fc3cda6b65ebbe8ea
https://pubmed.ncbi.nlm.nih.gov/11269568
https://pubmed.ncbi.nlm.nih.gov/11269568
Publikováno v:
Biochemical pharmacology. 46(3)
The transport of 5-fluorouracil (5-FU) and uracil into human erythrocytes has been investigated under initial velocity conditions with an "inhibitor-stop" assay using a cold papaverine solution to terminate influx. At 37 degrees and pH 7.3, 5-FU infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbafca3cf87711247b4628a1b9ea53c
https://pubmed.ncbi.nlm.nih.gov/8347174
https://pubmed.ncbi.nlm.nih.gov/8347174
Publikováno v:
Journal of Biological Chemistry. 262:5748-5754
The demonstrated in vitro and in vivo activity of 3′-azido-3′-deoxythymidine (N3dThd) against the infectivity and the cytopathic effect of human immunodeficiency virus has prompted an investigation of the mechanism by which this nucleoside analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b4f6611e4a92c9d3abeff395db837e
https://doi.org/10.1016/s0021-9258(18)45638-4
https://doi.org/10.1016/s0021-9258(18)45638-4
Publikováno v:
Journal of Biological Chemistry. 263:9276-9284
A novel "inhibitor-stop" method for the determination of initial rates of purine nucleobase transport in human erythrocytes has been developed, based on the addition of seven assay volumes of cold 19 mM papaverine to terminate influx. In view of our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6dc2eaef216d6a51a105dcf1044f825
https://doi.org/10.1016/s0021-9258(19)76536-3
https://doi.org/10.1016/s0021-9258(19)76536-3
Autor:
Thomas P. Zimmerman, William B. Mahony
Publikováno v:
Analytical Biochemistry. 154:235-243
5-[125I]Iodo-2'-deoxyuridine (IdUrd) has been shown to serve as a permeant for the nucleoside transport system of human erythrocytes and to be matabolically inert in these cells. Linear initial velocities were obtained at 20 degrees C for 125IdUrd tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51e845e6272e6ea0a6b4867fe2bb05e
https://doi.org/10.1016/0003-2697(86)90521-x
https://doi.org/10.1016/0003-2697(86)90521-x
Publikováno v:
Journal of Biological Chemistry. 263:9285-9291
The mechanism of transport of the antiviral agent acyclovir (ACV) into human erythrocytes has been investigated. Initial velocities of ACV influx were determined with an "inhibitor-stop" assay that used papaverine to inhibit ACV influx rapidly and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee37a4ac8a19a905a1957c75e088cd9
https://doi.org/10.1016/s0021-9258(19)76537-5
https://doi.org/10.1016/s0021-9258(19)76537-5