Zobrazeno 1 - 10
of 480
pro vyhledávání: '"William B. Guggino"'
Autor:
Emily Anne Smith Bergbower, Inna Sabirzhanova, Clément Boinot, William B. Guggino, Liudmila Cebotaru
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 6, Pp 1267-1279 (2019)
Externí odkaz:
https://doaj.org/article/6ad549979b1249a096b4e70ac778cad6
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 3, Pp 1489-1499 (2018)
Background/Aims: Cystic fibrosis (CF) is a lethal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR). ΔF508, the most common mutation, is a misfolded protein that is retained in the endoplasmic reticulum and
Externí odkaz:
https://doaj.org/article/72a194b27d754f52b3001997eeaefa36
Autor:
Hua Wang, Liudmila Cebotaru, Ha Won Lee, QingFeng Yang, Bette S. Pollard, Harvey B. Pollard, William B. Guggino
Publikováno v:
Cellular Physiology and Biochemistry, Vol 40, Iss 5, Pp 1063-1078 (2016)
Background/Aims: Chronic lung infection in cystic fibrosis leads to an inflammatory response that persists because of the chronic presence of bacteria and ultimately leads to a catastrophic failure of lung function. Methods: We use a combination of b
Externí odkaz:
https://doaj.org/article/836c9d236ae2477199b1eaaa4be9ddd3
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 1, Pp 172-182 (2016)
Background/AIM: STIM1 is as an essential component in store operated Ca2+ entry. However give the paucity of information on the role of STIM1 in kidney, the aim was to study the function of STIM1 in the medulla of the kidney. Methods: we crossed a Ks
Externí odkaz:
https://doaj.org/article/13d8d3790cd8467a979489a356a8692a
Autor:
Carolina Monteiro de Lemos Barbosa, Jackson Souza-Menezes, Andressa Godoy Amaral, Luiz Fernando Onuchic, Liudmila Cebotaru, William B. Guggino, Marcelo M. Morales
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 1, Pp 28-39 (2016)
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of multiple, progressive, fluid-filled renal cysts that distort the renal parenchyma, leading to end-stage renal failure, mainly after the fifth deca
Externí odkaz:
https://doaj.org/article/5b552f79852d4094a2991e01ffea7dca
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 318:G120-G129
Clostridium difficile (CD) is a common pathogen that causes severe gastrointestinal inflammatory diarrhea in patients undergoing antibiotic therapy. Its virulence derives from two toxins, toxin CD, A and B (TcdA and TcdB) (Borriello et al. Rev Infect
Publikováno v:
Cell Calcium
Mutations in either of the polycystic kidney disease genes, PKD1 or PKD2, engender the growth of cysts, altering renal function. Cystic growth is supported by major changes in cellular metabolism, some of which involve the mitochondrion, a major stor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060905f80c36677231e998717fa5494a
https://europepmc.org/articles/PMC8840832/
https://europepmc.org/articles/PMC8840832/
Autor:
Daniele Rapino, Inna Sabirzhanova, Miquéias Lopes-Pacheco, Rahul Grover, William B Guggino, Liudmila Cebotaru
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119796 (2015)
Although, the most common Cystic Fibrosis mutation, ΔF508, in the cystic fibrosis transmembrane regulator. (CFTR), is located in nucleotide binding domain (NBD1), disease-causing mutations also occur in NBD2. To provide information on potential ther
Externí odkaz:
https://doaj.org/article/1bdf52ead2e6454183d9cd5473573926
Autor:
Maria Alice P. Rebelo, Vera Tostes, Nordeval C. Araújo, Sabrina V. Martini, Bruno F. Botelho, William B. Guggino, Marcelo M. Morales
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 77, Iss 1, Pp 95-101 (2005)
Thirty-five patients (23 males and 12 females), age 35 ± 13 years old, presenting either idiopathic calcium nephrolithiasis, nephrocalcinosis or mild renal failure with idiopathic calcium nephrolithiasis were selected for the analysis of low molecul
Externí odkaz:
https://doaj.org/article/7403c59e9458489dba4a70ceb2de53aa
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85183 (2014)
Cystic fibrosis is caused by more than 1000 mutations, the most common being the ΔF508 mutation. These mutations have been divided into five classes [1], with ΔF508 CFTR in class II. Here we have studied the class V mutation A455E. We report that t
Externí odkaz:
https://doaj.org/article/ea8e4a4bffb64c82bb41e23d3d769d91