Zobrazeno 1 - 10 of 180 pro vyhledávání: '"William B Weglicki"'
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Akademický článek
Mg-supplementation attenuated lipogenic and oxidative/nitrosative gene expression caused by Combination Antiretroviral Therapy (cART) in HIV-1-transgenic rats.
Autor: Lama ElZohary, William B Weglicki, Joanna J Chmielinska, Jay H Kramer, I Tong Mak
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210107 (2019)
We determined if HIV-1 expression in transgenic (HIV-1-Tg) rats enhanced hepatic genomic changes related to oxidative/nitrosative stress and lipogenesis during cART-treatment, and assessed effects of Mg-supplementation. A clinically used cART (atazan
Externí odkaz: https://doaj.org/article/d4892e25a4ee46c5a3e056cc11b787f5
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2
Deficiency in gp91Phox (NOX2) Protects against Oxidative Stress and Cardiac Dysfunction in Iron Overloaded Mice
Autor: Christopher F. Spurney, Micaela Iantorno, William B. Weglicki, I. Tong Mak, Joanna J. Chmielinska, Jay H. Kramer
Publikováno v: Hearts. 1:117-125
The role of NADPH oxidase subunit, gp91phox (NOX2) in development of oxidative stress and cardiac dysfunction due to iron (Fe)-overload was assessed. Control (C57BL/6J) and gp91phox knockout (KO) mice were treated for up to 8 weeks with Fe (2.5 mg/g/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6ccd28c0df315b6457326a652ba67f7
https://doi.org/10.3390/hearts1020012
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3
Experimental Hypomagnesemia Induces Neurogenic Inflammation and Cardiac Dysfunction
Autor: Christopher F. Spurney, Jay H. Kramer, I. Tong Mak, William B. Weglicki, Terry M. Phillips, Joanna J. Chmielinska
Publikováno v: Hearts
Volume 1
Issue 2
Pages 11-116
Hypomagnesemia occurs clinically as a result of restricted dietary intake, Mg-wasting drug therapies, chronic disease status and may be a risk factor in patients with cardiovascular disorders. Dietary restriction of magnesium (Mg deficiency) in anima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcb26561286e64303587790ae57207a
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4
Hypomagnesemia in diabetes patients: comparison of serum and intracellular measurement of responses to magnesium supplementation and its role in inflammation
Autor: Nada Alam-Eldin, William B. Weglicki, I.T. Mak, Burton Silver, N. Zghoul
Publikováno v: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Nadia Zghoul,1 Nada Alam-Eldin,1 Ivan Tong Mak,2 Burton Silver,3 William B Weglicki2 1Clinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait, Kuwait; 2Department of Biochemistry and Molecular Medicine, George Washington University, Washing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c086d7713e5274a3eb0e1717db34eae
http://europepmc.org/articles/PMC6080849
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5
Substance P receptor blocker, aprepitant, inhibited cutaneous and other neurogenic inflammation side effects of the EGFR1-TKI, erlotinib
Autor: Joanna J. Chmielinska, I-Tong Mak, Christopher F. Spurney, William B. Weglicki, Jay H. Kramer
Publikováno v: Molecular and cellular biochemistry. 465(1-2)
Cutaneous changes like rash and hair loss, as well as other neurogenic inflammation side effects, occur frequently during anticancer treatment with the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), erlotinib. These adverse ev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea9efe7dacfde9d59e3db8bf239fac3
https://pubmed.ncbi.nlm.nih.gov/31853800
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7
Combination ART-Induced Oxidative/Nitrosative Stress, Neurogenic Inflammation and Cardiac Dysfunction in HIV-1 Transgenic (Tg) Rats: Protection by Mg
Autor: Joanna J. Chmielinska, Jay H. Kramer, William B. Weglicki, Christopher F. Spurney, I. Tong Mak
Publikováno v: International Journal of Molecular Sciences
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2409 (2018)
Chronic effects of a combination antiretroviral therapy (cART = tenofovir/emtricitatine + atazanavir/ritonavir) on systemic and cardiac oxidative stress/injury in HIV-1 transgenic (Tg) rats and protection by Mg-supplementation were assessed. cART (lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3727393d413f83fa6aad6c600751f3d
https://pubmed.ncbi.nlm.nih.gov/30111743
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9
Mg-Supplementation Protects Against Oxidative Stress and Cardiac Dysfunction in Chronic Highly Active Antiretroviral Therapy–Treated Rats
Autor: Jay H. Kramer, I.T. Mak, William B. Weglicki, Joanna J. Chmielinska, Chris Spurney
Highly active antiretroviral therapy (HAART) agents, azidothymidine (AZT), ritonavir (RTV), and efavirenz (EFV), were assessed in vivo for oxidative stress, cardiac injury, and dysfunction in rats, and dietary Mg-supplementation (Mg-Sup sixfold highe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f1c060c0eb8f2dc5112afa70e7c4582
https://doi.org/10.1016/b978-0-12-809853-0.00016-x
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10
EGFR-TKI, Erlotinib, Causes Hypomagnesemia, Oxidative Stress, and Cardiac Dysfunction
Autor: William B. Weglicki, I. Tong Mak, Christopher F. Spurney, Joanna J. Chmielinska, Jay H. Kramer
Publikováno v: Journal of Cardiovascular Pharmacology. 65:54-61
To determine whether the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib may cause hypomagnesemia, inflammation, and cardiac stress, erlotinib was administered to rats (10 mg · kg(-1)· d(-1)) for 9 weeks. Plasma magnesium decr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdaa878e19b80049e9b9964435dd766
https://doi.org/10.1097/fjc.0000000000000163
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