Zobrazeno 1 - 10
of 60
pro vyhledávání: '"William B Lott"'
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202079 (2018)
A mathematical model was developed for mesenchymal stromal cell (MSC) growth in a packed bed bioreactor that improves oxygen availability by allowing oxygen diffusion through a gas-permeable wall. The governing equations for oxygen, glucose and lacta
Externí odkaz:
https://doaj.org/article/78537c0c3afd4673a095740902b93739
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0122250 (2015)
We and others have published on the rapid manufacture of micropellet tissues, typically formed from 100-500 cells each. The micropellet geometry enhances cellular biological properties, and in many cases the micropellets can subsequently be utilized
Externí odkaz:
https://doaj.org/article/fca69fa74cdf4cd4a8a6fd7dd4ed4e91
Autor:
Md Abu Choudhury, William B Lott, Shahera Banu, Anthony Youzhi Cheng, Yik-Ying Teo, Rick Twee-Hee Ong, John Aaskov
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142473 (2015)
Dengue virus (DENV) populations are characteristically highly diverse. Regular lineage extinction and replacement is an important dynamic DENV feature, and most DENV lineage turnover events are associated with increased incidence of disease. The role
Externí odkaz:
https://doaj.org/article/e95bc840c3cb4330a5e9415381cec0e9
Autor:
Michael J Osiecki, Thomas D Michl, Betul Kul Babur, Mahboubeh Kabiri, Kerry Atkinson, William B Lott, Hans J Griesser, Michael R Doran
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144941 (2015)
Large numbers of Mesenchymal stem/stromal cells (MSCs) are required for clinical relevant doses to treat a number of diseases. To economically manufacture these MSCs, an automated bioreactor system will be required. Herein we describe the development
Externí odkaz:
https://doaj.org/article/e57d14b843ff4ac0aa9dc044fdbec3af
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107264 (2014)
Genetically diverse RNA viruses like dengue viruses (DENVs) segregate into multiple, genetically distinct, lineages that temporally arise and disappear on a regular basis. Lineage turnover may occur through multiple processes such as, stochastic or d
Externí odkaz:
https://doaj.org/article/de807441acfc40d4987d61beccf32c9b
Autor:
Betul Kul Babur, Parisa Ghanavi, Peter Levett, William B Lott, Travis Klein, Justin J Cooper-White, Ross Crawford, Michael R Doran
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58865 (2013)
Chondrocytes dedifferentiate during ex vivo expansion on 2-dimensional surfaces. Aggregation of the expanded cells into 3-dimensional pellets, in the presence of induction factors, facilitates their redifferentiation and restoration of the chondrogen
Externí odkaz:
https://doaj.org/article/d2778d6c8cde41188803d346bd7c5d5a
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24547 (2011)
DegP, a member of the HtrA family of proteins, conducts critical bacterial protein quality control by both chaperone and proteolysis activities. The regulatory mechanisms controlling these two distinct activities, however, are unknown. DegP activatio
Externí odkaz:
https://doaj.org/article/da4399153c4245da9364abf9162c3516
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18197 (2011)
Infectious cDNA clones of RNA viruses are important research tools, but flavivirus cDNA clones have proven difficult to assemble and propagate in bacteria. This has been attributed to genetic instability and/or host cell toxicity, however the mechani
Externí odkaz:
https://doaj.org/article/d848f82ff91a4397905674aa9467ee9a
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19447 (2011)
While much of the genetic variation in RNA viruses arises because of the error-prone nature of their RNA-dependent RNA polymerases, much larger changes may occur as a result of recombination. An extreme example of genetic change is found in defective
Externí odkaz:
https://doaj.org/article/21b9da125dfb4ca6b410e6bdddbb9f32
Autor:
Melissa E. Monterosso, Kathryn Futrega, William B. Lott, Ian Vela, Elizabeth D. Williams, Michael R. Doran
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Prostate cancer (PCa) patient-derived xenografts (PDXs) are commonly propagated by serial transplantation of “pieces” of tumour in mice, but the cellular composition of pieces is not standardised. Herein, we optimised a microwell platfor
Externí odkaz:
https://doaj.org/article/2f5eb33aec0547329c75ee64f3601dbc