Zobrazeno 1 - 10
of 123
pro vyhledávání: '"William B Klimstra"'
Autor:
Douglas S Reed, Anita K McElroy, Dominique J Barbeau, Cynthia M McMillen, Natasha L Tilston-Lunel, Shamkumar Nambulli, Emily Cottle, Theron C Gilliland, Hasala Rannulu, Jeneveve Lundy, Emily L Olsen, Katherine J O'Malley, Mengying Xia, Amy L Hartman, Thomas C Luke, Kristi Egland, Christoph Bausch, Hua Wu, Eddie J Sullivan, William B Klimstra, W Paul Duprex
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0290909 (2024)
Since SARS-CoV-2 emerged in late 2019, it spread from China to the rest of the world. An initial concern was the potential for vaccine- or antibody-dependent enhancement (ADE) of disease as had been reported with other coronaviruses. To evaluate this
Externí odkaz:
https://doaj.org/article/e111baf91dfb4fc09c7205841d90cc09
Autor:
Henry Ma, Joseph R Albe, Theron Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Noah Salama, Katherine J O'Malley, Ivona Pandrea, Tobias Teichert, Stacey Barrick, William B Klimstra, Amy L Hartman, Douglas S Reed
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1009946 (2022)
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring pa
Externí odkaz:
https://doaj.org/article/a9ae6f80485742ccbbc0ae30019f063d
Autor:
Joseph R Albe, Henry Ma, Theron H Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Katherine J O'Malley, Noah Salama, Aaron W Walters, Ivona Pandrea, Tobias Teichert, William B Klimstra, Douglas S Reed, Amy L Hartman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009308 (2021)
Aerosol exposure to eastern equine encephalitis virus (EEEV) can trigger a lethal viral encephalitis in cynomolgus macaques which resembles severe human disease. Biomarkers indicative of central nervous system (CNS) infection by the virus and lethal
Externí odkaz:
https://doaj.org/article/148107b18d2d4b4295040268973f0ef0
Autor:
Amy L Hartman, Sham Nambulli, Cynthia M McMillen, Alexander G White, Natasha Louise Tilston-Lunel, Joseph R Albe, Emily Cottle, Matthew D Dunn, L James Frye, Theron H Gilliland, Emily L Olsen, Katherine J O'Malley, Madeline M Schwarz, Jaime A Tomko, Reagan C Walker, Mengying Xia, Matthew S Hartman, Edwin Klein, Charles A Scanga, JoAnne L Flynn, William B Klimstra, Anita K McElroy, Douglas S Reed, W Paul Duprex
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008903 (2020)
Vaccines are urgently needed to combat the global coronavirus disease 2019 (COVID-19) pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) model is a critical step in the process. Infection of African green monkeys (A
Externí odkaz:
https://doaj.org/article/9af9b959abac4308b999b6e2d34961ea
Autor:
Henry Ma, Jeneveve D Lundy, Emily L Cottle, Katherine J O'Malley, Anita M Trichel, William B Klimstra, Amy L Hartman, Douglas S Reed, Tobias Teichert
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232381 (2020)
Alphaviruses such as Venezuelan equine encephalitis virus (VEEV) and Eastern equine encephalitis virus (EEEV) are arboviruses that can cause severe zoonotic disease in humans. Both VEEV and EEEV are highly infectious when aerosolized and can be used
Externí odkaz:
https://doaj.org/article/b5ecf1b03da445c3a3f1211a99c6fa94
Autor:
Derek W Trobaugh, Chengqun Sun, Nishank Bhalla, Christina L Gardner, Matthew D Dunn, William B Klimstra
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007867 (2019)
Eastern equine encephalitis virus (EEEV), a mosquito-borne RNA virus, is one of the most acutely virulent viruses endemic to the Americas, causing between 30% and 70% mortality in symptomatic human cases. A major factor in the virulence of EEEV is th
Externí odkaz:
https://doaj.org/article/d8899a9e015846fa931e6b83ecce4270
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007584 (2019)
Live attenuated vaccines (LAVs), if sufficiently safe, provide the most potent and durable anti-pathogen responses in vaccinees with single immunizations commonly yielding lifelong immunity. Historically, viral LAVs were derived by blind passage of v
Externí odkaz:
https://doaj.org/article/15628936e157463298e6f016f2dff81e
Autor:
Alan M Watson, Annika H Rose, Gregory A Gibson, Christina L Gardner, Chengqun Sun, Douglas S Reed, L K Metthew Lam, Claudette M St Croix, Peter L Strick, William B Klimstra, Simon C Watkins
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180486 (2017)
Whole-brain imaging is becoming a fundamental means of experimental insight; however, achieving subcellular resolution imagery in a reasonable time window has not been possible. We describe the first application of multicolor ribbon scanning confocal
Externí odkaz:
https://doaj.org/article/0e6afc151b5a45e0a619bd14bbc2f3f3
Autor:
Michael J Conway, Berlin Londono-Renteria, Andrea Troupin, Alan M Watson, William B Klimstra, Erol Fikrig, Tonya M Colpitts
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004941 (2016)
Aedes aegypti is the primary vector of several medically relevant arboviruses including dengue virus (DENV) types 1-4. Ae. aegypti transmits DENV by inoculating virus-infected saliva into host skin during probing and feeding. Ae. aegypti saliva conta
Externí odkaz:
https://doaj.org/article/578446c954934bc2af9050a87dd833f6
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005786 (2016)
A gold standard of antiviral vaccination has been the safe and effective live-attenuated 17D-based yellow fever virus (YFV) vaccines. Among more than 500 million vaccinees, only a handful of cases have been reported in which vaccinees developed a vir
Externí odkaz:
https://doaj.org/article/673e81f7346e4d449cae3e4bf2dbd3ea