Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William B Davey"'
Autor:
Michael Rowley, Ian Collins, Howard B. Broughton, William B. Davey, Raymond Baker, Frances Emms, Rosemarie Marwood, Shil Patel, Smita Patel, C. Ian Ragan, Stephen B. Freedman, Richard Ball, Paul D. Leeson
Publikováno v:
Journal of Medicinal Chemistry. 40:2374-2385
5-(4-Chlorophenyl)-3-(1-(4-chlorobenzyl)piperidin-4-yl)pyrazole (3) was identified from screening of the Merck sample collection as a human dopamine D4 (hD4) receptor ligand with moderate affinity (61 nM) and 4-fold selectivity over human D2 (hD2) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1edd60f700febd9c51288d528d277eb
https://doi.org/10.1021/jm970111h
https://doi.org/10.1021/jm970111h
Autor:
Stephen B. Freedman, Smita Patel, F. Emms, Shil Patel, C. I. Ragan, Ian Collins, Rosemarie Marwood, Howard B. Broughton, Richard G. Ball, Michael Rowley, Raymond Baker, Paul D. Leeson, William B Davey
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c9eb90da8f4c856d11aa2e4d21fb7f
https://doi.org/10.1002/chin.199746141
https://doi.org/10.1002/chin.199746141
Autor:
Ian Collins, John R. Atack, K Quirk, Bindi Sohal, Andrew Pike, Sally-Ann Thompson, Michael Rowley, Gerard R. Dawson, Richard G. Ball, José L. Castro, Christopher Moyes, William B Davey, Frances A. Bromidge, Keith A. Wafford, Nancy N. Tsou, Ruth M. McKernan
Publikováno v:
Journal of medicinal chemistry. 45(9)
A novel series of 3-heteroaryl-5,6-bis(aryl)-1-methyl-2-pyridones were developed with high affinity for the benzodiazepine (BZ) binding site of human gamma-aminobutyric acid (GABA(A)) receptor ion channels, low binding selectivity for alpha 2- and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c69ddefbd8dce4e72545c5998e30f50
https://pubmed.ncbi.nlm.nih.gov/11960500
https://pubmed.ncbi.nlm.nih.gov/11960500
Autor:
Ian Collins, Ruth M. McKernan, Sally-Anne Thompson, K Quirk, Michael Rowley, William B Davey, Keith A. Wafford, Frances A. Bromidge
Publikováno v:
ChemInform. 31
A new class of N-(indol-3-ylglyoxylyl)piperidines are high affinity agonists at the benzodiazepine binding site of human GABA-A receptor ion-channels, with modest selectivity for receptors containing the α1 subunit over α2 and α3. All three recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d8dff2280f3c191a82ed47c997a8a47
https://doi.org/10.1002/chin.200039131
https://doi.org/10.1002/chin.200039131
Autor:
Michael Rowley, Ruth M. McKernan, Ian Collins, Frances A. Bromidge, Keith A. Wafford, Sally-Anne Thompson, William B Davey, K Quirk
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(12)
A new class of N-(indol-3-ylglyoxylyl)piperidines are high affinity agonists at the benzodiazepine binding site of human GABA-A receptor ion-channels, with modest selectivity for receptors containing the alpha1 subunit over alpha2 and alpha3. All thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd68526598cc3140f47891ff90406601
https://pubmed.ncbi.nlm.nih.gov/10890169
https://pubmed.ncbi.nlm.nih.gov/10890169
Autor:
Ian Collins, Michael Rowley, Alan E. Fletcher, William B Davey, Ann L Scott, Rosemarie Marwood, Shil Patel, F. Emms, Paul D. Leeson, Theodore P. Broten, Ian C. Ragan, Smita Patel
Publikováno v:
Bioorganicmedicinal chemistry. 6(6)
3-(4-Piperidinyl)-5-arylpyrazoles, such as 1, were selective for the cloned human dopamine D4 receptor (hD4), but also showed affinity at voltage sensitive calcium, sodium and potassium ion channels. A combination of substituent changes to reduce the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f7c49406a6edd03c6b3f84a8b9eaf6
https://pubmed.ncbi.nlm.nih.gov/9681140
https://pubmed.ncbi.nlm.nih.gov/9681140
Autor:
Craig Armstrong
Newcastle was a key cog in the national war effort despite its northerly location, located on the key East Coast it played a significant military and civil role in the war. Newcastle is situated on the strategically important River Tyne and was well
