Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William Arbuckle"'
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 10, Pp m1232-m1232 (2009)
The asymmetric unit of the anhydrous title compound, 2Na+·C4H4O62−, contains two sodium cations and one tartrate anion. Each sodium ion is six coordinate, with bonding to six O atoms from both the carboxylate and hydroxyl groups of the anion. A th
Externí odkaz:
https://doaj.org/article/41abfcbceeec4e87a9362b12f88089c3
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 8, Pp o1768-o1769 (2009)
The asymmetric unit of the title compound [systematic name: (R,R)-2,4-bis(4-hydroxyphenyl)-N,N′-dimethyl-3-oxapentane-1,5-diammonium bis(hydrogen sulfate)], C18H26N2O32+·2HSO4−, contains one half-cation and one hydrogen sulfate anion. The cation
Externí odkaz:
https://doaj.org/article/2170ae0848584e60970c95fa9d921727
Autor:
Lindsay Gibson, David R. Barn, Mark Craighead, William Arbuckle, Rachel Milne, Hazel Sloan, Chris Claxton, Susan Elizabeth Napier, Matilda Bingham, Grant Wishart, Cliona P MacSweeney, Richard Goodwin, N.G. Irving, Zara Turnbull, Kirsteen Buchanan, Jeremy Presland, Angus R. Brown, Alan Byford, Chris Mort, Fiona Thomson, Susan Goutcher, James R. Baker, Lee Fielding, Trevor Young
The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc0d41bbebfcb82e69bfeb8a58ca72c
https://doi.org/10.1016/j.bmcl.2011.02.096
https://doi.org/10.1016/j.bmcl.2011.02.096
Publikováno v:
Crystal Growth & Design. 11:1821-1834
A data set of systematically related solid-state structures of pharmaceutical relevance has been created and used to investigate structural impact on physical properties in 20 pairs of enantiopure and racemic methylephedrinium salts. The structures a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7cf2e2cc12e4bcb24148a73ee22d645
https://doi.org/10.1021/cg200030s
https://doi.org/10.1021/cg200030s
Autor:
Brian Montgomery, Jeremy Presland, Rachel Milne, Grant Wishart, David R. Barn, Susan Elizabeth Napier, Mark Craighead, Hazel Sloan, Susan Goutcher, Matilda Bingham, Zara Turnbull, Amanda J. Lyons, Richard Goodwin, Kirsteen Buchanan, William Arbuckle, Angus R. Brown, Michael Kiczun, James R. Baker
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(15)
The previously described lead compound 5 is a potent and selective V(1A) antagonist with affinity at both the rat and human receptor, but displays poor oral bioavailability and moderate clearance. We report herein the successful optimisation of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e679945846d1ce55e781e8d8ca24e90
https://pubmed.ncbi.nlm.nih.gov/21700453
https://pubmed.ncbi.nlm.nih.gov/21700453
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 10, Pp m1232-m1232 (2009)
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E: Structure Reports
The asymmetric unit of the anhydrous title compound, 2Na+·C4H4O62−, contains two sodium cations and one tartrate anion. Each sodium ion is six coordinate, with bonding to six O atoms from both the carboxylate and hydroxyl groups of the anion. A th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6480f87d3b72c2a1cc3a2e1fca9289
http://scripts.iucr.org/cgi-bin/paper?S1600536809037155
http://scripts.iucr.org/cgi-bin/paper?S1600536809037155
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 8, Pp o1768-o1769 (2009)
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E: Structure Reports
The asymmetric unit of the title compound [systematic name: (R, R)-2,4-bis(4-hydroxyphenyl)-N,N'-dimethyl-3-oxapentane-1,5- diammonium bis(hydrogen sulfate)], C18H26N2O32+center dot-2HSO(4)(-), contains one half-cation and one hydrogen sulfate anion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248a5d3de0f0eba47c21ddcd6036169
https://doi.org/10.1107/s1600536809025288
https://doi.org/10.1107/s1600536809025288
Autor:
Alexander Scott, William Arbuckle
Publikováno v:
J. Chem. Soc., Trans.. 79:302-303
n/a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21707c2211422ac40545438dfe3771d
https://doi.org/10.1039/ct9017900302
https://doi.org/10.1039/ct9017900302