Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William Alexander Denny"'
Autor:
Peter Jaein Choi, Petr Tomek, Moana Tercel, Jóhannes Reynisson, Thomas In Hyeup Park, Elizabeth Alexandra Cooper, William Alexander Denny, Jiney Jose, Euphemia Leung
Publikováno v:
Molecules, Vol 27, Iss 3, p 880 (2022)
The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in
Externí odkaz:
https://doaj.org/article/e671aec5e09f4bc3b420e8a46419a8b3
Autor:
Leslie W. Deady, William Alexander Denny, Anthony J. Kaye, Bruce Charles Baguley, Graeme J. Finlay
Publikováno v:
Journal of Medicinal Chemistry. 40:2040-2046
A series of tetracyclic quinoline- and quinoxalinecarboxamides were prepared, and their cytotoxicities were evaluated in a series of murine human tumor cell lines. Most of the quinoline derivatives were prepared by an adaptation of the Pfitzinger syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e13baf3fd69584eb3f711f4b346dd8
https://doi.org/10.1021/jm970044r
https://doi.org/10.1021/jm970044r
Publikováno v:
ChemInform. 25
A series of azaacridine (benzonaphthyridine) analogues of the drug N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide (DACA) (currently in clinical trial) were synthesized. These compounds showed DNA binding affinities similar to that of DACA, as dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80a50b7ba406bc785a63ec83ea5018a
https://doi.org/10.1002/chin.199427150
https://doi.org/10.1002/chin.199427150
Autor:
William Alexander Denny, Anthony J. Kaye, Leslie W. Deady, Graeme J. Finlay, Bruce Charles Baguley
Publikováno v:
ChemInform. 28
A series of tetracyclic quinoline- and quinoxalinecarboxamides were prepared, and their cytotoxicities were evaluated in a series of murine human tumor cell lines. Most of the quinoline derivatives were prepared by an adaptation of the Pfitzinger syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beec63dac8815532100cf0ed4b27a22d
https://doi.org/10.1002/chin.199741183
https://doi.org/10.1002/chin.199741183
Autor:
D. Snowdon, R. K. Ralph, Simon L. Croft, Stanley J. Wojcik, Vanessa Yardley, A. Ransijn, William Alexander Denny, Swarna A. Gamage, D. P. Figgitt, J. Mauel
Publikováno v:
ChemInform. 28
Members of the class of 9-anilinoacridine topoisomerase II inhibitors bearing lipophilic electron-donating 1‘-anilino substituents are active against both the promastigote and amastigote forms of the parasite Leishmania major. A series of analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362bd3002cb481f59d89b75e1e83bcba
https://doi.org/10.1002/chin.199748177
https://doi.org/10.1002/chin.199748177
Autor:
William Alexander Denny, Leslie W. Deady, Bruce Charles Baguley, Xianyong Bu, Graeme J. Finlay
Publikováno v:
ChemInform. 32
A series of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidines bearing cationic side chains were prepared from aminoanthraquinones. The perimidines were prepared from 1-aminoanthraquinone by initial condensation with urea or dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0c335d4bd22be1a1db557ab6eb7aa2
https://doi.org/10.1002/chin.200138141
https://doi.org/10.1002/chin.200138141
Autor:
Leslie W. Deady, William Alexander Denny, Xianyong Bu, Graeme J. Finlay, Bruce Charles Baguley
Publikováno v:
Journal of medicinal chemistry. 44(12)
A series of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidines bearing cationic side chains were prepared from aminoanthraquinones. The perimidines were prepared from 1-aminoanthraquinone by initial condensation with urea or dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64472f5c4c8503327ceff3ec622fd4ff
https://pubmed.ncbi.nlm.nih.gov/11384245
https://pubmed.ncbi.nlm.nih.gov/11384245
Autor:
D. Snowdon, Stanley J. Wojcik, R. K. Ralph, J. Mauel, Swarna A. Gamage, D. P. Figgitt, A. Ransijn, William Alexander Denny, Vanessa Yardley, Simon L. Croft
Publikováno v:
Journal of medicinal chemistry. 40(16)
Members of the class of 9-anilinoacridine topoisomerase II inhibitors bearing lipophilic electron-donating 1'-anilino substituents are active against both the promastigote and amastigote forms of the parasite Leishmania major. A series of analogues o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708f3be8f2237cac2d08fbe37131306
https://pubmed.ncbi.nlm.nih.gov/9258370
https://pubmed.ncbi.nlm.nih.gov/9258370
Publikováno v:
Journal of medicinal chemistry. 37(5)
A series of azaacridine (benzonaphthyridine) analogues of the drug N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide (DACA) (currently in clinical trial) were synthesized. These compounds showed DNA binding affinities similar to that of DACA, as dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3a4754016541db7ea482ef611454c8
https://pubmed.ncbi.nlm.nih.gov/8126699
https://pubmed.ncbi.nlm.nih.gov/8126699
Publikováno v:
Molecular Aspects of Anticancer Drug-DNA Interactions ISBN: 9781349133321
We have previously (Denny et al., 1983) outlined the considerable importance of acridines in clinical medicine, dating from the early years of the twentieth century, primarily as antibacterial and antimalarial agents. We also noted the changing of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe0b913c0851891cc424101b8eb1b8d3
https://doi.org/10.1007/978-1-349-13330-7_7
https://doi.org/10.1007/978-1-349-13330-7_7
