Zobrazeno 1 - 10
of 36
pro vyhledávání: '"William A. Valente"'
Autor:
Grace X. Y. Zheng, Jessica M. Terry, Phillip Belgrader, Paul Ryvkin, Zachary W. Bent, Ryan Wilson, Solongo B. Ziraldo, Tobias D. Wheeler, Geoff P. McDermott, Junjie Zhu, Mark T. Gregory, Joe Shuga, Luz Montesclaros, Jason G. Underwood, Donald A. Masquelier, Stefanie Y. Nishimura, Michael Schnall-Levin, Paul W. Wyatt, Christopher M. Hindson, Rajiv Bharadwaj, Alexander Wong, Kevin D. Ness, Lan W. Beppu, H. Joachim Deeg, Christopher McFarland, Keith R. Loeb, William J. Valente, Nolan G. Ericson, Emily A. Stevens, Jerald P. Radich, Tarjei S. Mikkelsen, Benjamin J. Hindson, Jason H. Bielas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Single-cell gene expression analysis is challenging. This work describes a new droplet-based single cell RNA-seq platform capable of processing tens of thousands of cells across 8 independent samples in minutes, and demonstrates cellular subtypes and
Externí odkaz:
https://doaj.org/article/9c33171e807745c7908a1e1e9a3712e3
Autor:
Valentin Voillet, Trisha R. Berger, Kelly M. McKenna, Kelly G. Paulson, Wei Hong Tan, Kimberly S. Smythe, Daniel S. Hunter, William J. Valente, Stephanie Weaver, Jean S. Campbell, Teresa S. Kim, David R. Byrd, Jason H. Bielas, Robert H. Pierce, Aude G. Chapuis, Raphaël Gottardo, Anthony Rongvaux
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(3)
Despite recent therapeutic progress, advanced melanoma remains lethal for many patients. The composition of the immune tumor microenvironment (TME) has decisive impacts on therapy response and disease outcome, and high-dimensional analyses of patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d35e77fe78f95acfd6b197f050d244
https://pubmed.ncbi.nlm.nih.gov/35817516
https://pubmed.ncbi.nlm.nih.gov/35817516
Autor:
Aude G. Chapuis, Jean S. Campbell, Jason H. Bielas, Trisha R. Berger, Valentin Voillet, Teresa S. Kim, David R. Byrd, Kimberly S. Smythe, Stephanie Weaver, Kelly M. McKenna, Raphael Gottardo, Kelly G. Paulson, William J. Valente, Robert H. Pierce, Daniel Hunter, Anthony Rongvaux
Despite recent therapeutic progress, advanced melanoma remains lethal for many patients. The composition of the immune tumor microenvironment (TME) has decisive impacts on therapy response and disease outcome. High dimensional analyses of patient sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21525b08e8c3665f413dc3bf3fdb563b
https://doi.org/10.1101/2021.09.09.459682
https://doi.org/10.1101/2021.09.09.459682
Autor:
Jayasri G. Iyer, Robert H. Pierce, Raphael Gottardo, Paul Nghiem, Natalie Vandeven, Aric Colunga, Valentin Voillet, Cassian Yee, Daniel Hunter, Phil Greenberg, Samson J. Koelle, Felecia Wagener, Holly N. Thomas, William J. Valente, Candice D. Church, Jason H. Bielas, Kelly G. Paulson, Megan S. McAfee, Shailender Bhatia, M. Perdicchio, Rima M. Kulikauskas, Aude G. Chapuis, David M. Koelle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to improve outcomes; cellular immunotherapy trials offer a means to probe complex tumor–immune interfaces through defined T cell/antigen interactions. We treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89f08d5980d04456c2aecdd5cdcdebe
https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
Autor:
Jason stephany, John C. Rose, Jason J. Stephany, William J. Valente, Bridget M. Trevillian, Ha V. Dang, Jason H. Bielas, Dustin J. Maly, Douglas M. Fowler
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a22e73e2e97b51349f0ec2c021dd6a
https://doi.org/10.1038/protex.2017.066
https://doi.org/10.1038/protex.2017.066
Autor:
Jason H. Bielas, Bridget M. Trevillian, Jason J. Stephany, Ha V. Dang, John C. Rose, William J. Valente, Douglas M. Fowler, Dustin J. Maly
Publikováno v:
Nature methods
To investigate the kinetics of Cas9-mediated double strand break generation and repair in vivo, we developed two new tools. The first, chemically inducible Cas9 (ciCas9), is a rapidly-activated, single-component Cas9 variant engineered using a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c803b03043712cd6aaecf135d73c8b3c
https://pubmed.ncbi.nlm.nih.gov/28737741
https://pubmed.ncbi.nlm.nih.gov/28737741
Autor:
Rajiv Bharadwaj, Paul Wyatt, Joe Shuga, Donald A. Masquelier, Tarjei S. Mikkelsen, Mark T. Gregory, Junjie Zhu, Jerald P. Radich, Emily A. Stevens, Solongo B. Ziraldo, Christopher McFarland, Luz Montesclaros, Nolan G. Ericson, Alexander Wong, William J. Valente, Benjamin J. Hindson, Tobias Daniel Wheeler, Jason G. Underwood, H. Joachim Deeg, Jessica M. Terry, Kevin D. Ness, Phillip Belgrader, Stefanie Y. Nishimura, Geoffrey P. McDermott, Michael Schnall-Levin, Jason H. Bielas, Zachary Bent, Lan Beppu, Paul Ryvkin, Christopher Hindson, Grace X.Y. Zheng, Keith R. Loeb, Ryan Wilson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3′ mRNA counting of tens of thousands of single cells per sample. Cell encapsulation, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c253cde04091540cdaa92d1bfadff133
https://doi.org/10.1038/ncomms14049
https://doi.org/10.1038/ncomms14049
Autor:
Nolan G. Ericson, Jason H. Bielas, Paul D. White, Francesco Marchetti, William J. Valente, Alexandra S. Long
Publikováno v:
Nucleic Acids Research
The accumulation of somatic mitochondrial DNA (mtDNA) mutations contributes to the pathogenesis of human disease. Currently, mitochondrial mutations are largely considered results of inaccurate processing of its heavily damaged genome. However, mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ec3ebd19eb6fcf18ab26105700de47
https://pubmed.ncbi.nlm.nih.gov/27550180
https://pubmed.ncbi.nlm.nih.gov/27550180
Autor:
Nolan G. Ericson, Alexander Wong, Keith R. Loeb, Ryan Wilson, Zachary Bent, Emily A. Stevens, Tobias Daniel Wheeler, Rajiv Bharadwaj, H. Joachim Deeg, Jessica M. Terry, William J. Valente, Jason H. Bielas, Kevin D. Ness, Phillip Belgrader, Lan Beppu, Paul Ryvkin, Tarjei S. Mikkelsen, Geoffrey P. McDermott, Jerald P. Radich, Donald A. Masquelier, Solongo B. Ziraldo, Mark T. Gregory, Luz Montesclaros, Grace X.Y. Zheng, Christopher McFarland, Paul Wyatt, Christopher Hindson, Joe Shuga, Stefanie Y. Nishimura, Benjamin J. Hindson, Michael Schnall-Levin, Junjie Zhu
Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3′ mRNA counting of up to tens of thousands of single cells per sample. Cell encapsulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bb5ac0446559ec783467c8c0c59dd7
https://doi.org/10.1101/065912
https://doi.org/10.1101/065912
Autor:
Jason H. Bielas, William J. Valente
Publikováno v:
Mitochondria and Cell Death ISBN: 9781493936106
Recent studies have implicated mitochondrial DNA mutations in tumor progression. In this chapter, we provide a review of the studies reporting on mitochondrial DNA mutations and their possible contributions to carcinogenesis. We propose a revised, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::107f31ddb01e2effb833b48f7b94fc8f
https://doi.org/10.1007/978-1-4939-3612-0_7
https://doi.org/10.1007/978-1-4939-3612-0_7