Zobrazeno 1 - 10
of 220
pro vyhledávání: '"William A. Quinn"'
Autor:
Helena Costa-Verdera, Fanny Collaud, Christopher R. Riling, Pauline Sellier, Jayme M. L. Nordin, G. Michael Preston, Umut Cagin, Julien Fabregue, Simon Barral, Maryse Moya-Nilges, Jacomina Krijnse-Locker, Laetitia van Wittenberghe, Natalie Daniele, Bernard Gjata, Jeremie Cosette, Catalina Abad, Marcelo Simon-Sola, Severine Charles, Mathew Li, Marco Crosariol, Tom Antrilli, William J. Quinn, David A. Gross, Olivier Boyer, Xavier M. Anguela, Sean M. Armour, Pasqualina Colella, Giuseppe Ronzitti, Federico Mingozzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pompe disease is currently treated with enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase (GAA). Here, the authors show hepatic-directed gene therapy with AAV vectors enhances GAA bioavailability compared with ERT, result
Externí odkaz:
https://doaj.org/article/ecdd7a66d5fe4b0e825ff6e616f835cf
Autor:
William A. Quinn
Olde Clerkis Speche affirms both the historical legitimacy and the interpretive benefits of reading Troilus and Criseyde as if the text were initially composed for Chaucers own recital before a familiar audience. Proposing a qualification rather th
Autor:
Corinne J. Smith, Nikki Ross, Ali Kamal, Kevin Y. Kim, Elizabeth Kropf, Pascal Deschatelets, Cedric Francois, William J. Quinn, Inderpal Singh, Anna Majowicz, Federico Mingozzi, Klaudia Kuranda
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
AAV gene transfer is a promising treatment for many patients with life-threatening genetic diseases. However, host immune response to the vector poses a significant challenge for the durability and safety of AAV-mediated gene therapy. Here, we charac
Externí odkaz:
https://doaj.org/article/d9b0d374702f4585b36b080c36e4089e
Autor:
William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108500- (2020)
Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effe
Externí odkaz:
https://doaj.org/article/7bafd43031934dc89425250de8164ad0
Autor:
Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce V Lee, William J Quinn, Che-Pei Kung, Rexford Ahima, Joseph A Baur, Kathryn E Wellen, Qin Liu, Zachary T Schug, Donna L George, Maureen E Murphy
Publikováno v:
eLife, Vol 9 (2020)
The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased cancer risk in humans and mice. Due to impaired repression of the cystine importer Slc7a11, S47 cells show increased glutathione (GSH) accumulati
Externí odkaz:
https://doaj.org/article/c17ed4ebd0124f678260df2ab091b171
Autor:
Arielle Glatman Zaretsky, Christoph Konradt, Fabien Dépis, James B. Wing, Radhika Goenka, Daniela Gomez Atria, Jonathan S. Silver, Sunglim Cho, Amaya I. Wolf, William J. Quinn, Julie B. Engiles, Dorothy C. Brown, Daniel Beiting, Jan Erikson, David Allman, Michael P. Cancro, Shimon Sakaguchi, Li-Fan Lu, Christophe O. Benoist, Christopher A. Hunter
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1906-1916 (2017)
Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the factors that control PCs. We found that systemic infection alters the BM, greatly reducing PCs an
Externí odkaz:
https://doaj.org/article/76982e31a7d64e0c90b378be372684ec
Autor:
Emanuele Loro, Cholsoon Jang, William J. Quinn, Joseph A. Baur, Zoltan P. Arany, Tejvir S. Khurana
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise capacity and protects from diet-induced obesity by enhancing muscle energy metabolism, suggesting a role as exercise mimetic for IL15RA antagonists. Using control
Externí odkaz:
https://doaj.org/article/310e8f9e3742415c8bd3afe06681ae9c
Autor:
Dhanendra Tomar, Fabián Jaña, Zhiwei Dong, William J. Quinn, III, Pooja Jadiya, Sarah L. Breves, Cassidy C. Daw, Subramanya Srikantan, Santhanam Shanmughapriya, Neeharika Nemani, Edmund Carvalho, Aparna Tripathi, Alison M. Worth, Xueqian Zhang, Roshanak Razmpour, Ajay Seelam, Stephen Rhode, Anuj V. Mehta, Michael Murray, Daniel Slade, Servio H. Ramirez, Prashant Mishra, Glenn S. Gerhard, Jeffrey Caplan, Luke Norton, Kumar Sharma, Sudarsan Rajan, Darius Balciunas, Dayanjan S. Wijesinghe, Rexford S. Ahima, Joseph A. Baur, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3709-3725.e7 (2019)
Summary: Mitochondrial Ca2+ uniporter (MCU)-mediated Ca2+ uptake promotes the buildup of reducing equivalents that fuel oxidative phosphorylation for cellular metabolism. Although MCU modulates mitochondrial bioenergetics, its function in energy home
Externí odkaz:
https://doaj.org/article/77205bbeecaf4261b3e51221d39e06e1
Publikováno v:
Journal of Youth Development, Vol 16, Iss 5, Pp 231-250 (2021)
As the youth development field has grown, there has been an increased focus on building academic preparation programs in youth development that prepare leaders and staff in youth-serving organizations. Very few degree programs exist in preparing yout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6646b215eb687988ef3bd4d65fccb6d3
https://jyd.pitt.edu/ojs/jyd/article/view/1098
https://jyd.pitt.edu/ojs/jyd/article/view/1098