Výsledky vyhledávání - "William A. Paradise"

Nitric Oxide: Perspectives and Emerging Studies of a Well Known Cytotoxin

Autor: Benjamin J. Vesper, Ajay Goel, William A. Paradise, Kenneth W. Altman, G. Kenneth Haines, James A. Radosevich, Joshua D. Waltonen

Publikováno v: International Journal of Molecular Sciences, Vol 11, Iss 7, Pp 2715-2745 (2010)
International Journal of Molecular Sciences

The free radical nitric oxide (NO(*)) is known to play a dual role in human physiology and pathophysiology. At low levels, NO(*) can protect cells; however, at higher levels, NO(*) is a known cytotoxin, having been implicated in tumor angiogenesis an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d703fbe0c55032c6a9a263a95ab6ec
http://www.mdpi.com/1422-0067/11/7/2715/

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Photodynamic therapy: occupational hazards and preventative recommendations for clinical administration by healthcare providers

Autor: Benjamin J. Vesper, Steven E. Lacey, James A. Radosevich, William A. Paradise, John D. Breskey, Michael D. Colvard

Publikováno v: Photomedicine and laser surgery. 31(8)

Objective: Photodynamic therapy (PDT) as a medical treatment for cancers is an increasing practice in clinical settings, as new photosensitizing chemicals and light source technologies are developed and applied. PDT involves dosing patients with phot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3722157b90e5ad1f861f416d5b25a35
https://pubmed.ncbi.nlm.nih.gov/23859750

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Viruses and Head and Neck Cancer

Autor: James A. Radosevich, Dena J. Fischer, Joel B. Epstein, William A. Paradise

Publikováno v: Head & Neck Cancer: Current Perspectives, Advances, and Challenges ISBN: 9789400758261

This chapter presents an overview of the viruses thought to be associated with Head & Neck cancers. Human Papillomavirus is the most common and strongly linked virus associated with this cancer. Other viruses, such as Epstein – Barr virus (EBV) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1a69827a8277d499834fd10e976e51d
https://doi.org/10.1007/978-94-007-5827-8_13

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Part II. Mitochondrial mutational status of high nitric oxide adapted cell line BT-20 (BT-20-HNO) as it relates to human primary breast tumors

Autor: H. De Vitto, James A. Radosevich, E. A. Portari, Kim M. Elseth, Benjamin J. Vesper, B. S. Mendonça, Claudia Vitoria de Moura Gallo, William A. Paradise, Franklin David Rumjanek

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 34(1)

Mitochondria combine hydrogen and oxygen to produce heat and adenosine triphosphate (ATP). As a toxic by-product of oxidative phosphorylation (OXPHOS), mitochondria generate reactive oxygen species (ROS). These free radicals may cause damage to mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e21fcb33eb440cba36e5b35df9444b
https://pubmed.ncbi.nlm.nih.gov/23238816

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Part III. Molecular changes induced by high nitric oxide adaptation in human breast cancer cell line BT-20 (BT-20-HNO): a switch from aerobic to anaerobic metabolism

Autor: Jiaping Xue, B. S. Mendonça, William A. Paradise, Claudia Vitoria de Moura Gallo, Kim M. Elseth, Abdullah Onul, Benjamin J. Vesper, H. De Vitto, Franklin David Rumjanek, James A. Radosevich

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 34(1)

Nutrient deprivation and reactive oxygen species (ROS) play an important role in breast cancer mitochondrial adaptation. Adaptations to these conditions allow cells to survive in the stressful microenvironment of the tumor bed. This study is directed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6083b58f9a1b0967b5fc37b258c2a4d7
https://pubmed.ncbi.nlm.nih.gov/23238817

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Long-term adaptation of the human lung tumor cell line A549 to increasing concentrations of hydrogen peroxide

Autor: Abdullah Onul, James A. Radosevich, Gabor Tarjan, Humberto De Vitto, Kim M. Elseth, G. Kenneth Haines, Franklin David Rumjanek, William A. Paradise, Benjamin J. Vesper

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 33(3)

Previously, we demonstrated that A549, a human lung cancer cell line, could be adapted to the free radical nitric oxide (NO •). NO • is known to be over expressed in human tumors. The original cell line, A549 (parent), and the newly adapted A549-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdcb33971f700764adac94e4ec880e0
https://pubmed.ncbi.nlm.nih.gov/22407532

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Part I. Development of a model system for studying nitric oxide in tumors: high nitric oxide-adapted head and neck squamous cell carcinoma cell lines

Autor: Benjamin J. Vesper, Yaroslav R. Yarmolyuk, Gabor Tarjan, G. Kenneth Haines, Kim M. Elseth, James A. Radosevich, William A. Paradise

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 32(1)

The free radical nitric oxide (NO) is over-expressed in many tumors, including head and neck squamous cell carcinomas (HNSCC); however, the role NO plays in tumor pathophysiology is still not well understood. We, herein, report the development of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982dbcd54e6b9e892c5744cb32771a05
https://pubmed.ncbi.nlm.nih.gov/20972659

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