Výsledky vyhledávání - "William A. Muller"

Akademický článek

Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma

Autor: Lizhi Pang, Madeline Dunterman, Wenjing Xuan, Annette Gonzalez, Yiyun Lin, Wen-Hao Hsu, Fatima Khan, Robert S. Hagan, William A. Muller, Amy B. Heimberger, Peiwen Chen

Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112127- (2023)

Summary: Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects GBM hallmarks of immunosuppression and GSC maintenance in a par

Externí odkaz: https://doaj.org/article/221410c369144c329917d85e960e6be4

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Akademický článek

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer. Here, the authors show that ICAM1 is enriched in CTC clusters and its loss suppresse

Externí odkaz: https://doaj.org/article/017f7ea6455b4bbfa2e1554f4c8f4748

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Akademický článek

Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

Autor: Hideaki Nishihara, Sasha Soldati, Adrien Mossu, Maria Rosito, Henriette Rudolph, William A. Muller, Daniela Latorre, Federica Sallusto, Mireia Sospedra, Roland Martin, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten, Fabien Gosselet, Britta Engelhardt

Publikováno v: Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-18 (2020)

Abstract Background The brain barriers establish compartments in the central nervous system (CNS) that significantly differ in their communication with the peripheral immune system. In this function they strictly control T-cell entry into the CNS. T

Externí odkaz: https://doaj.org/article/9497e17519774cd08571d69620d5134f

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Akademický článek

Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium

Autor: Yang Mei, Gong Feng, Nina Rahimi, Baobing Zhao, Jingxin Zhang, Lan Cao, Jing Yang, Juehua Gao, Yihua Chen, Ronen Sumagin, William A. Muller, Ling Zhang, Peng Ji

Publikováno v: Blood Advances, Vol 1, Iss 20, Pp 1650-1656 (2017)

Abstract: Formin protein mDia1 is involved in actin polymerization and plays important roles in the migration and adhesion of hematopoietic cells. The mDia1 encoding gene is located on chromosome 5q, which is commonly deleted in patients with del(5q)

Externí odkaz: https://doaj.org/article/12d3f443cab84a73a66672a42b7c386a

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Akademický článek

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

Autor: Isabella Wimmer, Silvia Tietz, Hideaki Nishihara, Urban Deutsch, Federica Sallusto, Fabien Gosselet, Ruth Lyck, William A. Muller, Hans Lassmann, Britta Engelhardt

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is expr

Externí odkaz: https://doaj.org/article/a1c6c70ba4224e82ba5c12437904235e

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Akademický článek

Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses

Autor: Merideth Early, William G. Schroeder, Ranajana Unnithan, John M. Gilchrist, William A. Muller, Alan Schenkel

Publikováno v: PeerJ, Vol 5, p e3555 (2017)

Background 2′–4′ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine th

Externí odkaz: https://doaj.org/article/dbd04ac8550c408e924c2ec9f80e5ff0

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