Zobrazeno 1 - 10
of 73
pro vyhledávání: '"William A. McEwan"'
Autor:
Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J. Tuck, Sophie Keeling, Annabel E. Smith, Eric Hidari, Jeff Y.L. Lam, Melanie Burke, Sofia Lövestam, Rohan T. Ranasinghe, William A. McEwan, David Klenerman
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112725- (2023)
Summary: Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under pathological conditions, it becomes hyperphosphorylated and aggregates, a process that can be induced by treating cells with exogenously added tau fi
Externí odkaz:
https://doaj.org/article/0d8cb954a0e54cd6965759734192cc83
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract The deposition of tau aggregates throughout the brain is a pathological characteristic within a group of neurodegenerative diseases collectively termed tauopathies, which includes Alzheimer’s disease. While recent findings suggest the invo
Externí odkaz:
https://doaj.org/article/d540ac5e981d4160bd3639f7173fa3e4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The detection of pathogen-associated molecular patterns can elicit the production of type-I interferons (IFNs), soluble cytokines that induce a transcriptional state inhibitory to viral replication. Signatures of type-I IFN-driven gene expression, an
Externí odkaz:
https://doaj.org/article/658fa076c4464ad19ac75df07c6ba5a9
Autor:
Benjamin J. Tuck, Lauren V.C. Miller, Taxiarchis Katsinelos, Annabel E. Smith, Emma L. Wilson, Sophie Keeling, Shi Cheng, Marina J. Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C. James, William A. McEwan
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110776- (2022)
Summary: Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner. To accomplish this, tau must cross cell-limiting membranes, a process that is poorly understood. Here, we establish assays for the study of tau entry
Externí odkaz:
https://doaj.org/article/538c66f388cf44be883cb205f710e4fd
Autor:
Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract A fundamental property of infectious agents is their particulate nature: infectivity arises from independently-acting particles rather than as a result of collective action. Assemblies of the protein tau can exhibit seeding behaviour, potent
Externí odkaz:
https://doaj.org/article/8c71a3da926645f4b60a31a290b71149
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Ordered assemblies of proteins are found in the postmortem brains of sufferers of several neurodegenerative diseases. The cytoplasmic microtubule associated protein tau and alpha-synuclein (αS) are found in an assembled state in Alzheimer's disease
Externí odkaz:
https://doaj.org/article/ff251c40cf41409e994d34a76042b16d
Autor:
William A. McEwan
Publikováno v:
Antibodies, Vol 5, Iss 4, p 21 (2016)
TRIM21 has emerged as an atypical Fc receptor that is broadly conserved and widely expressed in the cytoplasm of mammalian cells. Viruses that traffic surface-bound antibodies into the cell during infection recruit TRIM21 via a high affinity interact
Externí odkaz:
https://doaj.org/article/d9f2cffc2a354e72b3ef1dbe97560936
Publikováno v:
Seminars in Cell & Developmental Biology. 126:138-149
Antibodies mediate the majority of their effects in the extracellular domain, or in intracellular compartments isolated from the cytosol. Under a growing list of circumstances, however, antibodies are found to gain access to the cytoplasm. Cytosolic
Autor:
Pablo Rodríguez-Silvestre, Marco Laub, Alexandra K. Davies, Julia P. Schessner, Patrycja A. Krawczyk, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik
During initiation of antiviral and antitumour T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on MHC class I. Cross-presentation relies on the unique ‘leakiness’ of endocytic compartments in DCs, whereby i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec99295124f93af5d707091d954a2d7
https://doi.org/10.1101/2023.01.31.525875
https://doi.org/10.1101/2023.01.31.525875
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports
The deposition of tau aggregates throughout the brain is a pathological characteristic within a group of neurodegenerative diseases collectively termed tauopathies, which includes Alzheimer’s disease. While recent findings suggest the involvement o