Zobrazeno 1 - 10
of 301
pro vyhledávání: '"William A. Lockwood"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background An increasing proportion of lung adenocarcinoma (LUAD) occurs in patients even after they have stopped smoking. Here, we aimed to determine whether tobacco smoking induced changes across LUADs from patients who formerly smoked cor
Externí odkaz:
https://doaj.org/article/d1cc08a9a5524077944370da23039055
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is relatively under characterized from an etiological and biological perspecti
Externí odkaz:
https://doaj.org/article/1f191c48fd2b4466984fa6064a235694
Autor:
Jennifer K. Luu, Fraser D. Johnson, Jana Jajarmi, Tianna Sihota, Rocky Shi, Daniel Lu, Dylan Farnsworth, Sandra E. Spencer, Gian Luca Negri, Gregg B. Morin, William W. Lockwood
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundLung cancer is the leading cause of cancer related death worldwide, mainly due to the late stage of disease at the time of diagnosis. Non-invasive biomarkers are needed to supplement existing screening methods to enable earlier detection an
Externí odkaz:
https://doaj.org/article/c0e77243976d436ea7b73fc2e00dc68e
Autor:
David E. Cohn, Aisling Forder, Erin A. Marshall, Emily A. Vucic, Greg L. Stewart, Kouther Noureddine, William W. Lockwood, Calum E. MacAulay, Martial Guillaud, Wan L. Lam
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The growth and metastasis of solid tumours is known to be facilitated by the tumour microenvironment (TME), which is composed of a highly diverse collection of cell types that interact and communicate with one another extensively. Many of these inter
Externí odkaz:
https://doaj.org/article/6eeb70efdf25415aa30135a285879a32
Autor:
Dylan A. Farnsworth, Yusuke Inoue, Fraser D. Johnson, Georgia de Rappard-Yuswack, Daniel Lu, Rocky Shi, Lok In Josephine Ma, Marissa S. Mattar, Romel Somwar, Marc Ladanyi, Arun M. Unni, William W. Lockwood
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract MEK inhibitors (MEKi) have limited efficacy in KRAS mutant lung adenocarcinoma (LUAD) patients, and this is attributed to both intrinsic and adaptive mechanisms of drug resistance. While many studies have focused on the former, there remains
Externí odkaz:
https://doaj.org/article/d1bc38b675aa48b9b89c98c59ec5707a
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102012- (2023)
Summary: Identification of effector targets is imperative to the characterization of the mechanisms of action of novel small molecules. Here, we describe steps to identify effector drug-protein interactions in lysates derived from cancer cell lines u
Externí odkaz:
https://doaj.org/article/b3a93d7084854adb91a91e6d7fd2a6bd
Publikováno v:
Oncogenesis, Vol 10, Iss 3, Pp 1-15 (2021)
Abstract Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention. Pharmacological inhibition of the bromodomain and extraterminal (BET) family of chromatin
Externí odkaz:
https://doaj.org/article/dd8d94dec3054315b2ba950064958702
Autor:
Huitao Liu, Yuan Chao Xue, Haoyu Deng, Yasir Mohamud, Chen Seng Ng, Axel Chu, Chinten James Lim, William W. Lockwood, William W.G. Jia, Honglin Luo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 207-218 (2020)
We recently discovered that coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS mutant lung adenocarcinoma. Nevertheless, the evident toxicity restricts the use of wild-type (WT)-CVB3 for cancer therapy. The current study aims to engine
Externí odkaz:
https://doaj.org/article/f7045a01818a4c3ba9b89afc259e27a9
Autor:
Fraser D. Johnson, John Ferrarone, Alvin Liu, Christina Brandstädter, Ravi Munuganti, Dylan A. Farnsworth, Daniel Lu, Jennifer Luu, Tianna Sihota, Sophie Jansen, Amy Nagelberg, Rocky Shi, Giovanni C. Forcina, Xu Zhang, Grace S.W. Cheng, Sandra E. Spencer Miko, Georgia de Rappard-Yuswack, Poul H. Sorensen, Scott J. Dixon, Udayan Guha, Katja Becker, Hakim Djaballah, Romel Somwar, Harold Varmus, Gregg B. Morin, William W. Lockwood
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110343- (2022)
Summary: Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here, we show that a compound termed LCS3, which s
Externí odkaz:
https://doaj.org/article/777c0ebba6e744a58fb41d6fac2350cb
Autor:
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith, William W. Lockwood
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Externí odkaz:
https://doaj.org/article/2c2a00203bef4e89885342925d64134f