Zobrazeno 1 - 10
of 508
pro vyhledávání: '"William A. Hawkins"'
Autor:
Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo, Ryan C. Fields
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, intratumoral T-cell infiltration correlates with improved overall survival (OS). Herein, we characterized the diversity
Externí odkaz:
https://doaj.org/article/020545a544174e6986a7dd89b240e669
Autor:
Rony Takchi, Bethany C. Prudner, Qingqing Gong, Takaomi Hagi, Kenneth F. Newcomer, Linda X. Jin, Suwanna Vangveravong, Brian A. Van Tine, William G. Hawkins, Dirk Spitzer
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As such, S2L were developed as imaging probes (ISO1) or as cancer therapeutics, alone (
Externí odkaz:
https://doaj.org/article/ab445ff44b324f118dd5b3e9afc0d657
Autor:
Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B. Dodhiawala, Lin Li, Yutong Geng, Chia-Kuei Mo, Jay Mahsl, Li Ding, Ramaswamy Govindan, Sherri Davies, Jacqueline Mudd, William G. Hawkins, Ryan C. Fields, David G. DeNardo, Deborah Knoerzer, Jason M. Held, Patrick M. Grierson, Andrea Wang-Gillam, Marianna B. Ruzinova, Kian-Huat Lim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Targeting the mitogen-activated protein kinase (MAPK) cascade in pancreatic ductal adenocarcinoma (PDAC) remains clinically unsuccessful. We aim to develop a MAPK inhibitor-based therapeutic combination with strong preclinical efficacy. Util
Externí odkaz:
https://doaj.org/article/fb6737dcacf54c9e884795a4aec86099
Autor:
Takaomi Hagi, Suwanna Vangveravong, Rony Takchi, Qingqing Gong, S. Peter Goedegebuure, Herve Tiriac, Brian A. Van Tine, Matthew A. Powell, William G. Hawkins, Dirk Spitzer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cancer selective apoptosis remains a therapeutic challenge and off-target toxicity has limited enthusiasm for this target clinically. Sigma-2 ligands (S2) have been shown to enhance the cancer selectivity of small molecule drug candidates by
Externí odkaz:
https://doaj.org/article/9e2904ef921e408c9a9dcba07e068c79
Autor:
Erik P. Storrs, Prathamesh Chati, Abul Usmani, Ian Sloan, Bradley A. Krasnick, Ramandeep Babbra, Peter K. Harris, Chloe M. Sachs, Faridi Qaium, Deyali Chatterjee, Chris Wetzel, S. Peter Goedegebuure, Thomas Hollander, Hephzibah Anthony, Jennifer Ponce, Ateeq M. Khaliq, Shahed Badiyan, Hyun Kim, David G. Denardo, Gabriel D. Lang, Natalie D. Cosgrove, Vladimir M. Kushnir, Dayna S. Early, Ashiq Masood, Kian-Huat Lim, William G. Hawkins, Li Ding, Ryan C. Fields, Koushik K. Das, Aadel A. Chaudhuri
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Numerous cell states are known to comprise the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, the developmental stemness and co-occurrence of these cell states remain poorly defined. Here, we performed single-
Externí odkaz:
https://doaj.org/article/903543a9685a4ed99c96f10cecf7b517
Autor:
Lauren K. Park, Kian-Huat Lim, Jonas Volkman, Mina Abdiannia, Hannah Johnston, Zack Nigogosyan, Marilyn J. Siegel, Janet B. McGill, Alexis M. McKee, Maamoun Salam, Rong M. Zhang, Da Ma, Karteek Popuri, Vincent Tze Yang Chow, Mirza Faisal Beg, William G. Hawkins, Linda R. Peterson, Joseph E. Ippolito
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Thus, there is an urgent need for safe and effective novel therapies. PDAC’s excessive reliance on glucose metabolism for its metabolic needs provides a target for
Externí odkaz:
https://doaj.org/article/fb0695e376a84b689b17957969847ae8
Autor:
Jorge G. Zarate Rodriguez, Heidy Cos, Rohit Srivastava, Alice Bewley, Lacey Raper, Dingwen Li, Ruixuan Dai, Gregory A. Williams, Ryan C. Fields, William G. Hawkins, Chenyang Lu, Dominic E. Sanford, Chet W. Hammill
Publikováno v:
Surgery in Practice and Science, Vol 15, Iss , Pp 100212- (2023)
Background: Higher levels of preoperative physical activity are associated with improved outcomes after pancreatectomy, but it remains unclear if preoperative activity levels are modifiable. Methods: Patients undergoing pancreatectomy were randomized
Externí odkaz:
https://doaj.org/article/fa7e20a024d94bb0b4cb3067fd7d5188
Autor:
Pratibha S. Binder, Yassar M. Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Suwanna Vangveravong, David G. Mutch, William G. Hawkins, Matthew A. Powell, Dirk Spitzer
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Ovarian cancer is initially responsive to frontline chemotherapy. Unfortunately, it often recurs and becomes resistant to available therapies and the survival rate for advanced and recurrent ovarian cancer is unacceptably low. We
Externí odkaz:
https://doaj.org/article/cb670c039a1d4d34b64cee5350257cc9
Autor:
Hui Peng, Lijin Li, Chong Zuo, Michael Y. Chen, Xiuli Zhang, Nancy B. Myers, Graham D. Hogg, David G. DeNardo, S. Peter Goedegebuure, William G. Hawkins, William E. Gillanders
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCancer neoantigens are important targets of cancer immunotherapy and neoantigen vaccines are currently in development in pancreatic ductal adenocarcinoma (PDAC) and other cancer types. Immune regulatory mechanisms in pancreatic cancer may l
Externí odkaz:
https://doaj.org/article/0e3fe50aa4d44130bd63e7763d67c6e4
Autor:
Usman Panni, Rohit Srivastava, Alice Bewley, Gregory A. Williams, Ryan C. Fields, Dominic E. Sanford, William G. Hawkins, Natasha Leigh, Chet W. Hammill
Publikováno v:
HPB. 25:659-666
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff23dc603681eaa7bdf8b767715f5f49
https://doi.org/10.1016/j.hpb.2023.02.015
https://doi.org/10.1016/j.hpb.2023.02.015