Zobrazeno 1 - 10
of 2 498
pro vyhledávání: '"William A. Hawkins"'
Publikováno v:
The American Mathematical Monthly, 2013 Apr 01. 120(4), 295-297.
Autor:
Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo, Ryan C. Fields
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, intratumoral T-cell infiltration correlates with improved overall survival (OS). Herein, we characterized the diversity
Externí odkaz:
https://doaj.org/article/020545a544174e6986a7dd89b240e669
Autor:
Marsden, Jean
Publikováno v:
The Oxford Companion to Shakespeare, 2 ed., 2015.
Externí odkaz:
http://www.oxfordreference.com/view/10.1093/acref/9780198708735.001.0001/acref-9780198708735-e-1316
Autor:
Rony Takchi, Bethany C. Prudner, Qingqing Gong, Takaomi Hagi, Kenneth F. Newcomer, Linda X. Jin, Suwanna Vangveravong, Brian A. Van Tine, William G. Hawkins, Dirk Spitzer
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As such, S2L were developed as imaging probes (ISO1) or as cancer therapeutics, alone (
Externí odkaz:
https://doaj.org/article/ab445ff44b324f118dd5b3e9afc0d657
Autor:
Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B. Dodhiawala, Lin Li, Yutong Geng, Chia-Kuei Mo, Jay Mahsl, Li Ding, Ramaswamy Govindan, Sherri Davies, Jacqueline Mudd, William G. Hawkins, Ryan C. Fields, David G. DeNardo, Deborah Knoerzer, Jason M. Held, Patrick M. Grierson, Andrea Wang-Gillam, Marianna B. Ruzinova, Kian-Huat Lim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Targeting the mitogen-activated protein kinase (MAPK) cascade in pancreatic ductal adenocarcinoma (PDAC) remains clinically unsuccessful. We aim to develop a MAPK inhibitor-based therapeutic combination with strong preclinical efficacy. Util
Externí odkaz:
https://doaj.org/article/fb6737dcacf54c9e884795a4aec86099
Autor:
Takaomi Hagi, Suwanna Vangveravong, Rony Takchi, Qingqing Gong, S. Peter Goedegebuure, Herve Tiriac, Brian A. Van Tine, Matthew A. Powell, William G. Hawkins, Dirk Spitzer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cancer selective apoptosis remains a therapeutic challenge and off-target toxicity has limited enthusiasm for this target clinically. Sigma-2 ligands (S2) have been shown to enhance the cancer selectivity of small molecule drug candidates by
Externí odkaz:
https://doaj.org/article/9e2904ef921e408c9a9dcba07e068c79
Autor:
Erik P. Storrs, Prathamesh Chati, Abul Usmani, Ian Sloan, Bradley A. Krasnick, Ramandeep Babbra, Peter K. Harris, Chloe M. Sachs, Faridi Qaium, Deyali Chatterjee, Chris Wetzel, S. Peter Goedegebuure, Thomas Hollander, Hephzibah Anthony, Jennifer Ponce, Ateeq M. Khaliq, Shahed Badiyan, Hyun Kim, David G. Denardo, Gabriel D. Lang, Natalie D. Cosgrove, Vladimir M. Kushnir, Dayna S. Early, Ashiq Masood, Kian-Huat Lim, William G. Hawkins, Li Ding, Ryan C. Fields, Koushik K. Das, Aadel A. Chaudhuri
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Numerous cell states are known to comprise the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, the developmental stemness and co-occurrence of these cell states remain poorly defined. Here, we performed single-
Externí odkaz:
https://doaj.org/article/903543a9685a4ed99c96f10cecf7b517
Autor:
Potter, Elisabeth Walton
Publikováno v:
Oregon Historical Quarterly, 2000 Oct 01. 101(3), 386-388.
Externí odkaz:
https://www.jstor.org/stable/20615077
Autor:
Marsden, Jean
Publikováno v:
The Oxford Companion to Shakespeare, 1 ed., 2003.
Externí odkaz:
https://www.oxfordreference.com/display/10.1093/acref/9780198117353.001.0001/acref-9780198117353-e-1316
Autor:
Lauren K. Park, Kian-Huat Lim, Jonas Volkman, Mina Abdiannia, Hannah Johnston, Zack Nigogosyan, Marilyn J. Siegel, Janet B. McGill, Alexis M. McKee, Maamoun Salam, Rong M. Zhang, Da Ma, Karteek Popuri, Vincent Tze Yang Chow, Mirza Faisal Beg, William G. Hawkins, Linda R. Peterson, Joseph E. Ippolito
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Thus, there is an urgent need for safe and effective novel therapies. PDAC’s excessive reliance on glucose metabolism for its metabolic needs provides a target for
Externí odkaz:
https://doaj.org/article/fb0695e376a84b689b17957969847ae8