Zobrazeno 1 - 10
of 172
pro vyhledávání: '"William A. Coetzee"'
Autor:
Bo Yang, Jia-Lu Yao, Jian-Yi Huo, Yu-Long Feng, William A. Coetzee, Guang-Yin Xu, Hua-Qian Yang
Publikováno v:
Channels, Vol 16, Iss 1, Pp 137-147 (2022)
ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection. However, the molecular mechanisms r
Externí odkaz:
https://doaj.org/article/eb887e513ba64cf0819a6926e4d62b9e
Autor:
Ivan Gando, Manuel Becerra Flores, I.-Shan Chen, Hua-Qian Yang, Tomoe Y. Nakamura, Timothy J. Cardozo, William A. Coetzee
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: KATP channels have diverse roles, including regulation of insulin secretion and blood flow, and protection against biological stress responses and are excellent therapeutic targets. Different subclasses of KATP channels exist in various t
Externí odkaz:
https://doaj.org/article/3e472d27d00c4839be30fd2fd463659c
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
Autor:
Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J. Alvarado, Igor Dolgalev, Thomas V. Karathanos, Kabir Malkani, Chantal J.M. Van Opbergen, Joanne J.A. van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E. Morley, William A. Coetzee, Natalia A. Trayanova, Michael J. Ackerman, Toon A.B. van Veen, Hector H. Valdivia, Mario Delmar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adul
Externí odkaz:
https://doaj.org/article/4417834a57fb40c18499881ece963bc6
Autor:
Jingyun Dong, Nori Williams, Marina Cerrone, Christopher Borck, Dawei Wang, Bo Zhou, Lucy S. Eng, Ekaterina Subbotina, Sung Yon Um, Ying Lin, Kevin Ruiter, Lisa Rojas, William A. Coetzee, Barbara A. Sampson, Yingying Tang
Publikováno v:
Heliyon, Vol 4, Iss 12, Pp e01015- (2018)
Background: Molecular testing of the deceased (Molecular Autopsy) is an overlooked area in the United States healthcare system and is not covered by medical insurance, leading to ineffective care for surviving families of thousands of sudden unexpect
Externí odkaz:
https://doaj.org/article/8e2b5976955749938fa58b1b462a2e9d
Autor:
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C1017-C1027
Sirtuins are NAD+-dependent deacetylases with beneficial roles in conditions relevant to human health, including metabolic disease, type II diabetes, obesity, cancer, aging, neurodegenerative diseases, and cardiac ischemia. Since ATP-sensitive K+ (KA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b8f5536727143b817a280c163e1f31
https://doi.org/10.1152/ajpcell.00459.2022
https://doi.org/10.1152/ajpcell.00459.2022
Autor:
Hua-Qian Yang, Marta Pérez-Hernández, Jose Sanchez-Alonso, Andriy Shevchuk, Julia Gorelik, Eli Rothenberg, Mario Delmar, William A Coetzee
Publikováno v:
eLife, Vol 9 (2020)
We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ank
Externí odkaz:
https://doaj.org/article/7e798350db304527a6da45b02859691b
Publikováno v:
Biophysical Journal. 122:523a-524a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f1489b1faeadcd11ff0e163b9e9d2e
https://doi.org/10.1016/j.bpj.2022.11.2782
https://doi.org/10.1016/j.bpj.2022.11.2782
Autor:
Hua-Qian Yang, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Natalie Samper, Timothy Cardozo, Mario Delmar, Show-Ling Shyng, William A. Coetzee
Publikováno v:
Am J Physiol Cell Physiol
Sarcolemmal/plasmalemmal ATP-sensitive K+ (KATP) channels have key roles in many cell types and tissues. Hundreds of studies have described how the KATP channel activity and ATP sensitivity can be regulated by changes in the cellular metabolic state,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011749ed2fbef18c0573653ae17c6815
https://europepmc.org/articles/PMC9169827/
https://europepmc.org/articles/PMC9169827/
Autor:
Ivan Gando, Manuel Becerra-Flores, I-Shan Chen, Hua-Qian Yang, Show-Ling Shyng, Tomoe Y. Nakamura, Timothy J. Cardozo, William A. Coetzee
Publikováno v:
Biophysical Journal. 122:257a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7d8bf7ef138e703c4a193b0a76187c
https://doi.org/10.1016/j.bpj.2022.11.1482
https://doi.org/10.1016/j.bpj.2022.11.1482
Publikováno v:
Forensic Science International. 293:37-46
The TRPM4 gene encodes the subunit of the CaWe have identified thirteen uncommon missense VUS in TRPM4 by testing 95 targeted genes implicated in channelopathy and cardiomyopathy in 330 cases of SUD. In several cases there were co-existing VUS in one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d60aae6fd49a84f70a7c93ca428600
https://doi.org/10.1016/j.forsciint.2018.10.006
https://doi.org/10.1016/j.forsciint.2018.10.006