Zobrazeno 1 - 10 of 411 pro vyhledávání: '"William A. Bonner"'
1
Akademický článek
Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
Autor: Urbain Weyemi, Bindu D. Paul, Adele M. Snowman, Parthav Jailwala, Andre Nussenzweig, William M. Bonner, Solomon H. Snyder
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.
Externí odkaz: https://doaj.org/article/253374c82ccd40c5a5caef64387f25f3
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2
Akademický článek
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
Autor: Kévin Contrepois, Clément Coudereau, Bérénice A. Benayoun, Nadine Schuler, Pierre-François Roux, Oliver Bischof, Régis Courbeyrette, Cyril Carvalho, Jean-Yves Thuret, Zhihai Ma, Céline Derbois, Marie-Claire Nevers, Hervé Volland, Christophe E. Redon, William M. Bonner, Jean-François Deleuze, Clotilde Wiel, David Bernard, Michael P. Snyder, Claudia E. Rübe, Robert Olaso, François Fenaille, Carl Mann
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.
Externí odkaz: https://doaj.org/article/d72fdc8a41414edbbb502f55ed36f498
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8
Akademický článek
The histone variant H2A.X is a regulator of the epithelial–mesenchymal transition
Autor: Urbain Weyemi, Christophe E. Redon, Rohini Choudhuri, Towqir Aziz, Daisuke Maeda, Myriem Boufraqech, Palak R. Parekh, Taresh K. Sethi, Manjula Kasoji, Natalie Abrams, Anand Merchant, Vinodh N. Rajapakse, William M. Bonner
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The histone H2A variants are involved in DNA repair, gene regulation and cancer development. In this study, the authors unravel an additional role for H2A.X in the regulation of mesenchymal-like traits and activation of the EMT transcription factors,
Externí odkaz: https://doaj.org/article/3167703fb83c4199980e307269ce14a0
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9
Akademický článek
Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.
Autor: Jiuping Ji, Yiping Zhang, Christophe E Redon, William C Reinhold, Alice P Chen, Laura K Fogli, Susan L Holbeck, Ralph E Parchment, Melinda Hollingshead, Joseph E Tomaszewski, Quentin Dudon, Yves Pommier, James H Doroshow, William M Bonner
Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171582 (2017)
Phosphorylated H2AX (γ-H2AX) is a sensitive marker for DNA double-strand breaks (DSBs), but the variability of H2AX expression in different cell and tissue types makes it difficult to interpret the meaning of the γ-H2AX level. Furthermore, the assa
Externí odkaz: https://doaj.org/article/c5271db0c4334b48803bddf775b6a904
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10
Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis
Autor: Bindu D. Paul, Urbain Weyemi, Adarsha P. Malla, Maged M. Harraz, Deeya Bhattacharya, William M. Bonner, Solomon H. Snyder, Myriem Boufraqech
Publikováno v: Proceedings of the National Academy of Sciences. 116:7471-7476
Phosphorylation of histone H2AX is a major contributor to efficient DNA repair. We recently reported neurobehavioral deficits in mice lacking H2AX. Here we establish that this neural failure stems from impairment of mitochondrial function and repress
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab640f81a23f242d07cd8d4012989f7
https://doi.org/10.1073/pnas.1820245116
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