Výsledky vyhledávání - "William A. Bolhofer"

Structure-activity, theoretical, and x-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists

Autor: John J. Baldwin, Brian T. Phillips, W C Lumma, Robb Cm, William A. Bolhofer, John B. Bicking, Torchiana Ml, Jacob M. Hoffman, H. B. Schlegel, Graham M. Smith

Publikováno v: Journal of Medicinal Chemistry. 27:1047-1052

The furan ring of the histamine H2 receptor antagonist 3-amino-4-[[2-[[[5-[(dimethylamino)methyl]-2-furanyl]-methyl] thio]ethyl]amino]-1,2,5-thiadiazole 1-oxide (1a) was replaced by thiophene, pyridine, benzene, and pyrrole. The relative receptor aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d0137b7083c38809d80c12d0e9ba4e
https://doi.org/10.1021/jm00374a019

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2-Mercaptoacetamidines as gastric antisecretory agents

Autor: Adolph M. Pietruszkiewicz, William A. Bolhofer, C. N. Habecker, Henry I. Jacoby, M. L. Torchiana, Clement A. Stone

Publikováno v: Journal of Medicinal Chemistry. 22:295-301

A series of N-substituted 2-mercaptoacetamidines was synthesized and evaluated for gastric antisecretory activity in dogs stimulated with gastrin tetrapeptide. The most potent analogues showed 80--95% inhibition of acid secretion after an oral dose o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab794c23208d884fdd9d6ae8ceb2069f
https://doi.org/10.1021/jm00189a015

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Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogs related to cimetidine and tiotidine

Autor: Charles N. Habecker, Adolph M. Pietruszkiewicz, Baldwin John J, William A. Bolhofer, Edward J. Cragoe, Brian T. Phillips, William C. Lumma, Jacob M. Hoffman, M. L. Torchiana

Publikováno v: Journal of Medicinal Chemistry. 26:140-144

Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H2 receptors. The flexible methylthioethyl connecting chain was replaced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43aef62d68b6ea27490250f8d4fbbc8
https://doi.org/10.1021/jm00356a005

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Further Calculations of Sea Level Air Trajectories over the Equatorial Indian Ocean

Autor: William C. Bolhofer, Henry M. E. Van De Boogaard, Gandikota V. Rao

Publikováno v: Monthly Weather Review. 106:1465-1475

Quasi-horizontal 48 h air trajectories were constructed over the equatorial Indian Ocean utilizing a mean sea level pressure map for July and a series of daily pressure maps in June 1970. The purposes of this calculation were 1) to determine whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f185ef195a4c6b71dae05ad7aab10ad
https://doi.org/10.1175/1520-0493(1978)106<1465:fcosla>2.0.co

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