Zobrazeno 1 - 10
of 56
pro vyhledávání: '"William A, Sather"'
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 321-334 (2017)
Summary: Potentiation of synaptic strength relies on postsynaptic Ca2+ signals, modification of dendritic spine structure, and changes in gene expression. One Ca2+ signaling pathway supporting these processes routes through L-type Ca2+ channels (LTCC
Externí odkaz:
https://doaj.org/article/96f0152f32fc42d2830f557d040799ba
Autor:
Angela R. Wild, Brooke L. Sinnen, Philip J. Dittmer, Matthew J. Kennedy, William A. Sather, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3537-3550.e4 (2019)
Summary: Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range s
Externí odkaz:
https://doaj.org/article/6ce51fc0392c409f9aedb860a58b1965
Autor:
Jonathan G. Murphy, Jennifer L. Sanderson, Jessica A. Gorski, John D. Scott, William A. Catterall, William A. Sather, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1577-1588 (2014)
L-type voltage-gated Ca2+ channels (LTCC) couple neuronal excitation to gene transcription. LTCC activity is elevated by the cyclic AMP (cAMP)-dependent protein kinase (PKA) and depressed by the Ca2+-dependent phosphatase calcineurin (CaN), and both
Externí odkaz:
https://doaj.org/article/b423bdfc8fac42d9851f3358a9fc2e92
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1410-1416 (2014)
Within neurons, Ca2+-dependent inactivation (CDI) of voltage-gated L-type Ca2+ channels shapes cytoplasmic Ca2+ signals. CDI is initiated by Ca2+ binding to channel-associated calmodulin and subsequent Ca2+/calmodulin activation of the Ca2+-dependent
Externí odkaz:
https://doaj.org/article/d26b4a4f73354477ac3f6f601d47566c
Autor:
Mark L. Dell'Acqua, Jonathan G. Murphy, William A. Sather, Kevin C. Crosby, Philip J. Dittmer
Publikováno v:
Molecular Biology of the Cell. 30:1743-1756
In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca2+influx through voltage-gated L-type calcium channels (LTCC) and NFAT translocation to the nucleus following its dephosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fe94fa58c4becb763045fcc8267720a
https://doi.org/10.1091/mbc.e19-01-0060
https://doi.org/10.1091/mbc.e19-01-0060
Publikováno v:
Proceedings of the National Academy of Sciences. 116:13611-13620
Patterns of postsynaptic activity that induce long-term potentiation of fast excitatory transmission at glutamatergic synapses between hippocampal neurons cause enlargement of the dendritic spine and promote growth in spine endoplasmic reticulum (ER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05e24b34c989b87a9c360b53b256a46c
https://doi.org/10.1073/pnas.1902461116
https://doi.org/10.1073/pnas.1902461116
Publikováno v:
Neural Plasticity, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/39b04002c1d64c78a5d717b4b1ef32ca
Publikováno v:
Neural Plasticity, Vol 2013 (2013)
Over the last twenty years of research on cellular mechanisms of pain hypersensitivity, long-term potentiation (LTP) of synaptic transmission in the spinal cord dorsal horn (DH) has emerged as an important contributor to pain pathology. Mechanisms th
Externí odkaz:
https://doaj.org/article/bb671053c7734f70afa98b4d0b1ba4ce
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(27)
Patterns of postsynaptic activity that induce long-term potentiation of fast excitatory transmission at glutamatergic synapses between hippocampal neurons cause enlargement of the dendritic spine and promote growth in spine endoplasmic reticulum (ER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18202659aaebb5cde30499f345107c18
https://pubmed.ncbi.nlm.nih.gov/31209051
https://pubmed.ncbi.nlm.nih.gov/31209051
Autor:
Jonathan G, Murphy, Kevin C, Crosby, Philip J, Dittmer, William A, Sather, Mark L, Dell'Acqua
Publikováno v:
Molecular Biology of the Cell
In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca2+ influx through voltage-gated L-type calcium channels (LTCC) and NFAT translocation to the nucleus following its dephosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b039a8341de544403f0d33d3b046832
https://pubmed.ncbi.nlm.nih.gov/31091162
https://pubmed.ncbi.nlm.nih.gov/31091162