Zobrazeno 1 - 10 of 95 pro vyhledávání: '"William A, Laframboise"'
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Akademický článek
Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males
Autor: Mariam Saad, Sandra J. Lee, Aik Choon Tan, Issam M. El Naqa, F. Stephen Hodi, Lisa H. Butterfield, William A. LaFramboise, Walter Storkus, Arivarasan D. Karunamurthy, Jose Conejo-Garcia, Patrick Hwu, Howard Streicher, Vernon K. Sondak, John M. Kirkwood, Ahmad A. Tarhini
Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background We hypothesized that a gender difference in clinical response may exist to adjuvant CTLA4 blockade with ipilimumab versus high-dose IFNα (HDI). We investigated differences in candidate immune biomarkers in the circulation and tum
Externí odkaz: https://doaj.org/article/97294a01bb964fb78b177d7c556dded1
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5
Akademický článek
Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer
Autor: Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Publikováno v: EBioMedicine, Vol 67, Iss , Pp 103347- (2021)
Background: A non-synonymous single nucleotide polymorphism of the ATG16L1 gene, T300A, is a major Crohn's disease (CD) susceptibility allele, and is known to be associated with increased apoptosis induction in the small intestinal crypt base in CD s
Externí odkaz: https://doaj.org/article/c5e63bed203f4d959a6a62c8a7adc23a
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6
Akademický článek
Identification of a candidate stem cell in human gallbladder
Autor: Rohan Manohar, Yaming Li, Helene Fohrer, Lynda Guzik, Donna Beer Stolz, Uma R. Chandran, William A. LaFramboise, Eric Lagasse
Publikováno v: Stem Cell Research, Vol 14, Iss 3, Pp 258-269 (2015)
There are currently no reports of identification of stem cells in human gallbladder. The differences between human gallbladder and intrahepatic bile duct (IHBD) cells have also not been explored. The goals of this study were to evaluate if human feta
Externí odkaz: https://doaj.org/article/c9d324a862c349b29f699e007a7aa768
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7
A Tumor and Immune-Related Micro-RNA Signature Predicts Relapse-Free Survival of Melanoma Patients Treated with Ipilimumab
Autor: Iyad Kobeissi, Islam Eljilany, Tala Achkar, William A. LaFramboise, Lucas Santana-Santos, Ahmad A. Tarhini
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8167
Despite the unprecedented advances in the treatment of melanoma with immunotherapy, there continues to be a major need for biomarkers of clinical benefits and immune resistance associated with immune checkpoint inhibitors; microRNA could play a vital
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad62ce23227b63ea485307794aef51f0
https://doi.org/10.3390/ijms24098167
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8
Abstract 5704: An integrated immune signature predictive of adjuvant immunotherapeutic benefits for high-risk melanoma
Autor: Alyssa N. Obermayer, Timothy I. Shaw, Sandra J. Lee, F. Stephen Hodi, William A. LaFramboise, Walter Storkus, Arivarasan D. Karunamurthy, Patrick Hwu, Howard Streicher, Dung-Tsa Chen, John M. Kirkwood, Ahmad A. Tarhini
Publikováno v: Cancer Research. 83:5704-5704
Introduction CTLA4 blockade with ipilimumab was more favorable than interferon-α2b (IFN) in high-risk melanoma in phase adjuvant III trial E1609. Characterization of the pretreatment tumor immune biomarkers and clinical covariates may inform the lik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b390e35eb9ddf29200ab0c57b2d7baaa
https://doi.org/10.1158/1538-7445.am2023-5704
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9
Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary
Autor: Ahmad A Tarhini, Sandra J Lee, Aik-Choon Tan, Issam M El Naqa, F Stephen Hodi, Lisa H Butterfield, William A LaFramboise, Walter J Storkus, Arivarasan D Karunamurthy, Jose R Conejo-Garcia, Patrick Hwu, Howard Streicher, Vernon K Sondak, John M Kirkwood
Publikováno v: Journal for immunotherapy of cancer, vol 10, iss 1
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
BackgroundMelanoma of unknown primary (MUP) represents a poorly understood group of patients both clinically and immunologically. We investigated differences in prognosis and candidate immune biomarkers in patients with unknown compared with those wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6594a7e70e14c1deed6cba96d4698ce
https://escholarship.org/uc/item/4dh8b1ng
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10
Absolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms
Autor: José Luis Capelo, Rajiv Dhir, Hugo M. Santos, Susana Jorge, Dimitrios Korentzelos, Swati Satturwar, William A. LaFramboise, Gabriela Quiroga-Garza, Carlos Lodeiro, Jacek R. Wiśniewski, Sheldon I. Bastacky
Publikováno v: BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
BMC Medicine
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Background Renal neoplasms encompass a variety of malignant and benign tumors, including many with shared characteristics. The diagnosis of these renal neoplasms remains challenging with currently available tools. In this work, we demonstrate the tot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eac2e7c78cb82a745b57ca0776ba53
https://hdl.handle.net/10362/125105
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