Zobrazeno 1 - 10
of 60
pro vyhledávání: '"William P. Esler"'
Autor:
Aarti Sawant‐Basak, Arthur J. Bergman, Jessica Mancuso, Sakambari Tripathy, James R. Gosset, Laure Mendes da Costa, William P. Esler, Roberto A. Calle
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Co‐administration of clesacostat (acetyl‐CoA carboxylase inhibitor, PF‐05221304) and ervogastat (diacylglycerol O‐acyltransferase inhibitor, PF‐06865571) in laboratory models improved non‐alcoholic fatty liver disease (NAFLD)/non
Externí odkaz:
https://doaj.org/article/ea4079a3b1344ca986312423c445ad90
Autor:
Trenton T. Ross, Collin Crowley, Kenneth L. Kelly, Anthony Rinaldi, David A. Beebe, Matthew P. Lech, Robert V. Martinez, Santos Carvajal-Gonzalez, Magalie Boucher, Dinesh Hirenallur-Shanthappa, Jeffrey Morin, Alan C. Opsahl, Sarah R. Vargas, Kendra K. Bence, Jeffrey A. Pfefferkorn, William P. Esler
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 829-851 (2020)
Background & Aims: Disordered metabolism, steatosis, hepatic inflammation, and fibrosis contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase (ACC) catalyzes the first committed step in de novo lipogenesis (DNL
Externí odkaz:
https://doaj.org/article/beb0f489c5c840ed83b968a320f69c68
Autor:
Nereida Jiménez de Oya, William P. Esler, Kim Huard, Ayman F. El-Kattan, Georgios Karamanlidis, Ana-Belén Blázquez, Priscila Ramos-Ibeas, Estela Escribano-Romero, Andrés Louloudes-Lázaro, Josefina Casas, Francisco Sobrino, Kyle Hoehn, David E. James, Alfonso Gutiérrez-Adán, Juan-Carlos Saiz, Miguel A. Martín-Acebes
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 624-636 (2019)
ABSTRACTFlaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infe
Externí odkaz:
https://doaj.org/article/d350776893df432399bdb06605ae985f
Autor:
William P. Esler, Kendra K. Bence
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 2, Pp 247-267 (2019)
The prevalence and diagnosis of nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide and currently has no FDA-approved pharmacotherapy. The increase in disease burden of NAFLD and a more severe form of this progressive liver disease, non
Externí odkaz:
https://doaj.org/article/7292ae36583c4ea4810f92a2218ea318
Autor:
Jemy A. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing, Gabriele Sonnenberg, Kou Kou, Matt Blatnik, Richard Allen, Yan Weng, Nicholas B. Vera, Kristin Chidsey, Arthur Bergman, Veena Somayaji, Collin Crowley, Michelle F. Clasquin, Anu Nigam, Melissa A. Fulham, Derek M. Erion, Trenton T. Ross, William P. Esler, Thomas V. Magee, Jeffrey A. Pfefferkorn, Kendra K. Bence, Morris J. Birnbaum, Gregory J. Tesz
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101196- (2021)
Objective: Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-
Externí odkaz:
https://doaj.org/article/83d51c2650cb4492a69b4c32dbb702cc
Autor:
Aditi R. Saxena, Stephanie‐An Lyle, Kaivan Khavandi, Ruolun Qiu, Mark Whitlock, William P. Esler, Albert M. Kim
Publikováno v:
Diabetes, Obesity and Metabolism. 25:992-1001
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::573fe791dc67dff06094efb2e8eb4af4
https://doi.org/10.1111/dom.14946
https://doi.org/10.1111/dom.14946
Autor:
Albert M. Kim, Neeta B. Amin, Arthur Bergman, Roberto A. Calle, Theresa Tuthill, Kou Kou, Sudeepta Aggarwal, Naresh Aggarwal, Collin Crowley, Anthony Rinaldi, Santos Carvajal-Gonzalez, Veena Somayaji, Kendra K. Bence, Jessica Mancuso, Trenton T. Ross, Magalie Boucher, William P. Esler, Robert Dullea, Jeffrey A. Pfefferkorn, Małgorzata Inglot, Greg Tesz
Publikováno v:
Nature Medicine. 27:1836-1848
Alterations in lipid metabolism might contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, no pharmacological agents are currently approved in the United States or the European Union for the treatment of NAFLD. Two pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6895fcce96fd1d7f12fcd3678e85c1ff
https://doi.org/10.1038/s41591-021-01489-1
https://doi.org/10.1038/s41591-021-01489-1
Autor:
Aditi R, Saxena, Stephanie-An, Lyle, Kaivan, Khavandi, Ruolun, Qiu, Mark, Whitlock, William P, Esler, Albert M, Kim
Publikováno v:
Diabetes, obesitymetabolism.
To assess the safety, tolerability, and pharmacodynamics (PD) of ketohexokinase inhibitor PF-06835919 in participants with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM).This double-blind, placebo-controlled, parallel-gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aef06f1c8c4636838f4176ff9ab780c5
https://pubmed.ncbi.nlm.nih.gov/36515213
https://pubmed.ncbi.nlm.nih.gov/36515213
Autor:
Jessica E C Jones, William P Esler, Rushi Patel, Adhiraj Lanba, Nicholas B Vera, Jeffrey A Pfefferkorn, Cecile Vernochet
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169566 (2017)
Tumor cell proliferation and migration processes are regulated by multiple metabolic pathways including glycolysis and de novo lipogenesis. Since acetyl-CoA carboxylase (ACC) is at the junction of lipids synthesis and oxidative metabolic pathways, we
Externí odkaz:
https://doaj.org/article/a869620da9a442ed9fe7c835033fb4e2
Autor:
William S. Nowland, Steven W. Kumpf, Trenton T. Ross, Christopher J. Bowman, Gregg D. Cappon, Donald S Stedman, Scott D Davenport, William P. Esler, Christine Stethem, Natasha R. Catlin, Elise M. Lewis, Sarah N. Campion
Publikováno v:
Toxicological Sciences. 179:183-194
Acetyl-CoA carboxylase (ACC) is an enzyme within the de novo lipogenesis (DNL) pathway and plays a role in regulating lipid metabolism. Pharmacologic ACC inhibition has been an area of interest for multiple potential indications including oncology, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6d9eb6a77626c055c46264ceba500b
https://doi.org/10.1093/toxsci/kfaa169
https://doi.org/10.1093/toxsci/kfaa169