Zobrazeno 1 - 10
of 87
pro vyhledávání: '"William F. Huffman"'
Autor:
Octerloney B. McDonald, Carla A. Donatelli, William F. Huffman, Toshihiro Hamajima, Christine Thompson, Kelly E. Fisher, Martha A. Sarpong, Jamin C Wang, David Sutton, Dashyant Dhanak, Peter J. Tummino, Jun Tang, Ken A. Newlander, Zhihong V Lai, Hong Xiang, Kosuke Sasaki, Domingos J. Silva, Mary Ann Hardwicke, Jerry L. Adams, Cynthia A. Parrish, Schmidt Stanley J, Denis R. Patrick, Hiroko Nakamura, Jingsong Yang, Catherine A. Oleykowski, Robert A. Copeland, Amita M. Chaudhari, Ramona Plant, David H. Drewry, Kristin K Koretke-Brown, Nicholas D. Adams, Joelle Lorraine Burgess
Publikováno v:
Journal of Medicinal Chemistry. 53:3973-4001
The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may provide a new therapy for the treatment of tumors with Aurora kinase amplification. Herein we
Autor:
Vernal R. Vaden, Janice A. Vasko, Lago Amparo M, John Fox, Sanjay Kumar, William F. Huffman, Maggie Schultz, Hyking Haley, James F. Callahan, Xiaoguang Liang, Bingming Yi, Theodore M. Danoff, Lorraine A. Fitzpatrick, M. Gowen, George B. Stroup, Nemeth Edward F, Christopher Matheny, Sandra J. Hoffman, Eric G. Delmar, Robert W. Marquis, Pradip K. Bhatnagar
Publikováno v:
Bone. 46:534-542
Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precu
Autor:
Dulcie B. Schmidt, William F. Huffman, Jeanne McDONALD, F L Stassen, Heidemarie Greene, James S. Stefankiewicz, L Sulat, Michael L. Moore, Daryl Ashton-Shue, Grace Heckman, L. B. Kinter
Publikováno v:
International Journal of Peptide and Protein Research. 28:379-385
Vasopressin antagonist analogs having alanine or glycine at position 7 were essentially equipotent with analogs with proline, N-methylalanine or sarcosine at position 7. This demonstrates that the conformational constraint imposed by an N-alkyl resid
Autor:
William F. Huffman, Ken A. Newlander, Amita M. Chaudhari, Shu-Yun Zhang, Michael L. Moore, Jeffrey T. Finer, Kevin J. Duffy, Antony N. Shaw, Melody Diamond, David Sutton, Robert A. Copeland, Michael N. Zimmerman, Chiu-Mei M Sung, Leo F. Faucette, Roman Sakowicz, Jeffrey R. Jackson, Lusong Luo, Kurt R. Auger, Kenneth W. Wood, Jeffrey D. Carson, Carla A. Donatelli, Cynthia A. Parrish, Erin D. Hugger, Steven D. Knight, Lance Ridgers, Nicholas D. Adams, Joelle Lorraine Burgess, Dashyant Dhanak
Publikováno v:
Journal of Medicinal Chemistry. 50:4939-4952
Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to curre
Autor:
Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat
Autor:
William H. Miller, Catherine C.K. Yuan, Kalindi Vaidya, Brian J. Polizzi, Dennis T. Takata, Rebecca Claire Greenwood, Dirk A. Heerding, Mark A. Seefeld, Scott B. Winram, Valerie Berry, Martha S. Head, Walter J. Burgess, Andrew P. Fosberry, Nicola G. Wallis, David J. Payne, Stephen Rittenhouse, William F. Huffman, Paul M. Keller, Kevin L. Salyers, Manley Peter J, Kenneth A. Newlander, Deborah Dee Jaworski, Courtney Slater-Radosti, Cheryl A. Janson, Walter E. DeWolf, Irene N. Uzinskas, John Brosky, Stewart C. Pearson, Xiayang Qiu, Emile Chen, Terrance D. Moore, Martin G. Smyth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3118-3124
Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening
Autor:
William F. Huffman, Paul M. Keller, Valerie Berry, Walter E. DeWolf, William H. Miller, Catherine C.K. Yuan, Mark A. Seefeld, Stephen Rittenhouse, Brian J. Polizzi, Stewart C. Pearson, Cheryl A. Janson, Dirk A. Heerding, Walter J. Burgess, Martha S. Head, Terrance D. Moore, Kenneth A. Newlander, Xiayang Qiu, Irene N. Uzinskas, David J. Payne
Publikováno v:
Journal of Medicinal Chemistry. 45:3246-3256
Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our eff...
Autor:
Kenneth A. Newlander, Kalindi Vaidya, William F. Huffman, William H. Miller, Paul M. Keller, Walter E. DeWolf, Terrance D. Moore, Xiayang Qiu, Courtney Slater-Radosti, Cheryl A. Janson, Mark A. Seefeld, Martin G. Smyth, David J. Payne, Deborah Dee Jaworski, Andrew P. Fosberry, Walter J. Burgess, Stephen Rittenhouse
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2241-2244
An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI).
Autor:
Dirk A. Heerding, Walter E. DeWolf, Stephen Rittenhouse, William H. Miller, Kalindi Vaidya, Catherine C.K. Yuan, Xiayang Qiu, Dennis T. Takata, Courtney Slater-Radosti, Cheryl A. Janson, Ward W. Smith, Andrew P. Fosberry, Terrance D. Moore, Edward McManus, William F. Huffman, Deborah Dee Jaworski, David J. Payne, George M. Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2061-2065
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
Publikováno v:
Tetrahedron Letters. 41:6997-7000
An efficient solid-phase parallel synthesis of aryloxypropanolamines is described. Mitsunobu coupling was used to attach ( R )-(+)- and ( S )-(−)-glycidol to resin-bound phenols, then the epoxide ring was opened with amines. A 25-member array was s