Zobrazeno 1 - 6
of 6
pro vyhledávání: '"William Craigo"'
Autor:
Zhili Sun, Deidre A. MacKenna, Bheemarao G Ugarkar, K. Raja Reddy, William Craigo, Serge H. Boyer, Mark D. Erion, Jorge E. Gomez-Galeno, Hongjian Jiang, Julie Esterbrook
Publikováno v:
Journal of Medicinal Chemistry. 49:7711-7720
Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissue
Autor:
William Craigo, Thanh H Nguyen, Matthew P. Grote, Qun Dang, Mingwei Chen, Deidre A. MacKenna, Edward Earl Cable, Scott J. Hecker, Zhili Sun, Paul A. Rolzin, Mark D. Erion, Serge H. Boyer, Jorge Gomez-Galeno, Paul D. van Poelje, Patricia D. Finn, David L. Linemeyer, Bert Chi
AMP-activated protein kinase (AMPK) is a heterotrimeric kinase that regulates cellular energy metabolism by affecting energy-consuming pathways such as de novo lipid biosynthesis and glucose production as well as energy-producing pathways such as lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74327482476a1458c7fc78c85a45a39a
https://europepmc.org/articles/PMC4007905/
https://europepmc.org/articles/PMC4007905/
Autor:
Jay DaRe, Serge H. Boyer, Timothy J. Colby, Paul D. van Poelje, Mark D. Erion, Kristin Ollis, William Craigo, Zhili Sun, Michael C Matelich, Jorge E. Gomez-Galeno, James M. Fujitaki, K. Raja Reddy, Bheemarao G Ugarkar
Publikováno v:
Journal of medicinal chemistry. 51(3)
Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodrugs were synthesized with
Autor:
Edward B. Skibo, Robert H. Lemus, Rogelio Martinez, Robert T. Dorr, Xiaofen Huang, William Craigo
Publikováno v:
Journal of medicinal chemistry. 45(25)
A series of pyrimidoquinazoline analogues, possessing either 4,5-g or 5,4-g fusion, were studied with respect to cytotoxicity, topoisomerase II inhibitory activity, in vivo activity, and DNA cleavage and DNA−protein cross-linking properties. These
Publikováno v:
Journal of medicinal chemistry. 42(17)
The pyrrolo[1,2-a]benzimidazole (PBI) reductive alkylating agents have been investigated in this laboratory since their discovery in the late 1980s. Of all the structural modifications of the PBIs investigated so far, the variation of the 3-substitue
Autor:
K. Raja Reddy, Michael C. Matelich, Bheemarao G. Ugarkar, Jorge E. Gómez-Galeno, Jay DaRe, Kristin Ollis, Zhili Sun, William Craigo, Timothy J. Colby, James M. Fujitaki, Serge H. Boyer, Paul D. van Poelje, Mark D. Erion
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p666-676, 11p