Zobrazeno 1 - 10
of 184
pro vyhledávání: '"William A. Beard"'
Autor:
Joonas A. Jamsen, Akira Sassa, Lalith Perera, David D. Shock, William A. Beard, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.
Externí odkaz:
https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synth
Externí odkaz:
https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd1
Publikováno v:
ACS Omega, Vol 5, Iss 25, Pp 15317-15324 (2020)
Externí odkaz:
https://doaj.org/article/0d610d077b2c4704b25c867d569d6658
Autor:
Joonas A. Jamsen, William A. Beard, Lars C. Pedersen, David D. Shock, Andrea F. Moon, Juno M. Krahn, Katarzyna Bebenek, Thomas A. Kunkel, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bou
Externí odkaz:
https://doaj.org/article/982a48bce8204f249e81938b26845c43
Autor:
David D. Shock, Samuel H. Wilson, Lalith Perera, Joonas A. Jamsen, William A. Beard, Akira Sassa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Reactive oxygen species (ROS) oxidize cellular nucleotide pools and cause double strand breaks (DSBs). Non-homologous end-joining (NHEJ) attaches broken chromosomal ends together in mammalian cells. Ribonucleotide insertion by DNA polymerase (pol) μ
Autor:
Ming-Lang Zhao, Donna F. Stefanick, Cristina A. Nadalutti, William A. Beard, Samuel H. Wilson, Julie K. Horton
Publikováno v:
DNA Repair. 126:103486
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 25, Pp 15317-15324 (2020)
ACS Omega, Vol 5, Iss 25, Pp 15317-15324 (2020)
DNA replication and repair reactions involve the addition of a deoxynucleoside monophosphate onto a growing DNA strand with the loss of pyrophosphate. This chemical reaction is also reversible; the addition of pyrophosphate generates a deoxynucleosid
Autor:
M.R. Smith, William A. Beard, David D. Shock, Bret D. Freudenthal, Samuel H. Wilson, Marc M. Greenberg
Publikováno v:
Nucleic Acids Research
4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Oxidized dGTP (8-oxo-7,8-dihydro-2´-deoxyguanosine triphosphate, 8-oxodGTP) insertion by DNA polymerases strongly promotes cancer and human disease. How DNA polymerases discriminate against oxidized and undamaged nucleotides, especially in error-pro
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72131 (2013)
To aid in the characterization of the relationship of structure and function for human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT), this investigation utilized DNAs containing benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-modi
Externí odkaz:
https://doaj.org/article/5227c6e64cd94b928d9dbbc7d6c18241