GABAa receptor density alterations revealed in a mouse model of early moderate prenatal ethanol exposure using [18F]AH114726

Autor: Van T. Nguyen, Nyoman D. Kurniawan, Gary Cowin, Graham J. Galloway, William Trigg, Karine Mardon, Quang M. Tieng, Rajiv Bhalla, Suyinn Chong, Xin Song, Damion H.R. Stimson, Alexander Jackson

Publikováno v: Nuclear Medicine and Biology. :44-51

Introduction Prenatal ethanol exposure (PEE) has been shown to alter the level and function of receptors in the brain, one of which is GABAa receptors (GABAaR), the major inhibitory ligand gated ion channels that mediate neuronal inhibition. High dos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b68caaee17a22f548943687678320985
https://doi.org/10.1016/j.nucmedbio.2020.07.005

Radiosynthesis of ( R , S )‐[ 18 F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971

Autor: Franklin I. Aigbirhio, David J. Williamson, Xiouyun Zhou, Michael Kassiou, Eryn L. Werry, Luxi Qiao, Emily Fisher, Saijinder Luthra, Nisha Kuzhuppilly-Ramakrishnan, William Trigg, Matthew Hird, Selena Milicevic Sephton, Lindsay McMurray

Publikováno v: ChemMedChem. 14:982-993

This work was supported by Medical Research Council (UK) grant awards RG46503 (LM, MH, XZ) and RG70550 (EF), National Institute of Health Research (UK), Cambridge Biomedical Research Unit in Dementia (EF, NKR) and the Herchel Smith Fellowship program

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d10da184470c7142fee35bf39694c109
https://doi.org/10.1002/cmdc.201900023

Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice

Autor: Maren K. Schroeder, Bin Liu, Robert G. Hinshaw, Mi-Ae Park, Shuyan Wang, Shipra Dubey, Grace Geyu Liu, Qiaoqiao Shi, Peter Holton, Vladimir Reiser, Paul A. Jones, William Trigg, Marcelo F. Di Carli, Barbara J. Caldarone, Jacqueline P. Williams, M. Kerry O’Banion, Cynthia A. Lemere

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13305
International Journal of Molecular Sciences, Vol 22, Iss 13305, p 13305 (2021)

Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab402b86fe8447cefd0c0b86a1a56a0a
https://doi.org/10.3390/ijms222413305

Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer’s-like transgenic mice

Autor: Lee A. Trojanczyk, M. Kerry O'Banion, Qiaoqiao Shi, Paul A. Jones, Shuyan Wang, Bin Liu, Marcelo F. Di Carli, Robert G. Hinshaw, Paul Lorello, Jacqueline P. Williams, Jeffrey L. Frost, Vladimir Reiser, Kevin X. Le, Mi-Ae Park, William Trigg, Anthony P. Belanger, Cynthia A. Lemere, Shipra Dubey, Barbara J. Caldarone, Peter Holton

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)

Space travel will expose people to high-energy, heavy particle radiation, and the cognitive deficits induced by this exposure are not well understood. To investigate the short-term effects of space radiation, we irradiated 4-month-old Alzheimer’s d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e9573b5fbcc079fa620107f5dc963
https://doi.org/10.1038/s41598-019-48615-1

Comment on ' In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates'

Autor: Jonathan P. Coles, Matthias J. Koepp, Colm J. McGinnity, Ella Hirani, Erik Årstad, Nisha Singh, Marian Galovic, Paul A. Jones, William Trigg, Alexander Hammers, David J. Brooks, Feng Luo, Rainer Hinz, Daniela A. Riaño Barros, Oliver D. Howes, Katherine Beck, John S. Duncan

Publikováno v: McGinnity, C J, Årstad, E, Beck, K, Brooks, D J, Coles, J P, Duncan, J S, Galovic, M, Hinz, R, Hirani, E, Howes, O D, Jones, P A, Koepp, M J, Luo, F, Riaño Barros, D A, Singh, N, Trigg, W & Hammers, A 2019, ' Comment on " In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates" ', ACS Chemical Neuroscience, vol. 10, no. 1, pp. 768-772 . https://doi.org/10.1021/acschemneuro.8b00246
Mcginnity, C J, Årstad, E, Beck, K, Brooks, D J, Coles, J P, Duncan, J S, Galovic, M, Hinz, R, Hirani, E, Howes, O D, Jones, P A, Koepp, M J, Luo, F, Riaño Barros, D A, Singh, N, Trigg, W & Hammers, A 2018, ' Comment on “In Vivo [18 F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates” ', ACS Chemical Neuroscience . https://doi.org/10.1021/acschemneuro.8b00246

Schoenberger and colleagues ( Schoenberger et al. ( 2018 ) ACS Chem. Neurosci. 9 , 298 - 305 ) recently reported attempts to demonstrate specific binding of the positron emission tomography (PET) radiotracer, [18F]GE-179, to NMDA receptors in both ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06b1e1aac50fe573519e9ab0bc649a4
https://pure.au.dk/portal/da/publications/comment-on--in-vivo-18fge179-brain-signal-does-not-show-nmdaspecific-modulation-with-drug-challenges-in-rodents-and-nonhuman-primates(b7023bd9-48c1-4ddf-b729-28d1245b194c).html