Zobrazeno 1 - 10
of 27
pro vyhledávání: '"William, Riordan"'
Publikováno v:
Cells, Vol 13, Iss 19, p 1644 (2024)
Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology and medicine. One key mechanism involves the acetylation and deacetylation of lysine residues on histone core proteins and other critical p
Externí odkaz:
https://doaj.org/article/71f3e07a51a84f9aa36cecf4037838d1
Autor:
Eric J. Silverman, William Riordan
Publikováno v:
The Palgrave Handbook of Popular Culture as Philosophy ISBN: 9783319971346
The Palgrave Handbook of Popular Culture as Philosophy
The Palgrave Handbook of Popular Culture as Philosophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea860cb9089526f7984e7dacbb25fea5
https://doi.org/10.1007/978-3-319-97134-6_90-1
https://doi.org/10.1007/978-3-319-97134-6_90-1
Publikováno v:
Separation Science and Technology. 45:1-10
Separation of viruses and other contaminants from protein therapeutics using anion exchange membrane adsorbers is a successful new approach to viral clearance; however, the fundamental phenomena that control performance are not well understood. For e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d21e6509fa457a79343cb320231bc8
https://doi.org/10.1080/01496390903401770
https://doi.org/10.1080/01496390903401770
Autor:
John A. Blessing, Carol Aghajanian, Gary C. Reid, Stephen C. Rubin, Koen DeGeest, Jacob Rotmensch, Robert S. Mannel, Kathleen M. Darcy, Russell J. Schilder, William Riordan
Publikováno v:
Gynecologic Oncology. 115:215-220
Objective To determine the activity and pharmacodynamics (PD) of bortezomib in platinum-sensitive epithelial ovarian or primary peritoneal cancer (EOC/PPC). Patients and methods Eligible women with recurrent EOC/PPC progressing between 6 and 12 month
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7ce850d4f67006d30ba7dabb897c64
https://doi.org/10.1016/j.ygyno.2009.07.023
https://doi.org/10.1016/j.ygyno.2009.07.023
Autor:
Mark R. Etzel, William Riordan
Publikováno v:
Journal of Chromatography A. 1216:2621-2624
Clearance of biological impurities is an essential part of the manufacture of biotechnology-derived products such as monoclonal antibodies (mAbs). Salt is required during manufacture to solubilize the mAb product and stabilize it against aggregation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e385cea4741765639173a229860eaa
https://doi.org/10.1016/j.chroma.2008.09.101
https://doi.org/10.1016/j.chroma.2008.09.101
Autor:
Merrill J. Egorin, Gurkamal Chatta, Lisa L. von Moltke, Suresh Ramalingam, Michael D. Karol, William Riordan, Rachel Neuwirth, Michael R Cooper, Ramesh K. Ramanathan, William L. Trepicchio, Michael Rader, Eric X. Chen, Karthik Venkatakrishnan
Publikováno v:
Clinical Therapeutics. 31:2444-2458
Background: The proteasome inhibitor bortezomib undergoes oxidative biotransformation via multiple cytochrome P450 (CYP) enzymes, with CYP3A4 identified as a partial, yet potentially important, contributor based on in vitro drug metabolism studies. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e7f3cce84d94a9cedd638354e7eaab
https://doi.org/10.1016/j.clinthera.2009.11.012
https://doi.org/10.1016/j.clinthera.2009.11.012
Autor:
William Riordan, Robert Z. Orlowski, Jason M. Collins, Anastasia Ivanova, Celeste Lindley, E. Claire Dees, Dixie Lee Esseltine, Frances A. Collichio, Lisa A. Carey, Bert H. O'Neil
Publikováno v:
Cancer Chemotherapy and Pharmacology. 63:99-107
Pre-clinical studies combining the proteasome inhibitor bortezomib with anthracyclines have shown enhanced anti-tumor activity. We conducted a phase I trial of bortezomib and pegylated liposomal doxorubicin (PLD) in patients with refractory solid tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8c7f1a8847115f803de5c9f5b2ff84
https://doi.org/10.1007/s00280-008-0716-8
https://doi.org/10.1007/s00280-008-0716-8
Autor:
Michael Chopp, Li Zhang, Nancy E. Stagliano, Xianshuang Liu, Mei Lu, Zheng Gang Zhang, William Riordan, Ann Hozeska
Publikováno v:
Thrombosis and Haemostasis. 95:166-173
SummaryStroke elicits a progressive vascular dysfunction, which contributes to the evolution of brain injury. Thrombolysis with tissue plasminogen activator (tPA) promotes adverse vascular events that limit the therapeutic window of stroke to three h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35060e568d96ceaba20122246d0837b3
https://doi.org/10.1160/th05-07-0477
https://doi.org/10.1160/th05-07-0477
Autor:
A. Keith Stewart, Donna E. Reece, Ann Mohrbacher, Gurkamal Chatta, Michael D. Karol, Lisa L. von Moltke, Chaim Shustik, William Riordan, Milin Acharya, Rachel Neuwirth, Howard A. Burris, Karthik Venkatakrishnan, Peter Zannikos, Sagar Lonial, Daniel M. Sullivan
Characterize bortezomib pharmacokinetics/pharmacodynamics in relapsed myeloma patients after single and repeat intravenous administration at two doses.Forty-two patients were randomized to receive bortezomib 1.0 or 1.3 mg/m(2), days 1, 4, 8, 11, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025d63a7ec9ba31d77d9d2dbc703833b
https://europepmc.org/articles/PMC3951913/
https://europepmc.org/articles/PMC3951913/
Autor:
Steven M C O Minnesot Heilmann, Mark R. Etzel, Kurt Brorson, William Riordan, Kannan Seshadri
Publikováno v:
Biotechnology progress. 25(6)
Clearance of impurities such as viruses, host cell protein (HCP), and DNA is a critical purification design consideration for manufacture of monoclonal antibody therapeutics. Anion exchange chromatography has frequently been utilized to accomplish th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ea9a578ff7a9a6f7a6dd8d4ab12eba
https://pubmed.ncbi.nlm.nih.gov/19728393
https://pubmed.ncbi.nlm.nih.gov/19728393